Irregular Reduction Research Articles

Analysis of foreign practice of forming indicators for auditing the efficiency of government agencies' activities

The article highlights the topical problem of analysing and managing the effectiveness of public bodies' performance on the basis of international experience. The introduction argues the significance of effective public administration to ensure socio-economic stability and security of national resources. The aim of the study is to adapt foreign methodologies and practices to optimise the use of public funds in Kazakhstan. The literature review presents performance audit as a result of the development of result-oriented budgeting and a factor contributing to the efficiency of public bodies. Key aspects are considered: the role of publicity and transparency in governance, the effectiveness of public audit bodies and the reduction of irregularities in budget spending. Special attention is paid to international standards and practical experience of performance audit, emphasising adaptation to the specifics of Kazakhstani legal regulation and national traditions. The article analyses the challenges faced by Kazakhstani authorities in implementing a system of performance audit indicators, including the choice and methodological justification of indicators, as well as their role in assessing the performance of state structures.

Corneal Epithelial Wavefront Error as a Novel Diagnostic Marker for Epithelial Basement Membrane Dystrophy.

Synopsis: Corneal epithelial wavefront error and epithelial thickness variance qualify as highly sensitive and specific biomarkers for epithelial basement membrane dystrophy (EBMD). The biomarkers show a normalization after treatment of EBMD with phototherapeutic keratectomy. Purpose: To gauge the diagnostic value of epithelial basement membrane dystrophy (EBMD), a novel spectral-domain optical coherence tomography (SD-OCT)-based imaging modality for simultaneous morphological (thickness profile) and refractive (optical wavefront) assessment of the corneal epithelial layer in one of the most common but often underdiagnosed corneal dystrophies. Methods: In this prospective observational study, a total of 32 eyes of 32 patients diagnosed with EBMD and 32 eyes of 32 healthy control subjects were examined with high-resolution anterior segment SD-OCT (MS-39; CSO, Florence, Italy). Various epithelial thickness and epithelial wavefront-derived terms were compared between groups and receiver operating characteristic (ROC) curves were computed to analyze the diagnostic capacity of the respective parameters. A total of 17 of 32 EBMD patients underwent treatment with phototherapeutic keratectomy (PTK) and were followed up for 3 months. Results: Epithelial thickness variance (60.4 ± 56.7 µm versus 7.6 ± 6.1 µm) and interquartile range (11.0 ± 6.9 versus 3.3 ± 1.9 µm) were markedly elevated in EBMD patients as compared with healthy controls (both with p < 0.001). Epithelial wavefront analysis showed a highly statistically significant excess in all examined aberration terms in EBMD patients (all with p < 0.001). Significantly greater areas under the curve (AUCs) were yielded by the epithelial wavefront-derived parameters (e.g., total epithelial wavefront error: AUC = 0.966; 95% confidence interval (CI) 0.932-1) than by the epithelial thickness-derived parameters (e.g., variance: AUC = 0.919; 95% CI 0.848-0.990). Conclusions: Corneal epithelial wavefront aberrometry proved valuable as an objective biomarker for EBMD, with high sensitivity and specificity. PTK resulted in a reduction of morphological and refractive epithelial irregularities in EBMD.

Microwave-assisted green synthesis of silver nanoparticles using Cynoglossum furcatum extract: biomedical evaluation against A431 skin cancer cell line

ABSTRACT The present study was carried out to synthesize silver nanoparticles (AgNPs) from an aqueous leaf extract of Cynoglossum furcatum, which functioned as a capping agent and reducing agent. The synthesized AgNPs have been revealed using a variety of microscopy techniques. The spherical dimension is exploited by electron microscopies, which have an average nanoparticle size of 33 nm. A topographical photograph of Cynoglossum furcatum AgNPs was obtained using atomic force microscopy, demonstrating the reduction of surface irregularity. The MTT assay was employed to evaluate the effect of the plant extract and the AgNPs on the Vero, 3T3 L1, and A431 cell lines. The agar disk diffusion was employed to evaluate the antibacterial efficacy with E.coli, S.typhi, S.aureus, and E.faecalis, as well as the antifungal efficacy against A.niger, C.albicans, A.flavus, and A.fumigates, which exhibited substantial antimicrobial activity.

Supraperiosteal technique protocol for forehead filling with a mixture of calcium hydroxyapatite and hyaluronic acid: Double-blind, randomized controlled clinical trial.

The current study aims to investigate the safety and efficacy of using calcium hydroxyapatite (CaHA) versus CaHA associated with hyaluronic acid (HA) for forehead volume replacement and contour restoration without forehead irregularities. This interventional study involved 132 participants in a two-arm, parallel, double-blind trial for forehead treatment using the supraperiosteal technique. Group A received CaHA, and Group B received a combination of CaHA and HA as filler materials. Follow-up assessments occurred at 30 and 180 days, incorporating the 5-point Global Aesthetic Improvement Scale (GAIS) and photographic analysis for forehead volume replacement, contour restoration, and without forehead irregularities. Safety assessments included monitoring adverse events, particularly nodules. The study included all 132 enrolled patients who completed the trial. Applying CaHA in combination with HA resulted in a statistically significant improvement in both GAIS scale scores and the reduction of forehead irregularities. The total incidence of nodules was 3.7%. Group A had four times more occurrences of nodules than Group B. Furthermore, Group B exhibited lower rates of forehead irregularities following the treatment compared to Group A. The supraperiosteal application of CaHA and HA for forehead treatment demonstrates superior efficacy in addressing signs of aging compared to the isolated use of CaHA.

Ultrathin Carbon Textures Produced on Machined Surfaces in an Integrated Finishing Process Using Microabrasive Films.

This study presents research into the unique method of depositing carbon layers onto processed surfaces, during finishing with abrasive films, on a global basis. The authors of this article are holders of the patent for this method. What makes this technology outstanding is that it integrates processes, whereby micro-finishing and the deposition of a carbon layer onto freshly exposed surface fragments is achieved simultaneously, in a single process. Among the main advantages accruable from this process is the reduction of surface irregularities, while the deposition of a carbon layer is achieved simultaneously. Ultrathin graphite layers can be widely used in conditions where other methods of reducing the coefficient of friction are not possible, such as in regard to micromechanisms. This article illustrates the application of carbon coating, end on, on a surface processed with abrasive film, containing intergranular spaces, saturated with graphite. Thin carbon layers were obtained on two substrates that did not contain carbon in their initial composition: soda-lime glass and a tin-bronze alloy. It was performed through microscopic examinations of the produced surface, roughness analyses of these surfaces, and analysis of the chemical compositions determined by two methods, namely EDS and GDOES, proving the existence of the coatings. The aim of this paper is to prove the possibility and efficiency of using graphite-impregnated lapping films in the deposition process of carbon films, with improved surface smoothness, durability, and wear resistance. The produced coatings will be tested in regard to their operational properties in further research. The authors underline the potential of this method to revolutionize surface treatment processes, due to the significant advantages it offers across various industries.

Enhancing smoke management in underground parking areas using jet fan systems with a focus on dead-end areas

This study delves into the utilization of jet fans in underground parking structures for smoke management during fires, with a specific focus on enhancing smoke control near critical areas adjacent to dead-end sections through innovative jet fan designs. Through the analysis of airflow patterns and computational fluid dynamic simulations, the research aims to effectively contain smoke and prevent its dispersion to unaffected zones. Findings underscore the significance of parking layout designs in ventilation strategies and soot dispersion rates. Altering the downward orientation of the jet fan outlet results in a notable portion of smoke being confined within the parking facility. Additionally, widening the jet fan outlet, as proposed in the design, can enhance smoke evacuation in all directions. Two hazard detection scenarios were executed within the parking structure following the British standard (BS), with one scenario simulated as a fire ignition source. The chosen scenario considers all escape routes and evacuation procedures within the underground parking area based on architectural specifications. By employing OpenFOAM software with the buoyantBoussinesqPimpleFOAM solver, the study assesses the efficacy of this approach, achieving a reduction in airflow irregularities of over 30%. It also provides valuable insights for designers to refine their comprehension of jet fan design, recommending tailored designs for specific zones. This research offers practical guidance for designers to optimize jet fan configurations for effective smoke control in underground parking facilities.

Mechanism of cross-level settlements and void accumulation of wide and conventional sleepers in railway ballast

AbstractThe cross-level and twist irregularities are the most dangerous irregularity types that could cause wheel unloading with the risk of derailments and additional maintenance expenses. However, the mechanism of the irregularities initiation and development is unclear. The motivation of the present study was the previous experimental studies on the application of wide sleepers in the ballasted track. The long-term track geometry measurements with wide sleepers show an enormous reduction of the vertical longitudinal irregularities compared to the conventional track. However, wide sleepers had higher twist and cross-section level irregularities. The present paper aims to explain the phenomenon by discrete element method (DEM) modeling the development process of sleeper inhomogeneous support at cross-level depending on the sleeper form. The DEM simulations show that the maximal settlement intensity is up to 3.5 times lower for a wide sleeper in comparison with the conventional one. Nevertheless, the cross-level differential settlements are almost the same for both sleepers. The particle loading distribution after all loading cycles is concentrated on the smaller area, up to the half sleeper length, with fully unloaded zones under sleeper ends. Ballast flow limitation under the central part of the sleeper could improve the resilience of wide sleepers to the development of cross-level irregularities. The mechanism of initiation of the cross-level irregularity is proposed, which assumes the loss of sleeper support under sleeper ends. The further growth of inhomogeneous settlements along the sleeper is assumed as a result of the interaction of two processes: ballast flow due to dynamic impact during void closing and on the other side high pressure due to the concentration of the pressure under the middle part of the sleeper. The DEM simulation results support the assumption of the mechanism and agree with the experimental studies.

When words coalesce II

Abstract This article is a sequel to my contribution entitled “When words coalesce: chunking and morphophonemic extension” in the volume The Indo-European verb (ed. H. Craig Melchert, 2012: 87–104), and intends to document cases of preverb incorporation for Proto-Indo-European (PIE). Although preverbs occurred as free morphemes with finite verbs in PIE, they could also, under conditions to be specified, undergo a change of their morphemic status from free to bound. I discuss a number of such cases and the conditions under which preverbs could undergo destressing, phonologically regular or irregular reduction, and ultimately fuse with following verbal root morphemes.

Combination treatment of recombinant growth differentiation factor-9 and Cetrorelix improves gestational origin of the polycystic ovarian syndrome in female rats

AimsPolycystic ovary syndrome (PCOS) is a hyper-androgenic endocrinopathy prevalent in premenopausal women with no cure available. The current study aimed to investigate the therapeutic effect of recombinant GDF-9 and Cetrorelix on the gestational origin of dehydroepiandrosterone (DHEA) induced PCOS in postnatal pups' delivered to rat dams. Main methodsThe body weight measurement, blood and serum analysis for glucose tolerance, lipid profile, liver enzymes, sex hormones (Testosterone, Estradiol, and Progesterone), estrus cyclicity assessment, histological staining of ovary and liver, molecular markers expressions of pro-inflammatory by qRT-PCR and immuno-histochemistry technique for folliculogenesis genes and histological staining studies of liver and ovary were done. Key findingsThe combinational treatment was found to normalize the biochemical parameters and reduction in the estrus irregularity by altering the sex hormones as well as the glucose metabolism and insulin resistance via HOMA-IR value. Further, molecular markers expression confirmed the pro-inflammatory (IL-1β, TNF-α, and IL-6) and folliculogenesis (GDF-9, BMPR2, and TGF-βR1) genes associated with PCOS were improved by combinational therapy. SignificanceIn conclusion, rGDF-9 could be a potential therapeutic agent in combination with Cetrorelix as a better treatment regime for metabolic and reproductive phenotypes in PCOS. However, the effect of rGDF-9 on infertility-associated phenotypes in PCOS needs further evaluation.

Neutron screen method for axial uniformity in silicon ingots for neutron transmutation doping at WWR-K reactor

In 2017, Institute of Nuclear Physics and Chiyoda Technol Corporation signed agreement on cooperation in research and development of technology for neutron-transmutation doping of large-sized silicon with a diameter of more than 6 in. and a height of up to 500 mm for the WWR-K reactor.The goal of the study is to reduce an irregularity in the electrical resistivity over the volume of the silicon ingot to (3–4)%. In view of reduction of the height irregularity factor, thermal neutron-absorbing materials are used, whereas an electric motor, which provides rotation of silicon ingot around its axis, is used to reduce the radial irregularity. The object of investigation is an aluminum block, which is a model of silicon ingot.This work presents the obtained at the critical facility results of the study the application of the screen method to the reduction of the height irregularity for doping in large-size silicon ingots.

Process Optimization for Up-Facing Surface Finish of AlSi10Mg Alloy Produced by Laser Powder Bed Fusion

This work investigates the effects of various processing parameters (laser power, scanning speed, hatch distance and beam offset) on the resultant inclined up-facing surface roughness of AlSi10Mg alloys produced by laser powder bed fusion (LPBF). A two-step approach, orthogonal test followed by the Doehlert matrix design (DMD) test is used to efficiently optimize the up-facing surface and contour parameters. The former method aims to determine the significance of variables while the latter one facilitates a rapid optimization. The results show that the interaction and interdependency among the parameters are of great significance to the obtainable surface roughness. Using a rational design of experiments, the optimized up-facing surface roughness of Ra of 5.4 μm is achieved. This is attributed to the elimination of the laser partition track and the reduction in irregularities at the edges of the parts. This work demonstrates an effective approach of experimental processing parameter optimization to improve the surface finish of LPBF parts.

Mitigation of Design Issues in Development of Anatomical Models Using Rapid Prototyping

Literature indicates rapid prototyping (RP) application has become more widespread in design and development of human anatomy models. Practitioners are facing challenges in deployment of RP tools for development of cost-effective medical models, because there are no proven decision support systems in the selection of parameters such as speed, accuracy, materials, and customisation of commercial software. This study aims at alleviating some of these issues by exploring the use of a Genetic Algorithm (GA) approach combined with computer-aided design (CAD) and fused deposition modeling (FDM) techniques. Experiments were conducted using response surface methodology (RSM) to facilitate the optimisation process with build time and model material volume as responses. The validation of the study has been performed with a patella model and the results verified the effectiveness of the proposed RSM-GA approach in the design and development of the anatomical model. The results showed a 27% savings on model material compared to a non-refined model and was deemed satisfactory for practical use as there was a reduction in irregularities from CT data. The study also reveals that the parameter hollow has the largest effect on the responses, followed by the smooth parameter and then the wrap parameter.

Micro/nanostructured bioactive titanium implant surface with sol-gel silicate glass nanoparticles

Andrew M. Shenoda, BDS/Maged A. Gadallah, MSc/Rahaf M. Darwish, MSc/Mona S. Saad, PhD/Mona K. Marei, PhD: Purpose: To develop a surface coating of sol-gel 70S30C bioactive glass (BAG) nanoparticles on titanium disks and dental implants and to characterize the results in terms of average surface roughness, adhesion strength, and coating stability upon implant insertion under clinical settings. Materials and Methods: BAG was prepared with the modified sol-gel technique, then milled into nanoparticles. The resultant powder was characterized in terms of phase structure, composition, and particle size. Titanium disks and dental implants were coated with BAG nanoparticles by electrophoretic deposition. Surface characterization of coated implants was conducted. Uncoated vs BAG-coated implants were examined for average surface roughness by a confocal laser scanning microscope. The pull-off test was conducted to measure the adhesion strength of BAG coating to the underlying disks. Coated implants were inserted under clinical settings into artificial and natural bone to measure the amount of coating loss and to evaluate the effect of insertion on coating thickness. Results: BAG nanoparticles had an amorphous structure, with a particle size of < 20 nm in diameter. Electrophoresis resulted in a continuous coating covering the whole implant surface. Microscopic analysis confirmed the porous nanostructure of BAG coating, which formed a homogenous surface with microcracks. BAG coating had a uniform thickness of 35.38 ± 4.67 μm. Average surface roughness was significantly lower for BAG-coated implants, with a reduction of surface irregularities (3.34 ± 0.45 μm for uncoated implants, 1.45 ± 0.23 μm for BAG-coated implants). Adhesion strength of 18.51 ± 3.37 MPa was recorded for BAG coating, and 66.23% ± 10.23% of the coating weight was found to remain on the implant surface after insertion into artificial bone. A reduction in BAG coating thickness occurred only in sites of high friction with bone after implant insertion into bovine bone. Conclusion: Coating titanium implants with 70S30C BAG nanoparticles is attainable through electrophoretic deposition and results in a homogenous coating layer with a moderately rough surface, considerable adhesion strength, and high coating stability observed during implant insertion.

Stable lattices in p-adic representations II. Irregularity and entropy

For any irreducible representation of a group in a finite dimensional vector space over a local field K with precompact image and irregular reduction, we show that the class number (the number of stable lattices up to homothety) grows at least exponentially in the base change to an infinite tower of totally ramified extensions of K.More precisely, we find upper and lower bounds for the exponential growth (entropy) in terms of some natural invariants associated with ρ, including the Schur index and the irregularity (defined below).

Pathophysiological Changes in the Enteric Nervous System of Rotenone-Exposed Mice as Early Radiological Markers for Parkinson's Disease.

Parkinson's disease (PD) is known to involve the peripheral nervous system (PNS) and the enteric nervous system (ENS). Functional changes in PNS and ENS appear early in the course of the disease and are responsible for some of the non-motor symptoms observed in PD patients like constipation, that can precede the appearance of motor symptoms by years. Here we analyzed the effect of the pesticide rotenone, a mitochondrial Complex I inhibitor, on the function and neuronal composition of the ENS by measuring intestinal contractility in a tissue bath and by analyzing related protein expression. Our results show that rotenone changes the normal physiological response of the intestine to carbachol, dopamine and electric field stimulation (EFS). Changes in the reaction to EFS seem to be related to the reduction in the cholinergic input but also related to the noradrenergic input, as suggested by the non-adrenergic non-cholinergic (NANC) reaction to the EFS in rotenone-exposed mice. The magnitude and direction of these alterations varies between intestinal regions and exposure times and is associated with an early up-regulation of dopaminergic, cholinergic and adrenergic receptors and an irregular reduction in the amount of enteric neurons in rotenone-exposed mice. The early appearance of these alterations, that start occurring before the substantia nigra is affected in this mouse model, suggests that these alterations could be also observed in patients before the onset of motor symptoms and makes them ideal potential candidates to be used as radiological markers for the detection of Parkinson's disease in its early stages.

Intracorneal Ring Segment Implantation for the Management of Keratoconus in Children.

The short-term safety and efficacy of intracorneal ring segment (ICRS) implantation in keratoconus eyes of children are investigated in this study. A retrospective interventional case series study including a total of 33 keratoconus eyes (age 8 to 17 years) that had undergone ICRS (Keraring segments, Mediphacos) implantation was conducted. Information about visual, refractive, pachymetric, corneal topographic and aberrometric, and corneal endothelial changes during a 3-month follow-up were extracted and analysed. A significant improvement was observed in logMAR corrected distance visual acuity (p = 0.005), combined with a statistically significant reduction in keratometric readings (p < 0.001). A reduction in the magnitude of corneal astigmatism of ≥1 D was observed in 52.8% of eyes. No significant changes were observed in corneal endothelial density (p = 0.317). Significant changes were found in the anterior vertical coma component (p = 0.002) as well as in the spherical aberration of the posterior corneal surface (p = 0.004). Only two relevant complications were described: one corneal microperforation with penetration of the ring segment into the anterior chamber (1 eye, 2.8%), and a case of ring extrusion (1 eye, 2.8%). ICRS implantation in children keratoconus eyes allows a reduction of corneal astigmatism, irregularity, and aberrations, leading to a significant visual improvement.

ПОВЫШЕНИЕ ТОЧНОСТИ РАСЧЕТА ПОЛЯ ТЕМПЕРАТУР ГАЗА НА ВЫХОДЕ ИЗ КАМЕРЫ СГОРАНИЯ ГТД МЕТОДОМ ТРЕХМЕРНОГО КОМПЬЮТЕРНОГО МОДЕЛИРОВАНИЯ

The problem of numerical simulation of the gas flow with the combustion of atomized liquid fuel was solved (the equilibrium combustion model pdf was used along with the partially mixed mixture model) in the annular combustion chamber of a gas turbine engine. Numerical modeling was performed in Ansys Fluent calculation complex. The purpose of the calculations was to simulate the radial and circumferential unevenness of the gas temperature pattern at the outlet of the combustion chamber. As a result of the calculations, it was found that the accuracy of modeling the radial and circumferential unevenness of the gas temperature pattern at the outlet of the combustion chamber is unsatisfactory when using the k–e turbulence model with the initial settings for the Ansys Fluent calculation complex. Moreover, the maximum value of the radial non-uniformity of the gas temperature pattern at the outlet of the combustion chamber exceeded the value obtained in the experiment by 12.61 %, and the maximum value of the circumferential non-uniformity by 12.69 %. To improve the accuracy of modeling the temperature pattern non-uniformity at the outlet of the combustion chamber, a numerical experiment was conducted to study the effect of the degree of turbulent diffusion of gas components on the value of temperature pattern non-uniformity. To reduce the non-uniformity of the temperature pattern at the outlet of the combustion chamber, the degree of turbulent diffusion of gas components was increased with respect to the initial version of the calculation, performed using the k–e model of turbulence with the initial settings for the Ansys Fluent calculation complex, by reducing the turbulent Schmidt number Sc in the turbulence model. For the initial settings of the k–e turbulence model in the Ansys Fluent calculation complex, the turbulent Schmidt number Sc = 0.85. A numerical experiment was performed for the values of Sc = 0.6, Sc = 0.4, and Sc = 0.2. The results of a numerical experiment confirmed the influence of the turbulent Schmidt number Sc on the result of calculating the gas temperature pattern at the outlet of the combustion chamber; as the value of Sc decreases, the level of the circumferential and radial non-uniformities of the gas temperature pattern decreases. However, the degree of reduction of radial and circumferential irregularities with a decrease in Sc is different. Therefore, to ensure high accuracy in calculating both the circumferential and radial non-uniformities of the gas temperature pattern, it was proposed to use a variable value of the turbulent Schmidt number Sc depending on the gas temperature instead of a constant value. The functional dependence of the turbulent Schmidt number Sc on the gas temperature was implemented in the Ansys Fluent calculation complex using the user function (UDF). The results of modeling the gas temperature pattern using the proposed UDF function for the turbulent Schmidt number Sc are in satisfactory agreement with the experimental data for both radial and circumferential non-uniformities of the gas temperature pattern at the outlet of the combustion chamber.

Syllable based Hindi speech recognition

In this paper, one of the acoustic units of speech, the syllable, is used for the development of a continuous Hindi speech recognition system. The syllable is a larger acoustic unit that overcomes the contextual effects and requires fewer training samples in comparison to triphone based and word-based models. Other acoustic units such as phoneme-based suffer from contextual influences, and context-dependent triphones suffer due to the non-availability of triphone patterns with a large memory storage for numerous models. Earlier research works related to Hindi speech recognition were performed using the word, phoneme, and context-dependent models. The authors proposed a syllable based Hindi speech recognition system in this study due to different advantages of syllable units such as longer acoustic units, fast decoding, reducing contextual effects, and reduction of irregularities due to phonemes. The continuous Hindi speech recognition system was developed utilizing syllable based acoustic units. Hindi is widely spoken in India and other parts of the world also. The experiments are performed on Continuous Hindi speech by using a widely known Hidden Markov Model (HMM) with perceptual linear predictive coefficients(PLPs). The research outcomes reveal that by using syllables, the performance of the system was increased by 27% than phoneme and 20% than triphones. Research findings indicate that by selecting an appropriate acoustic unit for Hindi, the performance of the speech recognition system may be improved. Further, the study also provides useful insights to develop a syllable based pronunciation dictionary that may be used in speech recognition, speaker identification, and text to speech conversion systems.

Considerations in Feminization Rhinoplasty.

Rhinoplasty can be a key part of facial feminization for transgender women. Commonly, the required results necessitate significant deprojection of the nose in addition to the reduction of contour irregularities and shaping of the nostrils to a more round appearance. Pitfalls can include disproportion of the tip anatomic subunits, inadvertent creation of epicanthal folds, soft tissue pollybeak creation, and hanging columella among others.

A novel purification machine and fuzzy inference method based hybrid model for wind speed forecasting

As one kind of readily available renewable energy sources, wind is widely used in power generation where wind speed plays an important role. Generally speaking, we need to forecast the wind speed for improving the controllability of wind power generation. However, there exists considerable randomness and instabilities in wind speed data so that it is difficult to obtain accurate forecasting results. In this paper, we propose a novel fuzzy inference method based hybrid model for accurate wind speed forecasting. In this hybrid model, we adopt two strategies to enhance the estimation performance. On one hand, we propose the purification machine which utilize the Irregular Information Reduction Module (IIRM) and the Irrelevant Variable Reduction Module (IVRM) to reduce the randomness and instabilities of the data and to eliminate the variables with zero or negative effect in the wind speed time series. On the other hand, we adopt the developed Single-Input-Rule-Modules based Fuzzy Inference System (SIRM-FIS), the functionally weighted SIRM-FIS (FWSIRM-FIS) to realize the prediction of wind speed. This FWSIRM-FIS utilizes the multi-variable functional weights to dynamically measure the importance of the input variables so that the input-output mapping can be strengthened and more accurate forecasting results can be achieved. Furthermore, detailed experiments and comparisons are given. Experimental results demonstrate that the proposed FWSIRM-FIS and purification machine contributes greatly to deal with the randomness and instability in the wind speed data and yield more accurate forecasting results than those existing excellent forecasting models.