Current Regime Research Articles

What does religion have to do with it: Exploring noninstitutional arguments for effective enforcement of IPR

AbstractThrough this paper the authors intend to establish a connect between religion and Intellectual Property Rights (IPR) particularly how various religions have justified IPRs and analyze whether religion can prove to be the much‐needed enforcement tool to fight infringement of IPRs. Intellectual Property is a domain which is governed purely by creativity and technology and has traditionally been justified by utilitarianism. However, the evidence we are in possession of does not entirely justify the rationale of exclusive rights granted under the current IPR regime. While questioning the contradictory evidence seems as a logical move, instead scholars are turning to nonindustrial faith‐based arguments which justify intellectual property as a moral end in itself. A growing number of academics are choosing to devote at least a portion of their research to examining how religious thought can influence approaches to difficult intellectual property questions because they find the religious texts to be a rich source of inspiration on both temporal and eternal issues. A major obstacle in the enforcement of IPR is that people are not entirely convinced that infringing IPR is unethical. This enforcement challenge, surprisingly in the presence of legislations, may be tackled by informal institutions such as religious commitments.

Demystifying the Black Box: A Technical Analysis of Transparency Requirements in Clinical AI Systems

This analysis examines the adequacy of Ghana's current regulatory framework in addressing AI explainability in clinical decision support systems. It evaluates existing healthcare laws, derives underlying principles, and assesses their application to AI governance. The study finds significant gaps in the current regulatory regime, including a lack of AI-specific provisions, insufficient explainability requirements, and inadequate frameworks for liability and accountability. While existing principles provide a foundation, they are insufficient to fully address the challenges posed by AI in healthcare. The analysis concludes that comprehensive regulatory development is needed, including AI-specific healthcare regulations, technical standards for explainability, and enhanced regulatory capacity. This study is significant as it provides a roadmap for developing effective AI explainability regulations in Ghana's healthcare sector. It highlights the urgent need for regulatory evolution to ensure safe, ethical, and transparent use of AI in clinical decision support, potentially serving as a model for other developing nations facing similar challenges.

A tutela provisória de indisponibilidade de bens no regime da lei de improbidade administrativa

This study aims to analyze the constitutionality of the current regime of provisional protection of unavailability of assets, sanctioned in the Brazilian legal system by Law n. 14,230/2021. The methodology used in the investigation was descriptive-exploratory, with emphasis on the analysis of the legal arguments built over the last 20 years by doctrine and jurisprudence. Firstly, the contours of administrative impropriety in the national order and the jurisprudential, doctrinal and legal aspects related to the precautionary measure of unavailability of assets in actions of improbity were presented. Next, the essential characteristics of precautionary measures within the scope of Civil and Criminal Procedure were discussed, which contributed to the analysis of the constitutionality of the current regime of provisional protection of unavailability of assets. Finally, in the last topic, an analysis was made of the constitutionality of the new regime of provisional protection of unavailability of assets in actions of administrative improbity, concluding that the new legal device, which demands the presence of the double requirement of precautionary measures (fumus boni iuris and periculum in mora), is the one that best conforms to the legal principles in force in the Brazilian normative system.

Settling for a “good enough” school: contradictions of middle class reproduction in a small town in illiberal Hungary

Abstract The politics of the Orbán regime, in power in Hungary since 2010, are reshaping the possibilities for middle class reproduction and social mobility, as revealed through our analysis of parental dilemmas around school choice and future aspirations in a peripheral small town. As the main targets of re-industrialization and an important voter base for the regime, small towns are particularly relevant localities for studying the transformations of middle-class reproduction. Globally, anxieties over class reproduction pushes parents to invest more intensely in their children’s education, whereas increasingly worrying about the detrimental effects of related pressures on their child’s well-being. In small towns in the global semi-periphery, parental dilemmas around schooling appear in a particularly acute form due to the limited possibilities for social advancement, the high financial and emotional costs that mobility requires, and the racialised dimension of localised class relations. We contend that policies of the Orbán regime, such as the ‘churchification’ of education and the privileging of technical middle schools, have further reshaped local possibilities and routes of advancement. The tension between the pervasive promise of middle-class advancement through education and the locally rooted assessment of realistic employment possibilities exposes the contradictions of the current regime and helps to grasp the localised consequences of its socio-economic re-engineering. As in the studied context class is strongly racialised, we examine the strategies and dilemmas of middle class parents of the ethnic majority, and Roma parents who aspire to become middle class in a relational way, revealing how ethnicity further complicates middle class reproduction in Hungarian peripheral small towns.

Understanding the clinical and environmental drivers of antifungal resistance in the One Health context.

Antifungal drugs have had a tremendous impact on human health and the yields of crops. However, in recent years, due to usage both in a health setting and in agriculture, there has been a rapid emergence of antifungal drug resistance that has outpaced novel compound discovery. It is now globally recognized that new strategies to tackle fungal infection are urgently needed, with such approaches requiring the cooperation of both sectors and the development of robust antifungal stewardship rationales. In this review, we examine the current antifungal regimes in clinical and agricultural settings, focusing on two pathogens of importance, Candida auris and Aspergillus fumigatus, examining their drivers of antifungal resistance, the impact of dual-use azoles and the impact agricultural practices have on driving the emergence of resistance. Finally, we postulate that a One Health approach could offer a viable alternative to prolonging the efficacy of current antifungal agents.

Emerging Issues of IPR in Developing and Under Developed Countries

Intellectual Property Rights (IPR) are pivotal in driving innovation, creativity and economic growth globally. However, they also pose significant challenges, particularly for developing and underdeveloped nations. IPR can hinder access to essential goods, such as medications, educational materials, and agricultural technologies, exacerbating inequalities and stifling innovation. The monopolistic control of IPR by developed countries often leads to economic dependency and limits knowledge sharing crucial for addressing global challenges like climate change and public health. To mitigate these issues, a multifaceted approach is required, including strengthening legal framework, empowering communities, promoting technology transfer, and fostering international cooperation. Reforming the current IPR regime to ensure equitable access and benefit-sharing can harness the potential of intellectual property for sustainable development and global prosperity.

Inferring sediment-discharge event types in an Alpine catchment from sub-daily time series

Abstract. Fluvial sediment dynamics in mountain rivers are changing rapidly in a degrading cryosphere, raising the potential for erosive rainfall and runoff and detrimental effects on downstream areas. Hence, we need to understand better what characterises and drives episodic pulses of water and suspended solids in rivers. Here, we infer different types of such sediment-discharge events from 959 automatically detected events based on 16 metrics derived from 15 min time series of streamflow and suspended sediment concentrations from Vent–Rofental in the high Ötztal Alps, Austria. We use principal component analysis to extract uncorrelated event characteristics and cluster event types with a Gaussian mixture model. We interpret the thus inferred event types with catchment metrics describing antecedent conditions, hydrometeorological forcing, and fraction of catchment area with freezing temperatures and snow cover. We find event magnitude, hysteresis, and event shape complexity to be the main factors characterising the overall event regime. The most important characteristics distinguishing the event types are suspended sediment and streamflow magnitude and complexity of the hydro- and sedigraphs. Sediment-discharge hysteresis is less relevant for discerning event types. We derive four event types that we attribute to (1) compound rainfall–melt extremes, (2) glacier and seasonal snowmelt, (3) freeze–thaw-modulated snowmelt and precipitation events, and (4) late-season glacier melt. Glacier and snowmelt events driven by warm conditions and high insolation were the most frequent and contributed some 40 % to annual suspended sediment yield on average; compound rainfall–melt extremes were the rarest but contributed the second-highest proportion (26 %). Our approach represents a reproducible method for objectively estimating the variety of event-scale suspended sediment transport conditions in mountain rivers, which can provide insights into the contribution of different drivers to annual sediment yields in current and future regimes. Our findings highlight the importance of both meltwater and rainfall–runoff as drivers of high-magnitude suspended sediment fluxes in mountain rivers.

Public Perception of the Higher Education System under the Regime of the Islamic Emirate of Afghanistan

A modern, free, and dynamic higher education system is the basic and critical element of successful nation, and it can contribute to the progress and development of a country. Under both regimes of the Islamic Emirates of Afghanistan, the higher education system has undergone significant changes to align with the government’s interpretation of Islamic principles. This study is important to understand how Afghan society views the changes and policies implemented in the education sector under the current regime. The research study aims to evaluate public sentiment regarding access, quality, and inclusivity of higher education, particularly in relation to gender, curriculum changes, and ideological shifts. This paper focuses on the Taliban’s higher education system and investigates public responses to educational policies. This paper will offer recommendations to all stakeholders involved in the Afghan higher education system, aimed at improving its management and development during this crucial period. This work employs non-doctrinal and library research methodology. Non-doctrinal research examines how laws are applied and experienced in practice by collecting data through surveys, interviews, field studies, and observations. In this research study, data was collected through a questionnaire and then analyzed through SPSS. Moreover, in the library research methodology, most of the reputable and trustworthy academic sources such as textbooks, scholarly published and unpublished journal articles, law reports, and online websites related to the research area were analyzed through descriptive, explanatory, and analytical research approaches. The Afghan higher education system, established in the 1930s, has faced continuous political pressures, especially during periods of conflict like the Soviet invasion and civil war from the 1980s to 1990s. Women face major limitations in higher education, including restrictions on fields of study and exclusion from faculty positions, raising concerns about gender equality and access to education.

Regime support in Singapore: from enigma to ‘new normal’

ABSTRACT Singapore is seen as an outlier or abnormal case by political scientists, defying predictions in the social science literature about the causal connection between economic development and democratization. Using data from three different waves of the Asian Barometer Survey (ABS), we found that Singapore’s regime resilience is a product of citizen support for the government’s performance in providing economic welfare, together with positive evaluations of the current regime. But our findings also indicate that the degree to which these factors influence regime resilience has changed over time. What we found suggest that Singapore’s regime resilience cannot be simply reduced to elite repression, or an electorate that has chosen to trade freedom for economic development. The consistent electoral support received by the ruling party in Singapore is the product of a more complex relationship with democracy than just a vote for authoritarianism or prioritizing economic development over democracy.

Criminal enforcement of copyright in India

AbstractThe Supreme Court of India, in the recent case of Knit Pro International v. State of NCT of Delhi, clarified that the offence under S. 63 of the Copyright Act, 1957 is cognizable and nonbailable. This decision is likely to have far‐reaching consequences in the field of copyright enforcement. This article is meant to examine the current state of criminal enforcement of Copyright in India, its interface with freedom of speech and expression and the likely impact of the said judgement on copyright enforcement in India. The article starts with an overview of criminal remedies under the Copyright Act, 1957 and the criminal procedure applicable to those remedies. It then analyses the provisions in light of five factors which are considered crucial in criminalizing an offence—seriousness, proportionality, legal soundness, enforceability and alternative remedies. The article concludes that the current regime for criminal enforcement of copyright leans heavily in favour of enforcers and requires a change to ensure a balance between copyright and the right to freedom of speech and expression.

EU's “three-in-seven” road haulage cabotage rule – Impact imbalances across member states and the geography

Road cabotage within the EU, as a share of domestic transport of goods, varies greatly across member states. This can partly be attributed to EU's regime for consecutive cabotage. In addition to economic factors that reflect incomplete market integration, spatial factors appear to affect the impact of the current regime. The impact seems stronger for geographically large and centrally located countries with interregional homogeneity in trade. This may reflect that foreign hauliers under such conditions can utilize the characteristics of their standardized long-range trucks better, or because the likelihood of successfully fixing three favourable long-distance cabotage assignments within the seven days limit increases. Potential amendments to regulations in order to equalize the impact of EU's consecutive cabotage regime across member states' spatial characteristics include removing the limits to the number of trips within the seven days' time frame or shortening the time frame for carrying out the current maximum of three trips.

Uwarunkowania i dotychczasowe skutki inwazji Rosji na Ukrainę – (nie)bezpieczeństwo ontologiczne, przetrwanie reżimu czy dewiacja ideologiczna?

The article explains the reasons for the Russian offensive against Ukraine in terms of national security and Putin’s regime’s fear of democratization. It also offers a reflection upon ideological foundations prevalent in the Russian society. Such an approach will facilitate the understanding of how, in light of the core values and characteristics of that society, Ukraine has been portrayed as both a threat for Russian identity and an existential threat for Russia itself. The Russian invasion of Ukraine was undoubtedly aimed at gaining support at home and strengthening Putin’s regime. However, war is also integral to Putin’s project of Russia. Putin’s imperial thrust is rooted in the internal dynamics of this system. The current Russian regime is not so much based on ideology as it is striving to turn its propaganda clichés into an ideological platform. On the other hand, the war is accelerating the process of change in Russia – the current situation could lead to the collapse of Putin’s regime and even the disintegration of the Russian Federation itself, which harkens back to the collapse of the USSR.

A Review of the Oceanography and Antarctic Bottom Water Formation Offshore Cape Darnley, East Antarctica

AbstractAntarctic Bottom Water (AABW) is the densest water mass in the world and drives the lower limb of the global thermohaline circulation. AABW is formed in only four regions around Antarctica and Cape Darnley, East Antarctica, is the most recently discovered formation region. Here, we compile 40 years of oceanographic data for this region to provide the climatological oceanographic conditions, and review the water mass properties and their role in AABW formation. We split the region into three sectors (East, Central and West) and identify the main water masses, current regimes and their influence on the formation of Cape Darnley Bottom Water (CDBW). In the eastern sector, Prydz Bay, the formation of Ice Shelf Water preconditions the water (cold and fresh) that flows into the central sector to E, enhancing sea ice production in Cape Darnley Polynya. This produces a high salinity variant of Dense Shelf Water (DSW) (up to 35.15 g/kg) that we coin Burton Basin DSW. In contrast, the western sector of the Cape Darnley Polynya produces a low salinity variant (up to 34.85 g/kg) we coin Nielsen Basin DSW. The resultant combined CDBW is the warmest (upper temperature bound of 0.05C) AABW formed around Antarctica with an upper bound salinity of 34.845 g/kg. Our findings will contribute to planning future observing systems at Cape Darnley, determining the role that CDBW plays in our global oceanic and climate systems, and modeling past and future climate scenarios.

Biopolymer immune implants co-loaded with TMZ, R848 and IOX1 for perioperative therapy of glioblastoma

Glioblastoma (GBM), a prevalent and aggressive brain tumor, poses significant treatment challenges due to its rapid progression and the difficulty in achieving complete surgical resection. The current treatment regime, primarily surgery followed by radiotherapy and chemotherapy, offers limited success, with a five-year survival rate of less than 10 %. For addressing the challenges faced in the treatment of GBM, an approach using a biopolymer implant constructed with dynamic reversible covalent bonds, was designed to achieve controlled and constant-rate release of chemotherapy drug (Temozolomide, TMZ), immune adjuvant (Resiquimod, R848) and checkpoint inhibitor (5-carboxy-8-hydroxyquinoline, IOX1). The safety evaluation demonstrated the biocompatibility of the implants, with no significant inflammatory response or adverse effects on various systemic organs. In vivo antitumor study showed that the local delivery of drug combination via this implant significantly inhibited tumor recurrence of orthotopic GBM. Immune analysis revealed that the combination of the three drugs effectively activated systemic antitumor immune responses and induced memory effects. The synergistic mechanism of the drug combination was further validated by RNA whole sequencing. The innovative approach of combining chemotherapy and immunotherapy in biopolymer immune implants for GBM treatment showed promising and opens new avenues for treating GBM, particularly in addressing postoperative recurrence. Statement of significanceOur research introduces a pioneering approach in treating orthotopic brain glioblastoma (GBM), characterized by inevitable tumor recurrence, poor immune infiltration and the restrictive nature of the blood-brain barrier. To break the impasse of ineffective treatment for GBM, the innovative use of dynamically reversible covalent bonds in polymer matrix ensures the controlled, stable and sustained release of drug combinations of the chemotherapeutic agent temozolomide, immune adjuvants and checkpoint inhibitors, which maintains the optimal concentration in the tumor, overcoming problems associated with conventional chemotherapy such as systemic toxicity and low tumor targeting. Empirical evidence from in vivo experiments on the rat GBM model demonstrates significant outcomes: 90 % tumor size reduction and prolonged survival with over 70 % tumor cure rate.

Deep Traps in AlN Hydride Vapor Phase Epitaxy Film on Low-Temperature AlN/Sapphire

Deep trap states were examined in c-plane, Al-polar AlN epilayers, deposited via metal organic chemical vapor deposition on 270 nm thick AlN buffer layers on sapphire substrates. Contacts were created using e-beam deposited Ni through a shadow mask, with I-V characteristics revealing a trapped limited current (TLC) regime and voltage-dependent hysteresis upon light-emitting diode illumination. Thermally stimulated current and photothermal ionization current spectroscopy measurements demonstrated a prominent trap activation energy of approximately 0.75 eV and additional trap energies of 0.6, 0.4, 0.25, 1.05, and 1.1 eV. The observed differences in photocurrent responses between forward and reverse biases suggest that forward bias induces electron trapping at deeper levels, influencing the TLC behavior. Comparisons with bulk n-type AlN crystals from previous studies show similarities in deep trap spectra, suggesting commonality in trap characteristics across different AlN samples.

Who addresses pollution? Relationships among actors and grant money for waste management efforts in remote Alaskan communities

This study discusses waste-related issues in remote Alaskan villages, focusing on the relationships between the support providers, such as government officials and nonprofits, and the indigenous people, from the perspective of self-determination. With the increasing volume and variety of waste generated by recent lifestyle changes, health and environmental issues have become growing concerns. Each village is responsible for waste management and operating a disposal site. However, challenges exist regarding the current waste management regime, highlighting the importance of grant-funded initiatives and support from non-profit organizations. Based on interviews with supporters and observations of the negotiation process between supporters and indigenous people, this study analyzes the grants and collaborative efforts in Alaska. Through grants and collaborative initiatives, the assimilation of indigenous people into mainstream society is inevitable, although efforts to respect indigenous self-determination and communication are ongoing and serve as a framework for bridging the gap between the waste regime and status quo. However, two unsolved issues remain: the “support-in-waiting” dilemma, and the issues arising from the social, economic, and geographical diversity among settlements. The balance between respect for self-determination in environmental governance and provision of support extending beyond equality of opportunity will be the key to future relationships.

A promising class of Antiprotozoal agents, design and synthesis of novel Pyrimidine–Cinnamoyl Hybrids

Malaria, caused by parasitic protozoans of the Plasmodium genus, continues to be one of the greatest global health crises, especially in Africa. The emergence of antimalarial drug resistance continues to be a health problem necessitating an urgent need for alternative and cost-effective antimalarials. Using a molecular hybridization approach, we report the design and synthesis of an efficacious novel class of antiprotozoal agents; (E)-1-(4-(4,6-diphenylpyrimidin-2-yl)piperazin-1-yl)-3-phenyl prop-2-en-1-one derivatives (8a-r). The in vitro inhibitory activity of the synthesized compounds was evaluated against the NF54 chloroquine-sensitive strain of Plasmodium falciparum. From the antiprotozoal screening, three compounds displayed propitious activity with IC50 values (0.18-0.21μM), using quinine and chloroquine as standard antimalarials. Compounds 8o and 8l emerged as the most potent candidates with IC50 values of 0.18 ± 0.02 μM and 0.21 ± 0.001 μM with an associated good safety index of 18.59 and 16.75 to human kidney epithelial (HEK293) cells, respectively. The synthesized analogues present a new chemical architecture structurally unrelated to the current regime of antimalarial drugs, representing a valid strategy to combat resistance in P. falciparum species to current commercial drugs. We further investigated the binding affinities of the compounds against recombinant forms of two P. falciparum heat shock protein 70 homologues; PfHsp70-1 and PfHsp70-z, both of which are essential and promising druggable candidates. Compound 8l exhibited the highest binding affinity for both PfHsp70s. Furthermore, molecular docking revealed that compounds 8k, 8l, 8m, and 8o exhibited better fitness to PfHsp70-1, with compounds 8l and 8o showing the highest binding affinity of 10.5 kcal/mol and 10.1 kcal/mol, respectively. Therefore, it can be speculated that PfHsp70-1 may be a possible target of some of the inhibitors tested in this study. The presence of electron-donating groups on the phenyl ring of 4,6-pyrimidine moiety and cinnamoyl group demonstrated a positive correlation between the observed computational data and the biological activity. Taken together, this paper demonstrates the importance of using the molecular hybridization approach in the development of newer cinnamoyl clubbed with 4,6-diphenyl pyrimidine hybrids as potential antiprotozoal agents.

Assessment of Pollution of the Waters in the South Kuril Fishing Zone of Russia by Radioactive Waters from the Fukushima-1 NPP Based on Lagrangian Modeling

The study investigates the potential hazard arising from the actions taken by the Japanese government regarding the discharge of technical radioactive water from the Fukushima-1 nuclear power plant storage facilities. The contamination of the South Kuril Fishing Zone (SKFZ), which is one of the most promising fishing areas for the Russian Federation, with radioactive particles, is considered. Based on the modeling of passive markers simulating radioactive contamination, the study analyzes the pathways and mechanisms of pollution transfer into the SKFZ. The research is conducted using altimetric data on geostrophic currents for the period from August 24, 2022, to August 24, 2023. The pollution transfer into the SKFZ is determined by a set of conditions related to the current development regime of the First Kuril Meander and the local vortex system with varying characteristics, both near the discharge site and at the SKFZ border. A seasonal dependence of the speed and quantity of polluted water infiltration toward the Russian Federation’s shores is established. The possibility of rapid pollution advection into the SKFZ within 13 days has been discovered. This speed is due to the entrainment of contamination by the Kuril Meander and its further transport by the mesoscale vortex system to the SKFZ border. The study reveals periodicity in the influx of pollution into the SKFZ. Graphs depicting the distribution of the quantity of “dirty” markers over their release times and the arrival of polluted water at the SKFZ border have been created.

이행청구, 강제이행, 전보배상 및 대상청구 개정안 관견(管見)

The 3rd Civil Code Revision Committee has been organized and working on the revision of contract law in the Civil Code since 2023. In this article, articles 387, 389, 395, and 399 of the draft of the revised Civil Code, which deal with right to performance, forced execution, compensatory damages, and right to surrogate benefit respectively, are introduced and analyzed. These draft provisions confirms the right to performance in principle while excludes it when the performance becomes impossible due to the obligor’s fault, deletes paragraphs on specific methods of forced execution, reorganizes the requirements for compensatory damages by assimilating them with the law of termination and with new cause for substitute damages when anticipatory repudiation and impossibility. The purpose of any of these, except for anticipatory impossibility, is to legislatively accommodate the development of cases and legal doctrines thus far or to streamline the system without changing the substance of the current regime. The revision regarding the right to surrogate benefit even left most of the controversial issues unresolved. This underlying direction is understandable in light of the various limitations that must be considered in revising the Civil Code, which has not been revised for over 65 years, especially the contract law part, which is highly versatile and involves a large number of transactions and cases.

The Adaptive Physical Activity Study for Stroke: A Feasibility Sequential Multiple Assignment Randomized Trial

Abstract Background Between 1990 and 2017, stroke cases nearly doubled, ranking as the second leading cause of death and disability globally. Inadequate physical activity (PA) is a leading risk factor. Recent guidelines advise stroke survivors to follow population-based PA guidelines. Given stroke heterogeneity personalised PA interventions are recommended. Therefore, this study used a Sequential Multiple-Assignment Randomized Trial (SMART) design to develop an adaptive mHealth intervention to improve PA post-stroke. Methods This SMART is in progress, with recruitment completed and follow-up data ending November 2024. A 12-week intervention programme was developed incorporating public patient involvement (PPI), empirical evidence and behavioural change theory to increase participation in Structured Exercise (SE), Lifestyle Physical Activity (LPA), or both. The study enrolled 54 ambulatory, community-dwelling people who were randomly assigned to either SE or LPA treatment groups. Participants used Fitbit Inspire 2 devices to monitor step counts and set personalized weekly step goals. At six weeks post-randomisation, participants were evaluated and classified as responders or non-responders based on their step count target achievement. Non-responders were re-randomized to switch treatments or augment their current regime with an additional intervention. Responders maintained their original treatment protocol. Primary outcomes address recruitment, retention and adherence rates. Secondary outcomes encompass overall health. Results Preliminary results include 54 participants (56% male) aged 51.58 (± 15.12) with Ischaemic (44%), Haemorrhagic (28%) or unknown (28%) stroke type at baseline. The mean weekly step was 7046 (±3797) while the mean Fatigue Severity Scale score was 38.02 (± 14.60). Participants had a mean Hospital Anxiety and Depression Scale score of 12.33 (± 6.98). Additionally, the mean Stroke Specific Quality of Life was 155.04 (58.84). Conclusion This is the first trial to use a SMART to design an adaptive intervention post-stroke internationally. Findings will inform the development of a PA intervention and subsequently will be evaluated against treatment as usual in a definitive trial.