The pandemic has drawn attention to the unsustainable nature of tourism, intensifying social and economic inequalities and heightening issues of urban vulnerability. As destinations reimagine their future, a holistic approach that addresses social and ecological perspectives through collaboration, stewardship and environmental ethics is required. Regenerative tourism enables destination communities to develop new ways of thinking and build the capability and capacity to work towards embedding tourism practices and ecological processes that advocate human and non-human health and wellbeing. As the tourist-historic city of York, United Kingdom emerged from the pandemic, practice-led regenerative development was evident in the city’s framework for post-Covid recovery and renewal. Semi-structured interviews with leading stakeholders identified how communities can build sustainable city ecologies through living systems thinking, evidenced through collaborative models of engagement. In York, the pandemic catalysed community stewardship and a re-orientation towards a more inclusive tourism environment. This research demonstrates how regenerative practice principles manifest in the interconnections and the networks that support the distinctive qualities and needs of York’s local communities. The study also contributes to understanding how regenerative tourism approaches support cultural revival, as evident in York. Such approaches to tourism management in historic cities highlights the transformative potential of practice-led regenerative development as a tool for addressing tourism development concerns in urban spaces.