Reduction Of Signs Research Articles

Lactobacillus rhamnosus 1.0320 Postbiotics Ameliorate Dextran Sodium Sulfate-Induced Colonic Inflammation and Oxidative Stress by Regulating the Intestinal Barrier and Gut Microbiota.

Probiotics are increasingly being used as an adjunctive therapy for ulcerative colitis. However, some safety issues have been found in the clinical use of probiotics. Postbiotics have attracted much attention due to their storage stability, safety, and potential functions, but the dose required to exert a significant protective effect is unknown. Therefore, this study evaluated the potential mechanisms of different doses (200, 400, 600 mg/kg) of Lactobacillus rhamnosus 1.0320 postbiotics (1.0320P) in alleviating dextran sodium sulfate (DSS)-induced colitis. The study revealed that 1.0320P could mitigate DSS-induced colitis with signs of reductions in the disease activity index, amelioration of colon tissue damage, decreased secretion of proinflammatory cytokines, reduced oxidative stress levels, and lower bone marrow peroxidase activity. Furthermore, high dose of 1.0320P could upregulated the expression of key proteins in the Nrf2/ARE pathway (NQO1, Nrf2, and HO-1) and downregulated the expression of key proteins in the TLR4/NF-κB signaling pathway (TLR4, MyD88, and NF-κB p65). In addition, high dose of 1.0320P could upregulate the expression of tight junction (TJ) proteins including ZO-1, Occludin, and Claudin-1, contributing to the restoration of the intestinal mucosal barrier function. Additionally, 1.0320P was found to effectively correct imbalances in the intestinal microbiota and enhance the synthesis of short-chain fatty acids (SCFAs), thereby regulating homeostasis in the intestinal internal environment. Overall, our findings suggest that postbiotics could ameliorate colonic inflammation while being somewhat dose-dependent. This study provides new insights into postbiotics as a next-generation biotherapeutic agent for the treatment of ulcerative colitis and even other diseases.

Operando XANES Reveals the Chemical State of Iron-Oxide Monolayers During Low-Temperature CO Oxidation.

We have used grazing incidence X-ray absorption near edge spectroscopy (XANES) to investigate the behavior of monolayer FeOxfilms on Pt(111) under near ambient pressure CO oxidation conditions with a total gas pressure of 1 bar. Spectra indicate reversible changes during oxidation and reduction by O2 and CO at 150ºC, attributed to a transformation between FeO bilayer and FeO2 trilayer phases. The trilayer phase is also reduced upon heating in CO+O2, consistent with a Mars-van-Krevelen type mechanism for CO oxidation. At higher temperatures, the monolayer film dewets the surface, resulting in a loss of the observed reducibility. A similar iron oxide film prepared on Au(111) shows little sign of reduction or oxidation under the same conditions. The results highlight the unique properties of monolayer FeO and the importance of the Pt support in this reaction. The study furthermore demonstrates the power of grazing-incidence XAFS for in situ studies of these model catalysts under realistic conditions.

The Effects of Burst Steroid Therapy on Short-term Decongestion in Acute Heart Failure Patients With Pro-inflammatory Activation: A Post Hoc Analysis of the CORTAHF Randomized, Open-label, Pilot Trial

The effect of steroids on congestion in patients with acute heart failure (AHF) is not known. Patients with AHF, NT-proBNP levels > 1500 pg/mL and high-sensitivity C-reactive protein (hsCRP) levels > 20 mg/L were randomized to once-daily oral 40 mg prednisone for 7 days or usual care. In this post hoc analysis, congestion score was calculated on the basis of orthopnea, edema and rales (0 reflecting lack of congestion, and 9 maximal congestion) at each time point. Among 100 eligible patients randomized, those assigned to prednisone had a greater improvement in congestion score at day 31 (win odds for the prednisone group compared to usual care at day 31 was 1.77 (95% CI 1.17-2.84; P = 0.0066) in all patients and 2.41 (95% CI 1.37-5.05; P = 0.0016) in patients with IL-6 > 13 pg/mL at baseline. In patients with congestion scores ≥ 7 at baseline, the effects of prednisone therapy on the EQ-5D visual analog scale score were 4.30 (95% CI 0.77-7.83) points at day 7 and 5.40 (0.51-10.29) points at day 31, accompanied by lower heart rate and respiratory rate and higher oxygen saturation compared to usual care. In patients with AHF and inflammatory activation, 7-day steroid therapy was associated with reduction in signs of congestion up to day 31. These results need confirmation in larger studies examining potential effects of steroids on congestion, diuresis, fluid redistribution and vascular permeability as well as clinical effects in AHF.

The effectiveness of Slow Deep Breathing in DM patients who experience anxiety

Diabetes mellitus (DM) is a chronic metabolic disease characterised by persistent hyperglycemia. The etiology of the condition could stem from issues related to insulin secretion, peripheral insulin resistance, or a combination of both factors. Slow deep breathing (SDB) is abdominal breathing with a slow or slow frequency, rhythmic and comfortable which is done by closing the eyes and blowing air through the lips. SDB technique is done for 15 minutes 3 times a day, can be accomplished at any time. It is anticipated that there will be a globally recognised standard for Sleep-Disordered Breathing (SDB) procedures. This will facilitate further research utilizing larger sample sizes for more robust analysis. Aims: to detect the effect of the application of SDB to DM Type II patient experiencing anxiety during the treatment at Royal Prima Hospital. Study design: the chosen design was a quasi experiment with a case study with the use of the SPSS. The sample size comprised a singular participant meeting the criteria of Type 2 Diabetes Mellitus (DM) accompanied by comorbid anxiety and undergoing treatment for a duration exceeding 48 hours. Data collection methods encompassed interviews, interventions, observations, documentation, and subsequent evaluations. Place and Duration of Study: Royal Prima Hospital and 1 month Methodology: quantitative methods were employed, adhering to ethical guidelines that included obtaining informed consent from participants who agreed to partake as respondents. Results: after SDB intervention the blood pressure was reduced from the first examination, and the period of sleep from 4 to 6-8 hours, the patient's anxiety was reduced as well as the dizziness. The patient exhibited a noticeable reduction in signs of tension. Conclusion: Slow Deep Breathing (SDB) can reduce anxiety in DM Type II patients.

Ayurvedic management of Prameha - A Single Case Study

Diabetes mellitus (DM) type 2 is one of the global problems of the present day and it is gaining more attention. It is expected to continue as a major health problem and leads to serious complications. India is one of the top 5 countries with the highest prevalence of DM. The IDF Diabetes Atlas (2021) reports that 10.5% of the adult population (20-79 years) has diabetes, with almost half unaware that they are living with the condition. By 2045, IDF projections show that 1 in 8 adults, approximately 783 million, will be living with diabetes, an increase of 46%.[1] The signs and symptoms of diabetes can be correlated to Prameha of Ayurveda. The management of Prameha is mentioned in Ayurveda as preventive and curative aspects. Ayurveda has recommended an appropriate use of Oushadha Yogas along with proper Pathya (wholesome) Ahara, and Viharas. On the same principles a patient was treated at OPD basis, this case report analyses the same. A male patient, aged 45 years, diagnosed case of Prameha 5 years back presented with dryness in the mouth, increased frequency of micturition, Excessive thirst, weakness of the body, and burning sensation at the sole. The treatment planned was use of Shamana Oushadhis along with proper Pathya (wholesome) Ahara, and Vihara for three months. After three months of treatments results were compared. There was a marked reduction in signs and symptoms like burning sensation, numbness, excessive thirst, and increased micturition.

An upcycled fraction of Melaleuca alternifolia essential oil regenerates the skin through the skin melatonin pathway and improves sleep quality.

Sleep is one of the most important factors affecting overall health. During the night, the skin repairs damage caused by daily stresses. Melatonin plays a key role in this process. Toxins are removed, and cellular repair and growth hormone production are increased. Inter alia, this also decreases signs of intrinsic aging. The current study was intended to demonstrate the impact of a unique fraction of Melaleuca alternifolia (FMA) essential oil, on sleep and skin quality. The effect of FMA was investigated invitro on skin cells, evaluating its antioxidant and anti-inflammatory properties, and in an ex-vivo study on human skin biopsies treated with FMA following stress induction. In addition, two clinical studies were performed on volunteers with life-style-related sleep complaints. In one study, sleep was measured using a noncontact monitoring device (SleepScore Labs, Max). A second study was conducted to assess skin anti-aging effects. In vitro application of FMA reduced IL-8 and reactive oxygen species (ROS) generation in skin cells. This was confirmed exvivo through a decrease in inflammatory markers and an increase in antioxidant enzymes after stress induction. Interestingly, FMA also upregulated melatonin-associated genes. Real-world sleep tracking revealed that FMA significantly improved sleep quality, relative to unscented control. Invivo applications also showed a reduction in signs of aging. These results provide initial data to suggest that this unique FMA delivers skin anti-aging benefits via a two-pronged mode of action, improving sleep quality, and reducing skin inflammatory and oxidative stress.

Comparative study of efficacy and safety profile of topical preparations of alcaftadine 0.25% and olopatadine 0.2% eye drops in patients of allergic conjunctivitis – A prospective cohort study

Background: Allergic conjunctivitis, causing eye inflammation and redness, requires effective treatment with alcaftadine 0.25% and olopatadine 0.2% eye drops. Aims and Objectives: The aim of the study was to compare the efficacy and safety of alcaftadine and olopatadine ophthalmic medications in mild-to-moderate allergic conjunctivitis. Materials and Methods: A prospective, open-label, comparative study of 60 patients randomized into two study groups of 30 patients each. Each group was assigned to receive either olopatadine or alcaftadine ophthalmic solutions. Patients were followed through at regular intervals with a reduction of signs and symptoms documented using total ocular symptom scoring (TOSS) and hyperemia scale systems. Results: Baseline (1st visit) mean TOSS scores for the alcaftadine group and olopatadine groups were (6.12±1.92) and (6.32±1.80), respectively, as compared to the corresponding TOSS scores on 14th Day (4th visit) which were (0.5±0.11) and (0.9±0.40), respectively. The resolution of conjunctival symptoms in the alcaftadine group was significantly profoundly as comparison to olopatadine group (P = 0.004). Baseline (1st visit) mean hyperemia scores for alcaftadine group and olopatadine groups were (2.1±1.71) and (2.2±1.52), respectively, as comparison to the corresponding hyperemia scores on 14th day (4th visit) which were (0.08±0.01) and (0.6±0.32), respectively. The resolution of hyperemia symptoms in the alcaftadine group was significantly profound as compared to the olopatadine group (P = 0.002). Conclusion: Two topical medications utilized in the study were effective and safe for the therapy of allergic conjunctivitis. However, alcaftadine appears to surpass olopatadine in alleviating the symptoms of allergic conjunctivitis while having a lower side effect profile.

Radial Head and Neck Ostectomy Maintained Elbow Joint Function in a Labrador Retriever with Type 1 Congenital Elbow Luxation

AbstractA 6-month-old Labrador Retriever was diagnosed with a Type 1 caudolateral congenital right elbow luxation. A radial head and neck ostectomy was performed with no surgical attempt to further stabilize the elbow joint. One year after surgery, objective gait analysis showed only a mild asymmetry in peak vertical forces. Pre- and postoperative Liverpool Osteoarthritis in Dogs scores showed a decrease in perceived pain and a reduction in signs of osteoarthritis. In dogs with congenital radial head luxation, a radial head and neck ostectomy without surgical joint stabilization may be a viable, simple option for a one-time intervention that can reduce pain and signs of secondary osteoarthritis and improve limb function.

PECULIARITIES IN CORRECTING ANXIETY AND DEPRESSIVE DISORDERS IN CARE-GIVERS FOR SERIOUSLY ILL PATIENTS WITH CANCER

The challenges faced by families of patients with cancer can be categorized into three main groups: emotional disorders in caregivers, behavioral changes, and problems related to the care and treatment system. Emotional disorders encompass anxiety, uncertainty about the patient's health, and a pervasive sense of helplessness. Behavioral changes involve shifts in family roles and lifestyle, intensified care-giving responsibilities, particularly in the later stages of treatment, and financial hardships stemming from the costs of anticancer treatment. Systemic challenges in care and treatment further compound the difficulties experienced by the family unit. Anxiety and depressive disorders were detected in 69.3±3.8% of relatives of patients with malignant neoplasms. To correct emotional disorders in caregivers for patients with cancer, a correctional complex was proposed, which included a combination of rational, short-term positive, cognitive-behavioral and family psychotherapy with psychopharmacotherapy. Under the influence of the proposed complex for the correction of anxiety-depressive disorders in caregivers, a significant decrease in the severity of symptoms of depression (MADRS, p<0.05) and anxiety (HAM-A) was noted after 4 weeks. This was clinically manifested by a subjective improvement in mood, a decrease in the amplitude of fluctuations in affective disorders, diminished signs of emotional labiality, improved sleep, increased productivity in everyday activities, and a reduction in signs of anxiety. The proposed intervention demonstrated its efficacy in positively impacting the well-being of caregivers, highlighting the importance of a multifaceted approach to address the complex challenges faced by families in the context of cancer care.

Experimental assessment of cork based Botryococcus braunii microalgae blends and hydrogen in modified multicylinder diesel engine

The extended research in using non-edible sources for production of biodiesel has been a boon in today’s need for an alternative fuel. However, the advanced biodiesels have helped to be an alternative fuel to tackle the fossil fuel shortage, the further improvements are needed in the composition of biodiesels. The present research paper gives the detailed explanation about the conversion of the Botryococcus braunii microalgae oil into biodiesel. In addition to the biodiesel blends, hydrogen was added to the injection system as secondary fuel. The addition of hydrogen in biodiesels will reduce the emission of unwanted pollutants. The hydrogenation increases the cetane number of the biodiesel and reduces the free fatty acids to improve the fuel quality. Experimental tests were conducted at full load condition by varying the engine speed from 1000 rpm to 3000 rpm. The hydrogen supply was provided constantly by allowing 5 L per minute into the BB (Botryococcus braunii) biodiesel. The varied proportions of biodiesel was BB0 (Diesel 100 %), BB10 (Botryococcus braunii biodiesel 10 %+Diesel 90 %) and BB20 (Botryococcus braunii biodiesel 20 %+Diesel 80 %) assisted with hydrogen to form BB0H5, BB10H5 and BB20H5. Blends were tested in a multi cylinder, naturally aspirated, compression ignition diesel engines. The different characteristics of the biodiesel with hydrogen in terms of performance, combustion and emission were calculated. The highest engine torque was reported when engine speed was maintained at 1500 rpm. BB10H5 reported the maximum engine torque of 282 Nm followed by BB20H5 and BB0H5. All the blends with hydrogen enrichment reported the highest thermal efficiency and reduced brake specific fuel consumption. Compared to plain diesel, the hydrogen added biodiesel significantly reduced the harmful gas emissions meanwhile the performance qualities were improved. However, there is no sign of reduction in the NOx across various engine speed due to the high cylinder temperatures at higher engine speeds.

Revisão sistemática: o uso de probióticos gera benefícios para pacientes em tratamento de doenças inflamatórias intestinais?

Objectives: To review the literature that assesses whether the use of probiotics generates benefits for individuals with IBD and to describe the mechanisms of action of probiotics in the pathogenesis of inflammatory bowel disease. Methods: This is a study classified as a systematic review. The selected publications were submitted to the Jadad Scale criteria to assess methodological quality. 15 articles were selected. Results: Of the five clinical trials that used placebo, only 1 did not show benefits from the use of probiotic therapy. The remainder showed a reduction in signs and symptoms and acute phase reagents or induction of remission in the groups treated with probiotics compared to placebo. Conclusion: The present systematic review suggests that the use of probiotics is beneficial in patients with IBD.

Fogging is a Puerile Exercise: A Preliminary Study Done in the City of Kolkata, India, Following the Outbreak of DF/DHF in 2017, Has Revealed

In 2017, the impact of fogging on transmission of dengue was studied in Kolkata City, India. As revealed, the measure failed to yield any positive results. Despite the massive fogging being carried out in different municipal wards, no sign of reduction in the number of dengue cases was visible. At the behest of Atin Ghosh, deputy mayor [erstwhile mayoral council member [health] of Kolkata Municipal Corporation, the fogging was banned in 2019 and an era of vector management by applying all possible means of source reduction brought in.

Plain language summary of the CARTITUDE-1 study of ciltacabtagene autoleucel for the treatment of people with relapsed or refractory multiple myeloma.

This is a summary of a clinical study called CARTITUDE-1. This study tested the anti-cancer chimeric antigen receptor-T cell (CAR-T) therapy ciltacabtagene autoleucel, abbreviated as cilta-cel, in people with multiple myeloma, a cancer that affects a specific type of blood cell called plasma cells. The participants in this study had relapsed or refractory disease, which means that their cancer did not improve or returned after 3 or more previous anti-cancer treatments. Ninety-seven participants went through the treatment process, which included collecting participants' own T cells (a type of immune cell), genetically modifying those T cells to recognize a certain protein found on myeloma cancer cells, pretreating with chemotherapy to prepare the participant's immune system to accept the modified T cells (cilta-cel), and finally injecting cilta-cel. Ninety-eight percent of participants showed decreases in indicators of cancer after treatment with cilta-cel. Seventy percent of participants were still alive approximately 28months after treatment, and 55% of participants were still living without their cancer getting worse. The most common side effects were low blood cell levels, infections, cytokine release syndrome (a potentially serious side effect caused by overactivation of the immune system), and side effects that involved the nervous system (called neurotoxicities). Some participants experienced late-onset symptoms of neurotoxicity like the signs and symptoms of parkinsonism, meaning that they affected people's movement. Improvements in recognition of factors that increase the risk of these late-onset neurotoxicities and strategies to help avoid them has reduced their occurrence, although long-term monitoring for side effects is still an important part of treatment. Overall, almost all participants treated with cilta-cel had long-term reductions in signs of myeloma, and the majority of participants were alive and had no detectable signs of cancer over 2years after being injected with cilta-cel. Clinical Trial Registration: NCT03548207 (1b/2 CARTITUDE-1 study) NCT05201781 (Long-term Follow-up Study for Participants Previously Treated With Ciltacabtagene Autoleucel).

Classical Music Therapy on Decreasing Auditory Hallucinations for Mental Disorder Patients

Auditory hallucinations are one of the symptoms of mental disorders in which individuals experience sensory-perceptual changes that need to get treatment as soon as possible. To overcome the problem of auditory hallucinations, this can be done through music therapy. The aim of the study was to determine the effect of classical music therapy on reducing auditory hallucinations in patients with mental disorders. The research method used a quasi-experimental pre-post test. The sample in this study were 30 people. The results of statistical analysis using the paired t-test showed a p-value of 0,000, which means that there was an effectiveness of classical music therapy in reducing signs and symptoms of auditory hallucinations. The conclusion is that there is an effect of the effectiveness of classical music therapy on the reduction of signs and symptoms in patients with auditory hallucinations at the Dadi Mental Hospital Makassar.

Effectiveness of photodynamic therapy (PDT) in the management of symptomatic oral lichen planus -A systematic review.

Oral Lichen Planus (OLP) is a chronic mucocutaneous inflammatory disease of unknown aetiology characterized by T cell mediated autoimmune response which trigger apoptosis of basal cells of an oral epithelium. Corticosteroids are the primary therapeutic option for symptomatic OLP however treatment of lesions unresponsive to corticosteroids that tend to recur are becoming challenging for the clinicians. Currently photodynamic therapy (PDT) is being explored as a new curative option for reduction of pain and/or burning sensation associated with OLP lesions. The aim of this systematic review was to analyse studies from literature on the therapeutic effectiveness of PDT in management of symptomatic OLP unresponsive to corticosteroid therapy. The electronic retrieval systems and databases PUBMED [MEDLINE], EMBASE, SCOPUS, WEB OF SCIENCE, GOOGLE SCHOLAR, and SCIENCE DIRECT were searched independently by two authors for relevant articles from January 2015 till July 2021. Primary studies focussed on the role of PDT in treatment of symptomatic OLP and published in English were included. Out of the 370 articles, only ten studies met the selection criteria. Included studies demonstrated PDT as an effective alternative modality to treat symptomatic OLP with no drop outs. In all studies, with PDT reduction in lesion size and VAS score was observed during each follow up sessions and after treatment (approx. 12 weeks) when compared to pre-treatment level (p<0.001). Four studies noted PDT to be more effective than topical corticosteroids in reduction of signs and symptoms of OLP (p=0.001). In the future, long-term studies on larger population should be conducted to establish the clinical effectiveness in PDT in symptomatic OLP. Studies should take into consideration different sources of light and photosensitizers to determine the ideal parameters of PDT treatment for OLP. Wavelength is the most important factor in all types of photo therapies, so the most appropriate wavelength should be selected to obtain better outcome.

Efficacy of Plantar Orthoses in Paediatric Flexible Flatfoot: A Five-Year Systematic Review

Paediatric flexible flatfoot (PFF) is a very common condition and a common concern among parents and various healthcare professionals. There is a multitude of conservative and surgical treatments, with foot orthoses (FO) being the first line of treatment due to their lack of contraindications and because the active participation of the child is not required, although the evidence supporting them is weak. It is not clear what the effect of FO is, nor when it is advisable to recommend them. PFF, if left untreated or uncorrected, could eventually cause problems in the foot itself or adjacent structures. It was necessary to update the existing information on the efficacy of FO as a conservative treatment for the reduction in signs and symptoms in patients with PFF, to know the best type of FO and the minimum time of use and to identify the diagnostic techniques most commonly used for PFF and the definition of PFF. A systematic review was carried out in the databases PubMed, EBSCO, Web of Science, Cochrane, SCOPUS and PEDro using the following strategy: randomised controlled trials (RCTs) and controlled clinical trials (CCTs) on child patients with PFF, compared to those treated with FO or not being treated, assessing the improvement of signs and symptoms of PFF. Studies in which subjects had neurological or systemic disease or had undergone surgery were excluded. Two of the authors independently assessed study quality. PRISMA guidelines were followed, and the systematic review was registered in PROSPERO: CRD42021240163. Of the 237 initial studies considered, 7 RCTs and CCTs published between 2017 and 2022 met the inclusion criteria, representing 679 participants with PFF aged 3-14 years. The interventions of the included studies differed in diagnostic criteria, types of FO and duration of treatment, among others. All articles conclude that FO are beneficial, although the results must be taken with caution due to the risk of bias of the included articles. There is evidence for the efficacy of FO as a treatment for PFF signs and symptoms. There is no treatment algorithm. There is no clear definition for PFF. There is no ideal type of FO, although all have in common the incorporation of a large internal longitudinal arch.

Efficacy of Juglans regia extract as a mouthwash in the treatment of periodontal disease

The study was aimed to evaluate the efficacy of Juglans Regia extracts in treatment of periodontal diseases. An extract of Juglans regia bark was preparation by mixing Juglans regia bark powder with distilled water. Phytochemicals tests were carried out for all the extract, detection of glycosides, tannins, terpenes, Steroid, Anthraquinones and, coumarines, alkaloids and saponins. 51 patients suffering from gingivitis were subjected to an experiment for 28 days, the parameters used were Gingival Index (GI), percentage of bleeding on probing (BOP) and presence of inflammatory signs and symptoms. The results show that the group that received the extract was superior compared to the chlorohexidine group, and the patients recovered at a greater rate, with reduction in signs as redness, swelling and pain, also any clinical signs or side effects.

Characterization and Sensory Evaluation of a Cosmeceutical Formulation for the Eye Area with Roasted Coffee Oil Microcapsules

The objective of this work was to characterize a cosmeceutical formulation for the eye area with roasted coffee oil microcapsules (MOF) and evaluate the acceptance and effects of its use by consumers. MOF had 3% microcapsules produced by complex coacervation; a basic formulation (BF) was used for comparison. The addition of microcapsules did not affect the pH (4.52), density (0.99 g mL−1), consistency (0.77 N s), and viscosity index (0.25 N s) of the formulation. However, a reduction in spreadability, firmness, and cohesiveness was observed. The 58 assessors received one kit with the formulations and a notebook with instructions to carry out the tests at home. They were instructed to apply the cream for 28 days and evaluate the attributes of application and treatment effects on 7-point category scales. The effect of oil addition observed in the physical tests was not sensorially perceived for spreadability and tackiness (6.0 and 5.6, respectively), indicating approval and easiness of application. The perception of the benefits (increase in smoothness, hydration, firmness, elasticity, and skin general appearance, and reduction in signs of fatigue and wrinkles/fine lines) was similar comparing MOF and BF. In conclusion, the coffee oil microcapsule is a viable ingredient for dermocosmetics with sensory acceptance.

Comparison of Power versus Manual Toothbrush in Reducing Gingivitis

Introduction: Dental plaque is a bacterial biofilm consisting of complex communities of bacterial species. Materials and Methods: The study was a single-blind, parallel arm, randomized, controlled interventional trial. Total 46 male and female subjects (32 female and 16 males) with a mean age of 26 years were enrolled according to the admission criteria and accepted into this study. The subjects were assigned to either the powered brush or the manual brush based on levels of inflammation (% BOP, MGI-52), and plaque levels (53, 54, 55) using screening data. Results: BOP decreased from baseline 22% to 17% at 2 weeks and 16% at 4 weeks for Power users (Group A). For Manual users (Group B), BOP decreased from baseline 27% to 21% at 2 weeks and 19% at 4 weeks; so both groups had a reduction in BOP but there was no statistical significance for either group. Conclusion: Both groups demonstrated a reduction in signs of gingivitis (BOP and GI) in this non-flossing population after being repeatedly trained in toothbrush use over a 4-week period. Both toothbrushes were equally effective in reducing overnight plaque as a single use exercise after initial professional training.

Effect of Different Dosage Form of Saindhavadiyoga in the Management of Computer Vision Syndrome: A Pilot Study

Eyes have a unique position among all the sense organs. Primary importance has been given for the protection of eyes by ancient Indian scholar because without eyes whole world is full of darkness. With the advancement of science development of many electronic gadgets like computer mobile etc, which has been produce new diseases. Among those diseases computer vision Syndrome is one of them. In modern system there is no permanent cure of CVS. In Ayurvedic text there is no description of Computer Vision Syndrome but it can be a Anukta vyadhi as describe by a Charak. Some of ocular symptoms of computer vision syndrome can be correlated with Sushkaksipaka as describe by Acharya sushrut and A.Hridya. Modern medicine do not have a definite treatment for this problem except lubricating eye drops whereas Ayurvedic kriyakalpas that is Ayurvedic local ocular therapies could suggest definite treatment to cure the computer vision syndrome along with the change in working style and correction of refractive error. Drugs which are describe in the treatment of Suskhakshipaka have potent property to reduce the clinical features of CVS. So in this clinical trial, I have used different dosage form of Saindhavadiyoga in the management of CVS. Study was conducted among the BHU computer professionals and all the patient were divide in the three group. In the group A eye drop and Anjana of Saindhavadi yoga was given, in the Group B only Carboxy Methyl Cellulose eye drop was given while in the group C only Tarpan therapy was given with Saindhavadighrita All the group have positive result results in reduction of signs and symptoms of CVS without any side effect which are produce by the preservative of Artificial tear drops. But in the group C have better results in comparison to other two group, it was occur due to oleation, nutritive antioxidant property of Ghrita and Yogvahi property of Ghrita which increase the bioavailbilty of drug along with other content of the drug.