This study investigates the real-time processing of Chinese reflexives ziji and ta-ziji in discourse when multiple constraints are involved. Our primary goal is to examine the time course of syntactic and non-syntactic constraints in reflexive resolution. The Syntactic Filter Hypothesis argues that syntactic cues are prioritized at the early stages of processing, in contrast to the Multiple Constraints Hypothesis which posits that at this stage all streams of information can be recruited. The results of two self-paced reading experiments show that in neutral contexts where no antecedent is discourse-prominent, syntactic locality and verb semantics immediately impact real-time processing of ziji and ta-ziji. Crucially, participants’ processing patterns are also influenced at an early stage by the discourse topical status of the non-local antecedents. Overall, these findings suggest that syntax, verb semantics, and discourse prominence all play important roles at an early stage.