Percent Reduction Research Articles

Efficacy of Glycyrrhizin as an Intracanal Medicament on Bacterial Load Reduction in Primary Infected Root Canals: A Randomized Clinical Trial.

This study was done to clinically investigate the efficacy of glycyrrhizin-based intracanal medication (ICM) compared to calcium hydroxide Ca(OH)2 and Ledermix on the bacterial counts inside the root canals of necrotic teeth with chronic periapical periodontitis. Thirty-six patients having single-rooted and single-canaled necrotic teeth with chronic periapical periodontitis were enrolled in this research. Aseptic control measures were taken before clinical steps. Access cavity preparation was done. First bacteriological samples (S1) were collected immediately after access cavity preparation and before cleaning and shaping inside the root canals. Cleaning and shaping were performed on the root canals. Patients were randomly allocated into 3 groups according to the type of intracanal medicament used [Ca(OH)2, Ledermix, Glycyrrhizin]. Second bacteriological samples (S2) were collected after 1 week from placing the ICMs. S1 and S2 were transferred to the lab of microbiology for culturing on blood agar dishes in anaerobic conditions, and the bacteria on the plates were enumerated as colony-forming units (CFUs) by the manual counting method. The anti-bacterial efficacy of the ICM was estimated by the percentage reduction in the bacterial colonies from S1 to S2. All tested ICM documented a significant reduction in the CFUs from S1 to S2 (p < 0.05). Regarding S1, there was no significant difference between the three tested materials (p > 0.05). Regarding S2, Glycyrrhizin and Ledermix showed significantly lower CFUs than Ca(OH)2. There was no significant difference between Glycyrrhizin and Ledermix. Under the conditions of the present study, Glycyrrhizin and Ledermix showed comparable antimicrobial effects that were better than the commonly used Ca(OH)2 ICM. Glycyrrhizin may be a promising ICM. Herbal medicine can be considered as an alternative antimicrobial material for root canal disinfection because it has many benefits, like low toxicity, absence of microbial resistance, and favorable antimicrobial efficacy. This study highlights the clinical efficacy of Glycyrrhizin as a promising ICM. How to cite this article: Eltantawi AR, Abdel-Razik GM, Elhawary YM, et al. Efficacy of Glycyrrhizin as an Intracanal Medicament on Bacterial Load Reduction in Primary Infected Root Canals: A Randomized Clinical Trial. J Contemp Dent Pract 2024;25(6):540-546.

Comparative Evaluation of Platelet-rich Fibrin and Treated Dentin Matrix in Regenerative Endodontic Treatment of Nonvital Immature Permanent Teeth: A Randomized Clinical Trial.

Clinical and radiographic evaluation of the efficacy of platelet-rich fibrin (PRF) and treated dentin matrix (TDM) in regenerative endodontic treatment and periapical healing of nonvital immature permanent teeth with chronic apical periodontitis. Twenty-four children aged between 7 and 11 years, each presenting with a nonvital immature permanent upper central incisor, were selected. They were randomly allocated into two groups (n = 12), group I (PRF) and group II (TDM). Baseline clinical findings were recorded, and preoperative cone-beam computed tomography (CBCT) was taken. Follow-up was done clinically for 15 months at 3-month intervals (3, 6, 9, 12, and 15 months), and CBCT was taken at the end of the 15-month follow-up. Root length, apical diameter, radiographic root area (RRA), and size of the periapical lesion were quantitively assessed at the end of follow-up period and compared to the preoperative CBCT. Clinical success was 100% in both groups by the end of the follow-up period. Radiographically, after a 15-month follow-up, there was a significant increase in root length and RRA, and there was also a significant reduction in apical diameter and lesion size within each group (p < 0.05). However, there was no statistically significant difference between both groups regarding the mean percentage of increase in root length and mean percentage of reduction of apical diameter (p > 0.05). On the other hand, PRF showed more increase in RRA and more reduction in lesion size, with a statistically significant difference between both groups (p < 0.05). Both PRF and TDM were clinically successful. Platelet-rich fibrin showed better radiographic outcomes and periapical healing. Platelet-rich fibrin is a viable scaffold to aid further root development and resolution of periapical lesions of nonvital immature permanent teeth. Further studies with different forms of TDM are needed to assess the efficacy of TDM in regenerative endodontic treatment of nonvital immature permanent teeth. How to cite this article: Asal MA, Elkalla IH, Awad SM, et al. Comparative Evaluation of Platelet-rich Fibrin and Treated Dentin Matrix in Regenerative Endodontic Treatment of Nonvital Immature Permanent Teeth: A Randomized Clinical Trial. J Contemp Dent Pract 2024;25(6):563-574.

Synthesis and antibacterial activity of silver doped zinc sulfide/chitosan bionanocomposites: A new frontier in biomedical applications

Numerous microbial species have caused infectious diseases worldwide, which have become a social burden and a menace to the community. So, there is a need to develop antimicrobial materials and specialized materials for biomedical applications. In the present investigation, we report the simple synthesis, the physicochemical, and antibacterial activity of Silver doped zinc sulfide (ZnS: Ag) capped with Chitosan (CS) to produce ZnS: Ag/CS bionanocomposites (BNCs). The prepared BNCs was evaluated by X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR), field emission scanning electron microscopy (FESEM), energy dispersive X-ray (EDX) mapping, and UV–Vis spectroscopy. According to the XRD results, ZnS: Ag/CS particles with semicrystalline chitosan/hexagonal ZnS phase structures and an average crystallite size in the range of 30–40 nm was formed. According to FESEM images, a spherical/hexagonal shape of ZnS: Ag particles embedded in the polymeric chitosan matrix. The colony counting method was employed to investigate the antibacterial activity on Gram-positive (Staphylococcus aureus) and Gram-negative (Escherichia coli) bacteria. The results revealed that ZnS: Ag particles and ZnS: Ag/CS BNCs have stronger antibacterial activities than pure CS and ZnS. The reduction percentage of ZnS: Ag/CS BNCs against S. aureus and E. coli after 6 h of treatment was >99.9 % and 70 % respectively. These findings suggest that ZnS: Ag/CS BCs not only offer superior antimicrobial properties compared to individual ZnS and CS but also have great potential for advancing biomedical applications due to their enhanced antibacterial performance. The simplicity of the synthesis method and the use of non-toxic materials like chitosan make this a sustainable approach for developing antimicrobial agents, which is a key advantage of this study.

A Comparative Analysis of Low-Density Lipoprotein Cholesterol (LDL-C)-Lowering Activities of Bempedoic Acid, Inclisiran, and PCSK9 Inhibitors: A Systematic Review.

Newer drugs, such as bempedoic acid, inclisiran, alirocumab, and evolocumab have recently been introduced for dyslipidemia. This systematic review aims to perform a comparative analysis of these drugs' low-density lipoprotein cholesterol (LDL-C)-lowering activities. The PubMed database was utilized to search for randomized controlled trials. Articles were screened and selected based on specific inclusion and exclusion criteria. The primary outcome of this review is to compare the percentage reduction of LDL-C and apolipoprotein-B, along with the number of reported serious adverse events (SAEs) in trials specific to each drug. A total of 14 studies were included, four for bempedoic acid and alirocumab and three for evolocumab and inclisiran. The maximum percentage reduction in LDL-C and apolipoprotein-B from baseline to 12 weeks was observed with alirocumab, administered at 150 mg subcutaneously twice weekly for 12 weeks, achieving reductions of 72.4% and 57.9%, respectively. Lesser reductions were observed with bempedoic acid, administered at 180 mg once daily orally for 12 weeks. The highest number of SAEs were reported with bempedoic acid (216, 10%) and inclisiran (181, 11%; 175, 11%). This systematic review showed that alirocumab achieved the greatest reductions in LDL-C and apolipoprotein-B and a better safety profile. Newer LDL-C-lowering drugs show promise in improving lipid profiles, patient compliance, and safety. However, these findings are not conclusive, as other factors also influence treatment choice.

Surgical treatment delay in patients with headache disorders and neuralgia correlates with poor postoperative outcome

Although nerve decompression surgery has proven to be effective in reducing symptoms in patients with head and neck neuralgia and headache disorders, it is currently not part of the treatment algorithms for headache disorders. Therefore, patients wait an average of 20 years from the onset of symptoms to surgery, resulting in high conservative treatment costs ($989,275.65 per patient) and patient morbidity. This study evaluated the clinical impact of treatment delays on surgical outcomes. Overall, 282 patients who underwent nerve decompression surgery at Weill Cornell Medicine and Massachusetts General Hospital between September 2012 and January 2024 were enrolled. Information regarding demographics, onset of symptoms, and headache characteristics was collected using patient surveys. The treatment outcome was evaluated by the percentage of symptom reduction in terms of frequency, duration, and pain intensity. An area under the receiver operating characteristic analysis was performed to determine the optimal timepoint to undergo surgery. Postoperative symptom reduction and time between the onset of symptoms and surgery were negatively correlated (r=-0.22; p<0.001). The most significant difference in outcome was found at 2.9 years from symptom onset; patients who underwent surgery before this timepoint reported an average improvement of 79±23% versus 67±35% in those who were treated after the timepoint (p=0.021). Our results indicate that delays in undergoing nerve decompression surgery beyond 2.9 years from symptom onset leads to less favorable postoperative outcomes, underscoring the need for timely referral to peripheral nerve surgeons when conservative management fails. Nonetheless, even with delays in surgical intervention, patients continued to experience significant symptom reduction.

Agricultural and rural development interventions and poverty reduction: Global evidence from 16 impact assessment studies

Agricultural and rural development interventions can reduce global poverty by providing growth-oriented tools, including access to finance, training, and markets. While such interventions effectively reduce monetary poverty (e.g., $1 a day poverty line), there is increasing interest in incorporating non-monetary poverty indicators, such as education, health, and living standards, to capture inherent multidimensionality in poverty. This study analyzes data from 16 impact evaluation studies conducted between 2019 and 2023 to examine whether and to what extent agricultural and rural development interventions affect multidimensional poverty of small-scale producers. Our analysis shows a 4 percent reduction in multidimensional poverty for treatment households compared to comparison households. Our findings suggest that agricultural and rural development interventions play a positive role in reducing poverty and have the potential to improve the long-term well-being of poor households.

Leveraging an EHR tool to improve provider adherence to the modified brain injury guidelines

IntroductionThe aim was to leverage electronic health record (EHR) smartphrases to improve compliance with the modified Brain Injury Guidelines (mBIG). MethodsSmartphrases were developed for the trauma team and radiology and implemented December 2022. Traumatic brain injury (TBI) patients meeting mBIG inclusion from 03/2021- 07/2023 were reviewed. Smartphrase usage and clinical compliance with mBIG (measured by percent reduction of repeat head imaging, ICU admissions, and neurosurgery consults) were compared pre- and post-intervention. Results268 cases were examined. Post-intervention, mBIG1 patients had significantly fewer neurosurgery consults (82.4 ​% vs. 50.0 ​%, OR ​= ​0.21, p ​= ​0.03), while mBIG2 patients had significantly fewer repeat head CTs (91.0 ​% vs. 66.7 ​%, OR ​= ​0.2, p ​= ​0.01), ICU admissions (66.7 ​% vs. 38.5 ​%, OR ​= ​0.31, p ​= ​0.02) and neurosurgery consults (93.9 ​% vs. 56.4 ​%, OR ​= ​0.08, p ​< ​0.01). ConclusionStandardized smartphrases can streamline workflow and significantly improve trauma team compliance with best practice guidelines for TBI and reduce unnecessary imaging, consults, and costly ICU admissions.

Efficiency of Neoseiulus californicus (McGregor) (Acari: Phytoseiidae) for controlling three plant-feeding mites on guava trees in Egypt

ABSTRACT Tegolophus guavae (Boczek), Brevipalpus phoenicis (Geijskes), and Tetranychus urticae Koch are plant-feeding mite pests that cause severe damage to the foliage and fruits of guava trees in Egypt. The phytoseiid mite, Neoseiulus californicus (McGregor), was released at three densities (100, 200, and 300 predators/tree). The results indicated that the efficiency of N. californicus was significantly influenced by the release rate. The highest mean reduction percentage after six months of release for T. guavae, B. phoenicis, and T. urticae was, respectively, at 300 predators/tree (64.90, 81.15, and 81.11%) in 2021 and (74.89, 83.76, and 83.07%) in 2022. The mean fruit yields (kg/treatment) in the released plots were substantially greater than those in the control (ranging from 8–16%). The current result suggests that releasing N. californicus is a viable option for biological guava mite pest management.

Using cerebral regional oxygen saturation and amplitude-integrated electroencephalography in neonates on extracorporeal membrane oxygenation: preliminary experience from a single center

ObjectiveThis study aims to evaluate the application value in neurological outcome of cerebral regional oxygen saturation (CrSO2) and amplitude-integrated electroencephalography (aEEG) monitoring during neonatal extracorporeal membrane oxygenation (ECMO) courses.Methods We retrospectively analyzed 18 neonates receiving veno-arterial ECMO (V-A ECMO) support at our hospital from July 2021 to December 2022. Continuous monitoring of CrSO2 and brain electrical activity was conducted using near-infrared spectroscopy (NIRS) and aEEG throughout the ECMO treatment. We collected and analyzed related clinical data.ResultsAmong the 11 survivors, 5 were categorized as the normal group (N group) and 6 as the abnormal group (AN group) based on post-ECMO brain MRI outcomes. The N group exhibited shorter time percentage of significant CrSO2 reduction (> 25% from baseline or absolute value < 40%), better fractional tissue oxygen extraction (FTOE) rates, and more stable mean percentage changes in CrSO2 compared to the AN group. Neonates in the N group predominantly showed mildly abnormal aEEG readings, with one patient displaying disrupted sleep-wake cycles. This particular patient also had more significant CrSO2 reduction and poorer FTOE compared to others in the N group. Additionally, the Test of Infant Motor Performance (TIMP) scores indicated hypoevolutism in this patient before discharge, while others in the N group had normal TIMP scores. In the AN group, 4 exhibited moderate and 2 severe aEEG abnormalities; 5 had hypoevolutism TIMP scores, and 1 with moderate aEEG abnormalities maintained a normal TIMP score, exhibiting lesser CrSO2 reduction and improved FTOE.ConclusionCrSO2 and aEEG monitoring show potential as routine assessments for neurological outcomes during neonatal ECMO. In our cohort, a tendency was observed where neonates with greater reductions in CrSO2 and more severe aEEG abnormalities experienced poorer neurological outcomes.

Evaluation of Totarol for Promoting Open Wound Healing in Dogs.

This study investigates the susceptibility of common pathogens to totarol and assesses its clinical effectiveness in promoting wound healing in client-owned dogs with open wounds. Twenty-three client-owned dogs with open wounds were divided into two groups: (1) the treatment group (T-group) and (2) the control group (C-group). Clinical samples were collected from the wounds for the bacterial identification and determination of the minimum inhibitory concentrations (MICs) of totarol. In the T-group, wounds were treated with standard wound care together with the application at a dosage of 0.3 mL (two sprays) of commercial totarol product per 25 cm2 of the wound area. The C-group received only standard wound care. This in vitro study found that totarol exhibited antimicrobial activity against both standard pathogens and clinical wound pathogens. The MIC values of totarol dissolved in absolute ethyl alcohol were 4 µg/mL for Gram-positive pathogens and ranged from 256 to 512 µg/mL for Gram-negative pathogens. However, the MIC values of the commercial totarol product ranged from 512 to 1024 for both Gram-positive and Gram-negative pathogens. Clinically, the use of a commercial totarol product as an adjunctive therapy significantly improved wound healing, as indicated by a greater percentage of wound area reduction (p < 0.05). From day 2 to day 7 of the treatment, the percentage of wound area reduction differed significantly between the T-group and the C-group. At the end of the study, the average percentage of wound area reduction was 69.18% ± 18.12 and 41.50% ± 20.23 in the T-group and C-group, respectively. The finding of this study illustrates the antimicrobial properties of totarol and its product against prevalent wound pathogens. These results suggest the potential of totarol as an adjunctive option for canine wound care.

A novel extended social force model for studying the impact of the heterogeneity of pedestrian physical fitness on emergency evacuation efficiency

Emergencies in public places, particularly confined crowded areas, will disrupt the stability of dense crowds and consequently lead to accidents. To promote public emergency safety, there is a pressing need for efficient modeling methods to investigate the evacuation mechanism in these places and improve the social public safety. This study proposes a Physical Fitness Heterogeneity based Social Force Model (PFH-SFM) that takes into account the heterogeneous desired evacuation velocity caused by the heterogeneity of pedestrian physical fitness, by means of developing the normalized desired velocity ratio. Then, we use PFH-SFM to investigate the relationships between the escape rate and the desired velocity, and between the evacuation duration and the desired velocity in terms of various group sizes with heterogeneous physical fitness, the relationship between the percentage of reduction in evacuation duration and desired velocity when including weak pedestrians, the pedestrian distribution in the evacuation process, the relationship between the total evacuation duration and the desired velocity in terms of various proportions of weak pedestrians and the relationship between the evacuation duration and the desired velocity in terms of various normalized starting and ending velocity ratios by considering various group sizes, respectively. The findings of this study show that the existence of a certain small proportion of pedestrians with weak physical fitness can promote global evacuation dynamics, especially in the case of high crowded density, and can reduce evacuation duration by up to 20% in our experiments. Additionally, when the percentage of pedestrians with weak physical fitness is relatively high, they tend to have a detrimental effect on the evacuation efficiency. Furthermore, there exists a moderate normalized desired starting velocity ratio that maximizes the overall evacuation efficiency; on the other hand, the lower the normalized desired ending velocity ratio is, the more efficient the evacuation is. To the best of the authors’ knowledge, this study is the first time to introduce the concepts of normalized desired starting and ending velocity ratios and innovatively analyzes the impact of the continuously changing desired velocity of pedestrians on the evacuation efficiency in multi-exit scenarios. The results offer valuable insights for relevant stakeholders to formulate effective evacuation plans, so as to enhance urban emergency capacity and minimize social and economic losses.

Intralesional immunotherapy of cutaneous warts using tuberculin purified protein derivative and vitamin D3 – A randomized comparative study

Objectives: Numerous studies have been conducted on the clinical efficacy of immunotherapeutic agents in the treatment of cutaneous warts showing variable results. The present study aimed to compare the clinical efficacy and safety of intralesional tuberculin purified protein derivative (PPD) and Vitamin D3 therapy in recurrent and recalcitrant extra-genital cutaneous warts. Material and Methods: This study was conducted as a prospective, randomized, comparative, and single-blind study. A total of 104 patients were randomly distributed into two treatment groups: Group A (Tuberculin PPD, n = 53) and Group B (Vitamin D3, n = 51). Each patient in Group A received an intralesional injection of 0.1 mL tuberculin PPD (5 Tuberculin Units), while each patient in Group B received an intralesional injection of 0.2 mL Vitamin D3 (Cholecalciferol containing 120,000 IU). The injections were given at the initial visit (week 0) and after every 2 weeks for a maximum of four sessions (weeks 2, 4, and 6). The largest wart was selected for intralesional therapy. The categorization of clinical response was done based on the percent reduction in the size of warts into complete (appearance of normal skin), marked (&gt;50% reduction), moderate (&lt;50% reduction), and inadequate (no change in warts) responses. Adverse effects (if any) were recorded during each patient visit. The final response was evaluated at 6 months follow-up from the last treatment session. Results: Regarding the response of patients to tuberculin PPD therapy, out of a total of 53 patients, 40 (75.5%) showed a complete response. Regarding the response of patients to Vitamin D3 therapy, out of a total of 51 patients, 36 (70.6%) showed a complete response. However, the difference in the response to the treatment between the two groups was statistically insignificant (P = 0.402). Conclusion: Both intralesional tuberculin PPD and Vitamin D3 are effective and safe in the treatment of all recurrent and recalcitrant extra-genital cutaneous warts.

Preventive effects of dill oil on potassium bromated-induced oxidative DNA damage in garlic root tips

In this study, the potential antimutagenic/cytoprotective effect of the oil extract (2.5µg/ml) from Anethum graveolens L. (Dill) on oxidative DNA damage was tested. The experiments were carried out to inhibit mutagenicity induced by potassium bromated (KBrO3-9g/l) in Allium assay using mitotic activities and nuclear DNA contents. Result showed a clear reduction in radical length in all KBrO3-treated groups compared to control plants. Mitotic activity, measured by mitotic index (MI) and mitotic stages, were significantly decreased in meristematic cells after KBrO3 application, The results showed that mitotic index (MI) was decreased to reach about 0.8 at 24 hrs compared with 23.9% in untreated plants. The analysis of potential cyto and genoprotective of dill extract on nuclear DNA contents showed a statistically significant increase in the nuclear DNA content compared to KBrO3-treated roots was observed. Clearly, dill oil showed highly performance in protecting the mitotic cells against mutagenic KBrO3 effects by increasing the MI and decreasing the abnormal chromosomes. Also, the percentage of damage reduction was observed in the pre- (28.9, 57.9 and 46.4 %), simultaneous (53.0, 70.6 and 35.7 %) and post- (37.3, 61.8 and 50 %) treatment. The results of the qualitative study showed that this dill extracts were rich in chemical compounds belonging to several phytochemical classes. GC-MS analysis detected 29 chemical compounds with different concentrations. The predominant ones were Octadecanoic acid (31.75%) and 2-pentanone, 4-hydroxy-4-methyl (16.77). So that these experiments will help to understand and uncover the mechanism of action dill oil against the mutagenic effects of KBrO3 (i.e whether they have a prophylactic or treatment activity).

Enhancing Building Stability and Seismic Resilience with Water-Added Tuned Mass Dampers

These days, the construction industry is increasingly producing buildings with extremely low damping values. Under structural vibrations caused by storms and earthquakes, structures can collapse easily. There are now several methods for reducing structural vibrations, and one of the methods currently employed is the Tuned Mass Damper (TMD). Research is being conducted to determine its performance and importance. The entire damper was tuned for various constructions. An eight-story model specifically designed for the structure was used in this study to observe the structure's response with and without TMD during shaking table experiments. Compared to passive control devices (PTMDs), Active Tuned Mass Dampers (ATMDs) are more efficient as they are active control devices powered externally. By maintaining the structure's frequency, damping, and stiffness constant, other variables such as the percentage reduction in structural capacity can effectively control structure vibrations. The findings and observations from TMD studies can be used to address challenges in earthquake structural control considering current technological limitations and energy demands. The results illustrate significant improvements with damping: the damped structure experienced a 21% increase in acceleration, a 17% increase in velocity, and a 79% reduction in displacement compared to the un damped structure. These findings underscore the effectiveness of damping in mitigating earthquake-induced vibrations.

A Toolpath Generator Based on Signed Distance Fields and Clustering Algorithms for Optimized Additive Manufacturing

Additive manufacturing (AM) methods have been gaining momentum because they provide vast design and fabrication possibilities, increasing the accessibility of state-of-the-art hardware through recent developments in user-friendly computer-aided drawing/engineering/manufacturing (CAD/CAE/CAM) tools. However, in comparison to the conventional manufacturing methods, AM processes have some disadvantages, including the machining precision and fabrication process times. The first issue has been mostly resolved through the recent advances in manufacturing hardware, sensors, and controller systems. However, the latter has been widely investigated by researchers with different toolpath planning perspectives. As a contribution to these investigations, the present study proposes a toolpath planning method for AM, which aims to provide highly continuous yet distance-optimized solutions. The approach is based on the utilization of the signed distance field (SDF), clustering, and minimization of toolpath distances among cluster centroids. The method was tested on various geometries with simple closed curves to complex geometries with holes, which provides effective toolpaths, e.g., with relative distance reduction percentages up to 16.5% in comparison to conventional rectilinear infill patterns.

Design Optimization and Experimentation of Triple-Head Gradually Reducing Spiral Precision Fertilizer Apparatus

In order to solve the problems of existing spiral fertilizer apparatuses, such as the variation in cavity filling rate with rotational speed, fluctuation of fertilizer discharge flow, and inability to discharge fertilizer precisely, a triple-head gradually reducing spiral fertilizer apparatus is designed, which gradually compresses fertilizer particles through the triple-head reducing fertilizer spiral structure to achieve complete cavity filling and uniform fertilizer discharge. The main factors that affect the particle motion state and the structural size of the spiral fertilizer through theoretical analysis are determined, and its theoretical fertilizer discharge amount and rotational speed are calculated. Using EDEM (Discrete Element Method Software 2022) to establish a simulation model of a single-head gradually reducing fertilizer apparatus, the spiral lead reduction percentage x1, spiral diameter reduction percentage x2, and rotational speed x3 are determined as experimental factors, and the filling rate μ and spiral torque Yaverage are used as experimental indicators to conduct a simulation study on the secondary universal rotation combination design experiment. The results show that when the rotational speed is 95 r/min, the spiral lead reduction percentage is 60.00~73.21%, the spiral diameter reduction percentage is 86.55~97.05%, the filling rate μ is greater than 95%, and the spiral torque Yaverage is less than 16 N·m. In order to further improve the uniformity of fertilizer discharge and ensure the controllable accuracy of fertilizer discharge, comparative verification experiments are conducted on single-, double-, and triple-head gradually reducing spiral fertilizer discharge devices and ordinary spiral fertilizer discharge devices. The results show that the precision of the gradually reducing spiral fertilizer apparatus is better than that of the ordinary spiral fertilizer apparatus. Moreover, it is determined that the three-head style performed best. The triple-head gradually reducing spiral fertilizer apparatus is also validated by randomly adjusting six rotational speeds. The experiment results show that the average deviation of the fertilizer discharge flow rate of the fertilizer apparatus from the preset value is 3.16%. The two have a minor deviation, and the fertilizer precision is high. Precise control of the amount of fertilizer discharged can be achieved by adjusting the rotational speed, and the research can provide a specific reference for the improved design and precise control of the spiral fertilizer apparatus.

Smells Like Anthelmintic Resistance-Gastrointestinal Prevalence, Burden and Diversity in Dogs from Portugal.

Anthelmintic resistance has been documented worldwide, but few cases have been reported in dogs. Shelter dogs are a great opportunity to study intestinal helminths and assess their potential resistance to anthelmintic compounds. With these two goals in mind, 361 faecal samples were collected from dogs in 18 municipalities in Portugal, from 19 shelters and 11 private tutors. These samples were analysed using the Mini-FLOTAC before and 13 days after deworming. The percentage of faecal egg count reduction was calculated. Parasitic forms were identified in 22.4% of the samples collected: Trichuris vulpis (10.5%), Toxocara canis (8.0%), members of the family Ancylostomatidae (6.4%), Toxascaris leonina (0.8%), Dipylidium caninum (0.6%) and members of the family Taeniidae (0.3%). The first three nematode parasites showed the highest intensity of infection (2900, 1325, and 1265 eggs per gram, respectively). In the second faecal collection, parasites were present in 20.8% of the samples. The anthelmintics febendazole + pyrantel embonate + praziquantel and praziquantel + fenbendazole were ineffective for T. vulpis and members of the family Ancylostomatidae in 16.2% and 6.9% of the samples, respectively. The parasites identified are all potentially zoonotic. This study is the first to suggest a potential resistance of T. vulpis to anthelmintics.

Maxillomandibular Advancement for Obstructive Sleep Apnea in Patients With Obesity: A Meta-Analysis.

To systematically review polysomnographic and cephalometric data in obstructive sleep apnea (OSA) patients with obesity (body mass index [BMI] ≥30 kg/m2) treated with maxillomandibular advancement (MMA). Scopus, PubMed, CINAHL, and The COCHRANE Library. A search was performed from inception until April 3, 2024, in each database. A total of 14 studies (143 subjects) were included. The mean age was 44.3 years (range: 17-69), 80.2% males (95% CI: 72.5-86.5), mean BMI of 35.3 (95% CI: 33.1-37.5), and mean duration to follow-up post-MMA was 13.7 months (95% CI: 10.1-17.3). All objective outcomes improved significantly; overall, apnea-hypopnea index (AHI) decreased by -57.3 ([95% CI: -71.5 to -43.2], p < 0.0001) lowest oxygen saturation (LSAT) increased by 14.1% ([95% CI: 9.9 to 18.3], p < 0.0001), and Epworth Sleepiness Scale (ESS) decreased by -9.4 ([95% CI: -13.5 to -5.2], p < 0.0001). Surgical cure was 39.2% (95% CI: 20.3-60.0), and surgical success was 85.6% (95% CI: 77.8-91.5). Comparing percent reduction in class 3 obesity (-92.9%) as compared to class 1 (-85.5%) and class 2 (-83.6%) exhibited a significant difference (1 vs 3 p = 0.0012, 2 vs 3 p = 0.015). Our findings suggest that MMA significantly improves subjective and objective outcomes in OSA amongst patients with obesity with results comparable to the overall population. Success rates remained above 80% in studies with the highest mean BMI. In addition, patients with class 3 obesity yielded a significantly increased benefit based on percent reduction in AHI compared with class 1 and 2. 1 Laryngoscope, 2024.

Electroacupuncture versus solifenacin succinate for female overactive bladder: study protocol for a multicentre, randomised, controlled, double-dummy, non-inferiority trial

IntroductionOveractive bladder (OAB) affects approximately 500 million people worldwide, with a higher prevalence in women than in men, significantly impacting the quality of life of female patients. Treatment options for...

Removal of pollutants from pharmaceutical wastewater through electrofenton membrane bioreactor (EFMBR)

The treatment of effluent with diversified membrane technology related processes is not satisfying due to its own disadvantages and as a result the standard limits prescribed could not be met. This research work mainly focuses on the elimination of impediments associated with membrane bioreactors (MBRs). The irreversible fouling was found to greatly reduce by the addition of electrochemical pre-treatment processes with MBR. Chemical Oxygen Demand (COD) and Total Dissolved Solids (TDS) are the majorly considered water parameters and they are evaluated in the case of integrated electro-fenton membrane bioreactor (EFMBR), which is a hybrid technology comprising of electro-fenton pretreatment process with ozonation and MBR technology. This is proved to be highly effective with an excellent reduction percentage of 92 % COD and 50 % TDS respectively. Gas chromatography (GC) analysis of the pharmaceutical effluent upon treatment in EFMBR justified the quantitative reduction of pharmaceutical compounds. The results obtained on experimentation of EFMBR clearly indicated that there is a little internal and external fouling which is significantly proved through Hermia modelling and Scanning Electron Microscopy (SEM) analysis. The most eminent result obtained in this study were the efficacy of EFMBR to operate without the issue of filamentous bulking and it supported that electro-fenton could have played the major role for the achievement of eradicating fouling in EFMBR. The results obtained from this process gives an insight to researchers to overcome the irreversible fouling in industrial and municipal water treatment. The outcome of this study shows the insightful way employing this technology in water treatment industries could highly reduce the environmental problems.