Mean Weight Reduction Research Articles

The intravenous fat tolerance test in subjects with massive obesity. A study before and after jejuno-ileal shunt operation.

Abstract. The i.v. fat tolerance test (IVFTT), in which the elimination rate of the fat emulsion Intralipid® is determined, has been performed in 60 patients with massive obesity. These patients were compared with a control group of matched subjects of normal weight with the same plasma TG concentrations. The hyperbolic correlations which were found between the plasma TG concentration and the IVFTT value did not differ between the two groups. The IVFTT value was correlated rather to the plasma TG value than to total body weight. The IVFTT values were higher in women of both groups. Twenty‐three obese patients were studied with IVFTT before and after a jejuno‐ileal bypass operation. Concomitant with a mean weight reduction from 129 to 104 kg, plasma TG was significantly reduced from 1.92 to 1.40 mmol/l. The IVFTT value rose significantly from 3.99 to 5.83 %/ min. However in the individual cases the pattern was highly variable, as some patients lost weight considerably without major effects on the IVFTT value, whereas others had a marked fall of plasma TG and rise of IVFTT value concomitant with a very moderate weight loss. The results suggest that the reduced IVFTT values in massive obesity are of the same order as seen in primary hyper‐lipidaemia and that the removal sites for the Intralipid® emulsion are not proportionate to the amount of adipose tissue. Other factors than weight loss, such as changes of blood flow in the splanchnic region, could possibly account for the increased IVFTT values after jejuno‐ileal bypass operations.

Liquid Feeding of Glasshouse Tomatoes; The Effects of Potassium Concentration on Fruit Quality and Yield

SummaryThe effect of four concentrations of nutrient solution containing potassium nitrate and ammonium sulphate (K2O/N=1.75) upon the yield and grading of glasshouse tomatoes has been studied for three seasons. The effect of the treatments on the chemical composition of the fruit, with particular reference to acidity, sugars and total solids, has also been studied for one season. Apart from a base dressing at the start of the first season, all the nitrogen and potash was applied in solution by hose watering.The proportion of uniformly coloured fruit increased significantly with increasing nutrient concentration, accompanied by some reduction in total crop yield and mean weight per fruit.The percentage of dry matter in the fruit, and the titratable acidity and total solids content of the expressed juices, rose with increasing concentration of the nutrient solution up to 225 p.p.m. nitrogen and 394 p.p.m. potash, the latter corresponding to 16-18 cwt. of potash (K2O) per acre annually.Consideration of the ...

INCREASED PITUITARY GONADOTROPHIN ACTIVITY AFTER DEGENERATION OF SEMINIFEROUS TUBULES PRODUCED BY NITROFURAZONE

The effects of nitrofurazone on the testis and seminal vesicles of normal and cortisone-maintained hypophysectomized mice was studied. The antiandrogenic effect of nitrofurazone was seen in mice receiving .04% nitrofurazone by the 35% reduction in mean weight of the seminal vesicle although there was no change in body or testicular weight. With doses of .15-.3% there was a 59% decrease in weight of the testis although there was hypertrophy and hyperplasia of the interstitial cells. In these animals seminal vesicles were normal or enlarged. When the mice were overcome by the cytotoxic effects of the .6% nitrofurazone and died 6-9 days after administration the testis and seminal vesicle both showed atrophy. Hypophysectomized mice on .04% nitrofurazone did not differ from the controls. Mice on .15-.2% nitrofurazone showed greater atrophy. It is suggested that the secondary androgenic effect is due to release from a pituitary-inhibiting factor normally liberated by the germinal cells.