Nigerian smallholder farmers suffer huge losses on annual basis in terms of monetary value as a result of postharvest losses due to factors such as inadequate storage/processing facilities, poor transportation system, lack of power supply and unorganized marketing network. With the largest population on the African continent and a spiraling increase, a corresponding increase in food supply is inevitable. The food security situation in Nigeria is already challenged by a growing pressure on land and water resources due to population increase, farmers-herders clashes and terrorism which has adversely disrupted farming activities particularly in the northeastern part of the country. With all these challenges, high loss of farm produce due to post-harvest loss is indeed another great threat to the attainment of food security in Nigeria. This paper focused primarily on postharvest losses which are like a recurring decimal in Nigeria’s agricultural sector, it discussed the driving factors, highlights its impacts and suggest some viable solutions and measures that can be adopted to tackle the problem with a view of increasing farmer’s income and ensuring food security in Nigeria. Keywords: Post-harvest loss, Smallholder farmers, Livelihood, Food security and Nigeria. DOI: 10.7176/JBAH/11-22-04 Publication date: November 30 th 2021