The computation of one-loop corrections to Reggeon-Particle-Particle effective vertices with two scales of virtuality is considered in the framework of gauge-invariant effective field theory for Multi-Regge processes in QCD. Rapidity divergences arising in loop integrals are regulated by “tilted Wilson lines” prescription. General analysis of rapidity divergences at one loop is given and necessary scalar integrals with one and two scales of virtuality are computed. Two examples of effective vertices at one loop are considered: the effective vertex of interaction of (space-like) virtual photon with one Reggeized and one Yang-Mills quark and the effective vertex of Reggeized gluon to Yang-Mills gluon transition with an insertion of the operator tr[GμνGμν] carrying the (space-like) off-shell momentum. All terms ∼r±ϵ in the rapidity-regulator variable r cancel between diagrams and only logr-divergence is left. It is checked on several examples, that obtained results indeed allow one to reproduce Regge limit of one-loop QCD scattering amplitudes.