The cylindrical regenerative thermal oxidizer (CRTO) came into being later than the three-chamber regenerative thermal oxidizer (TRTO). Compared with TRTO, CRTO has a smaller size and a larger regenerator volume for absorbing and releasing heat. There are few studies on CRTO despite its numerous applications. A CRTO was selected in industrial applications for simulation research. The velocity and temperature of the CRTO were investigated after error analysis of industrial and simulated data. It was found that the velocity and temperature in the regenerative chamber had obvious stratification and gradients after homogenization by the regenerator unit. The velocity and temperature distribution in the oxidation chamber were independent of the position of the CRTO inlet and outlet or the structure below the regenerator, and there were identical periodic changes in each period. A TRTO with primary parameters as those of the CRTO was employed for comparison. The time of the intake and exhaust periods of a CRTO regenerative chamber were 30 s longer than those of a TRTO. The regenerator volume of heat storage used by CRTO for heat exchange increased by 1/6 compared to that of TRTO at the same total regenerator volume. Simulation shows that CRTO had a more uniform velocity and temperature in the regenerative chamber compared to those in TRTO, increasing by approximately 2%; the thermal efficiency is higher, with an average increase of about 3%.