Won Kyu Choi, Sang Ho Lee, Seoul, South KoreaIntroduction: Spondylolytic spondylolisthesis and multiple degenerative spondylolisthesis are common lumbar spinal disorders, which display symptoms characteristic of both spinal instability and stenosis. There may be several surgical options considered, such as anterior lumbar interbody fusion (ALIF), posterior lumbar interbody fusion (PLIF), posterolateral fusion with pedicle screw fixation (PF), PLIF and PF. PLIF and PF are generally considered to provide the highest level of stability, as well as decompression. However, the procedures require wide dissection of normal tissue and excessive neural retraction, which cause increased blood loss, intraspinal neural injury and fibrosis, increased postoperative pain and recovery time. We report on the usefulness of the percutaneous PF (PPF) in augmenting the minimally invasive ALIF (mini-ALIF) for spondylolytic spondylolisthesis and multiple degenerative spondylolisthesis.Methods: We treated 20 symptomatic patients with mini-ALIF and PPF within a relatively short time span. Seventeen patients received one-level lesions, two patients received two-level lesions and one patient three-level lesions, which were confirmed radiologically by plain X-ray, computed tomography (CT) and magnetic resonance imaging.Results: Plain postoperative X-rays and CT scan were taken for all patients to analyze and determine the placement of pedicle screws and the degree of reduction of spondylolisthesis. Most preoperative spondylolisthesis was corrected in all cases. In two cases, the lateral cortical walls of the vertebral body were broken by the screws during slippage reduction and were intraoperatively repaired with bone cement, and screws were re-inserted with some adjustments, making a sound purchase. One screw violation of the inferior pedicle wall in an osteoporotic patient, which was noted intraoperatively, was left because of the possibility of the screw loosening. All but three patients could get out of bed with a brace soon after the operation. The three patients had multiple lesions. Preoperative leg symptoms were reduced considerably immediately after the operation, although surgical back pain persisted for a much longer period of time. One patient had considerable postoperative knee pain, believed to be caused by excessive reduction of L4–5 grade 2 spondylolisthesis. The knee pain gradually diminished over a period of 1 month. Besides the postoperative complications, there were pains in the iliac bone graft site in all cases.Conclusion: Spondylolytic spondylolisthesis and multiple degenerative spondylolisthesis can be treated with mini-ALIF and PPF without using a posterior neural decompressive procedure. PPF not only has the advantages of minimally invasive surgery, but also is not inferior to open conventional screw fixation in terms of accuracy of the screw placement, reduction of slippage and manageability of intraoperative complications, such as cortical bone breakage.