Several factors in glass slide (GS) preparation affect the quality and data volume of adigitized histological slide. In particular, reducing contamination and selecting the appropriate coverslip have the potential to significantly reduce scan time and data volume. To objectify observations from our institute's digitization process to determine the impact of laboratory processes on the quality of digital histology slides. Experiment1: Scanning the GS before and after installation of acentral console in the microtomy area to reduce dirt and statistical analysis of the determined parameters. Experiment2: Re-coverslipping the GS (post diagnostics) with glass and film. Scanning the GS and statistical analysis of the collected parameters. The targeted restructuring in the laboratory process leads to areduction of GS contamination. This causes asignificant reduction in the amount of data generated and scanning time required for the digitized sections. Film as acoverslip material minimizes processing errors in contrast to glass. According to our estimation, all the above-mentioned points lead to considerable cost savings.