An information system is a combination of software, hardware, and telecommunication networks to collect useful data, especially in an organisation. Many businesses use information technology to complete and manage their operations, interact with their consumers, and stay ahead of their competition. The purpose of this study is to analyze and investigate the strategic role of information systems in modern enterprises. We analyzes the components of information systems and their overall functions, as well as the importance of keeping the information system and organizational strategy aligned. By analyzing the influence of digital connection on enterprises, this paper expounds the adoption of information system in enterprises. We analyze the reasons why information systems have a significant impact on organizational operations, and the goals of an enterprise's adoption of information systems. The relationship between proper information system and improving the efficiency of company operation is analyzed. In business operation, small and medium-sized enterprises regard information system as a priority, and the impact of strategic information system on enterprises. From the above, we conclude the value of information systems in contemporary enterprises, increasing productivity, reducing resource use, and making data collection more efficient.