Reduction In FEV1 Research Articles

Association between sedentary behavior and force expiratory volume in 1 second reduction in middle-aged and elderly adults in communities

Objective: To analyze the relationship between sedentary behavior and the force expiratory volume in 1 second (FEV1) reduction in middle-aged and elderly people in communities. Methods: The participants aged ≥40 years were randomly selected from a natural population cohort in Songjiang District, Shanghai, for pulmonary function tests and survey by using international physical activity questionnaire, a generalized additive model was used to analyze the association between sedentary behavior and FEV1 reduction in the study population and different sex-age subgroups. Results: A total of 3 121 study subjects aged ≥40 years were included. The prevalence of FEV1 reduction was 14.8%, which was higher in men than in women. There were 24.8% participants were completely sedentary. The prevalence of FEV1 reduction in women aged <60 years in complete sedentary group was 2.04 (95%CI: 1.11-3.72) times higher than that in non-complete sedentary group. In men aged <60 years, the prevalence of FEV1 reduction increased with daily sedentary time (OR=1.16, 95%CI: 1.04-1.29), and the prevalence of FEV1 reduction was also higher in those with sedentary time >5 hours/day than those with sedentary time ≤5 hours/day (OR=3.02, 95%CI: 1.28-7.16). The sensitivity analysis also found such associations. Conclusions: FEV1 reduction rate in age group <60 years was associated with sedentary behavior. Complete sedentary behavior or absence of moderate to vigorous physical activity played important roles in FEV1 reduction in women, while men were more likely to be affected by increased sedentary time, which had no association with physical activity. Reducing sedentary time to avoid complete sedentary behavior, along with increased physical activity, should be encouraged in middle-aged and elderly adults in communities to improve their pulmonary function.

Short-term effects of the chemical components of fine particulate matter on pulmonary function: A repeated panel study among adolescents

The effects of the chemical components of fine particulate matter (PM2.5) have been drawing attention. However, information regarding the impact of low PM2.5 concentrations is limited. Hence, we aimed to investigate the short-term effects of the chemical components of PM2.5 on pulmonary function and their seasonal differences in healthy adolescents living on an isolated island without major artificial sources of air pollution. A panel study was repeatedly conducted twice a year for one month every spring and fall from October 2014 to November 2016 on an isolated island in the Seto Inland Sea, which has no major artificial sources of air pollution. Daily measurements of peak expiratory flow (PEF) and forced expiratory volume in 1 s (FEV1) were performed in 47 healthy college students, and the concentrations of 35 chemical components of PM2.5 were analyzed every 24 h. Using a mixed-effects model, the relationship between pulmonary function values and concentrations of PM2.5 components was analyzed. Significant associations were observed between several PM2.5 components and decreased pulmonary function. Among the ionic components, sulfate was strongly related to decreases in PEF and FEV1 (−4.20 L/min [95 % confidence interval (CI): −6.40 to −2.00] and − 0.04 L [95 % CI: −0.05 to −0.02] per interquartile range increase, respectively). Among the elemental components, potassium induced the greatest reduction in PEF and FEV1. Therefore, PEF and FEV1 were significantly reduced as the concentrations of several PM2.5 components increased during fall, with minimal changes observed during spring. Several chemical components of PM2.5 were significantly associated with decreased pulmonary function among healthy adolescents. The concentrations of PM2.5 chemical components differed by season, suggesting the occurrence of distinct effects on the respiratory system depending on the type of component.

Short-term exposure to zinc- and copper-containing welding fumes: Effects on pulmonary function in humans

Zinc- and copper-containing welding fumes typically induce a systemic inflammation indicated by increase in C-reactive protein (CRP) levels, also known as welding fume fever. It typically includes symptoms like fever, myalgia or headaches, but only a quarter of patients experience respiratory symptoms, e.g. coughing. This retrospective analysis of data of three studies with either control (filtered air) or zinc- and copper-containing welding fume exposure aims to identify and characterize the effect of the welding fumes on lung function. Spirometry and body plethysmography data of male healthy volunteers were analyzed and comparisons between different timepoints after a 6 h exposure were conducted. For controls no significant changes in spirometry were observed between baseline and 6 h, 24 h and 1 week after exposure. For volunteers exposed to zinc- and copper-containing welding fumes no significant reductions in forced expiratory volume in 1 s (FEV1) and minimal reductions in vital capacity (VC) (52 ml, 0.9%) were detected after 6 h. After 24 h significant reductions in FEV1 (147 ml, 3.2%) and VC (162 ml, 2.9%) could be observed. 1 week after exposure FEV1 was still significantly reduced (102 ml, 2.1%) and airway resistance were increased while no differences in VC were detected. The reduction of FEV1% after 24 week significantly correlated with increases in CRP levels. In conclusion, a single exposure to zinc- and copper-containing welding fumes leads not only to a systemic inflammation but could also induce slight sustained airway constrictions after 24 h and 1 week. The observed slight airway constriction is not caused by immediate effects but possibly inflammatory processes. Although welding fume fever does not necessarily present respiratory symptoms, welders exposed to zinc- and copper-containing welding fumes should be monitored for respiratory symptoms and obstructive ventilation pattern.

The potential role of plasma miR-4301 in PM2.5 exposure-associated lung function reduction

The effect of PM2.5 exposure on lung function reduction has been well-documented, but the underlying mechanism remains unclear. MiR-4301 may be involved in regulating pathways related to lung injury/repairment, and this study aimed to explore the potential role of miR-4301 in PM2.5 exposure-associated lung function reduction. A total of 167 Wuhan community nonsmokers were included in this study. Lung function was measured and personal PM2.5 exposure moving averages were evaluated for each participant. Plasma miRNA was determined by real-time polymerase chain reaction. A generalized linear model was conducted to assess the relationships among personal PM2.5 moving average concentrations, lung function, and plasma miRNA. The mediation effect of miRNA on the association of personal PM2.5 exposure with lung function reduction was estimated. Finally, we performed pathway enrichment analysis to predict the underlying pathways of miRNA in lung function reduction from PM2.5 exposure. We found that each 10 μg/m3 increase in the 7-day personal PM2.5 moving average concentration (Lag0-7) was related to a 46.71 mL, 1.15%, 157.06 mL/s, and 188.13 mL/s reductions in FEV1, FEV1/FVC, PEF, and MMF, respectively. PM2.5 exposure was negatively associated with plasma miR-4301 expression levels in a dose‒response manner. Additionally, each 1% increase in miR-4301 expression level was significantly associated with a 0.36 mL, 0.01%, 1.14 mL/s, and 1.28 mL/s increases in FEV1, FEV1/FVC, MMF, and PEF, respectively. Mediation analysis further revealed that decreased miR-4301 mediated 15.6% and 16.8% of PM2.5 exposure-associated reductions in FEV1/FVC and MMF, respectively. Pathway enrichment analyses suggested that the wingless related-integration site (Wnt) signaling pathway might be one of the pathways regulated by miR-4301 in the reduction of lung function from PM2.5 exposure. In brief, personal PM2.5 exposure was negatively associated with plasma miR-4301 or lung function in a dose‒response manner. Moreover, miR-4301 partially mediated the lung function reduction associated with PM2.5 exposure.

PHARMACOTHERAPY AND LUNG FUNCTION DECLINE IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE : A SYSTEMATIC REVIEW

Chronic obstructive pulmonary disease (COPD) is a long-term condition that affects millions of individuals all over the world and is a major contributor to the rise in hospital admission rates. According to projections made by the World Health Organization (WHO), COPD would become the third greatest cause of mortality worldwide by the year 2020. These patients are also very substantial consumers of the resources made available by the health and social care systems. Because there is now no treatment that can reverse the effects of COPD, patients are responsible for their own healthcare and the management of their condition. There is a correlation between the amount of cigarettes smoked and the degree to which COPD is present. The pathophysiology of COPD is intimately tied to the impact that cigarette smoke has on the lungs. Pharmacological trials that were carried out more than three decades ago with the use of short-acting bronchodilators or inhaled glucocorticoids did not succeed in demonstrating a statistically significant slower rate of FEV1 decline in comparison to the placebo group in their intention-to-treat populations. In light of these equivocal data, the belief that smoking cessation is the only treatment that can delay the course of COPD became widespread. Unfortunately, this pessimism has had a negative impact on how the general public views COPD and has decreased interest in alternative therapeutic techniques. Tiotropium had a greater FEV1 than the placebo, and it also reduced the annual reduction in FEV1 after bronchodilator usage in individuals with COPD who were in the GOLD stage 1 or 2 range. FEV1 drop might be stopped by FF or VI. The patients expressed satisfaction with the treatment, which resulted in fewer exacerbations. It seems like fluticasone furoate or vilanterol could slow down the drop in FEV1 levels.

The impact of telehealth based care on paediatric cystic fibrosis outcomes

In response to the COVID-19 pandemic telehealth utilisation amongst the Cystic Fibrosis (CF) population increased. Our aim was to assess the impact of CF telehealth clinics on CF outcomes. We conducted a retrospective chart review of patients seen in the CF clinic at the Royal Children's Hospital (Victoria, Australia). In this review we compared spirometry, microbiology and anthropometry in the year preceding the pandemic to during the pandemic, and to the first in-person appointment in 2021. 214 patients were included. First in-person FEV1 was median 5.4% below individuals’ best FEV1 in 12 months prior to lockdown and decreased by >10% in 46 (31.9%) patients. There were no significant findings with regards to microbiology or anthropometry. The reduction in FEV1 observed on return to in-person appointments highlights the importance of ongoing improvement of telehealth-based care along with continued face-to-face review for the paediatric CF population.

EFFECT OF BODY MASS INDEX ON PULMONARY FUNCTION OF ELDERLY PEOPLE OF NORTH INDIA

Background: Obesity significantly affects lung function which has been reported among children, adolescents and adult age groups. However, there is limited research on effect of obesity on pulmonary function among elderly age group.Methods:In this study 600 elderly people aged 65 years and above were selected from rural areas of Haryana in whom lung function parameters including force expiratory volume in first second (FEV1),force vital capacity (FVC) and FEV1/FVC were measured. Body mass index (BMI) was estimated and categorised into underweight, normal, overweight and obese categories as per BMI classification of Asian Indians. Mean and standard deviations were calculated and association between lung function parameters and body mass index was determined by one way ANOVA test. Results: Mean age of subjects was 68 ± 5.2 years. Among all the three parameters, highest mean values were observed among subjects with normal body mass index, whereas lowest mean FVC and FEV1/FVC values were observed in underweight category and lowest mean FEV1 values in obese individuals. A statistically significant difference in the mean FEV1 and FEV1/FVC values were observed between various body mass index categories. Conclusion: Body mass index has significant impact on lung function of elderly people depicted by reduction in FEV1 and FEV1/FVC values in obese individuals

Associations between early-life exposure to PM2.5 and reductions in childhood lung function in two North American longitudinal pregnancy cohort studies.

Analyses included children enrolled in two longitudinal birth cohorts in Boston, Massachusetts, and Mexico City. Propensity score matching using the 1:3 nearest neighbor with caliper method was used. Residential PM2.5 exposure was estimated from 2 months before birth to age 6 years using a validated satellite-based spatiotemporal model. Lung function was tested at ages 6-11 years and age, height, race, and sex adjusted z scores were estimated for FEV1, FVC, FEF25-75%, and FEV1/FVC. Using distributed lag nonlinear models, we examined associations between monthly averaged PM2.5 levels and lung function outcomes adjusted for covariates, in unmatched and matched pooled samples. In the matched pooled sample, PM2.5 exposure between postnatal months 35-44 and 35-52 was associated with lower FEV1 and FVC z scores, respectively. A 5 µg/m3 increase in PM2.5 was associated with a reduction in FEV1 z score of 0.13 (95% CI = -0.26, -0.01) and a reduction in FVC z score of 0.13 (95% CI = -0.25, -0.01). Additionally PM2.5 during postnatal months 23-39 was associated with a reduction in FEF25-75% z score of 0.31 (95% CI = -0.57, -0.05). Methodological tools enhanced our ability to combine multisite data while accounting for study heterogeneity. Ambient PM2.5 exposure in early childhood was associated with lung function reductions in middle childhood.

Study of pulmonary function tests in workers of rurally located flour mills

Background: Agro-based industrial works like flour milling are a significant component in the industrial arena of Kerala. In milling industry, dusts are produced in substantial quantities and inhalation of which can result in pulmonary impairment in workers. In such situations, spirometric evaluation can aid in the diagnosis and prognosis of pulmonary diseases. Aims and Objectives: The aims of this study were to assess the effect of flour dust on pulmonary function among flour mill workers and to study the variation in pulmonary function among workers according to duration of exposure and their working environment in the factory. Materials and Methods: A cross-sectional study was conducted in three wheat flour mills. Subjects were selected after proper exclusion and after getting informed consent. In the present study, 79 flour mill workers aged more than 20 years and employed for more than 1year, were considered and their FVC,FEV1,FEV1/FVC,PEFR and FEF25-75% values were assessed. The objective was to find out the effect of their duration of employment and exposure to dust on their spirometric parameters based on their type of job and age. These parameters were tested using a portable electronic spirometer in the factory premises. Results: The study showed no significant relation of these parameters with duration of employment and dust exposure. However, there was significant reduction in FVC and FEV1 with increasing age. Conclusion: Even though apparently normal PFT values are obtained in many subjects, these may be on the extremes of normal spectrum.

Personal exposure to household air pollution and lung function in rural Bangladesh: A population-based cross-sectional study

ABSTRACT We assessed whether personal exposure to household air pollution [PM2.5 and black carbon (BC)] is associated with lung functions (FEV1, FVC, and their ratio) in non-smoking adults in rural Bangladesh. We measured personal exposure to PM2.5 using gravimetric analysis of PM2.5 mass and BC by reflectance measurement between April 2016 and June 2019. The average 24-hour PM2.5 and BC concentration was 141.0μgm−3 and 13.8μgm−3 for females, and 91.7 μgm−3 and 10.1 μgm−3 for males, respectively. A 1 μgm−3 increase in PM2.5 resulted in a 0.02 ml reduction in FEV1, 0.43 ml reduction in FVC, and 0.004% reduction in FEV1/FVC. We also found a similar inverse relationship between BC and lung functions (9.6 ml decrease in FEV1 and 18.5 ml decrease in FVC per 1μgm−3 increase in BC). A higher proportion of non-smoking biomass fuel users (50.1% of the females and 46.7% of the males) had restrictive patterns of lung function abnormalities, which need further exploration.

Impulse oscillometry (IOS) for detection of exercise induced bronchoconstriction in children with asthma ages 6–15 years

Objectives To determine the discriminatory value of various impulse oscillometry (IOS) parameters, and to find the cutoff value of the appropriate parameter for identifying exercise-induced bronchoconstriction (EIB) in children with asthma. Methods This cross-sectional study was conducted in India from October 2016 to March 2018 in children with asthma who were 6–15 years of age. One hundred and five children were enrolled and subjected to pre-exercise IOS and spirometry followed by free running treadmill test as an exercise challenge. All children could achieve minute ventilation >17.5–21 times of FEV1 during the exercise challenge test. Then, IOS and spirometry were performed at 10 ± 2, 20 ± 2, and 30 ± 2 min post-exercise challenge. EIB was defined as reduction of FEV1 ≥10% within 30 min of exercise. For purposes of analysis, the children were grouped into two categories: “EIB Present” or “EIB Absent”. Results The prevalence of EIB in our study was 20.95% (n = 22). ΔR5max percentage within 30 min post-exercise (AUC 0.74; 95% CI: 0.64, 0.84) had the best discriminating capacity among all IOS parameters for identifying EIB. A cutoff value of 14.1% increase in R5 within 30 min post-exercise was obtained for detection of EIB (sensitivity—95.45%, specificity—50.6%, PPV—33.87% and NPV—97.67%). Conclusions A percentage change in R5 with a cutoff value of 14.1% increase post-exercise had the best discriminatory capacity among all IOS parameters for detection of EIB in children with asthma. However, low positive predictive value (PPV) with high negative predictive value (NPV) made this cutoff value more apt to rule out EIB.

Pulmonary Function Test Results for Patients Treated on a Two-Institution, 4DCT-Ventilation Functional Avoidance Prospective Clinical Trial

<h3>Purpose/Objective(s)</h3> Functional imaging has been developed that uses 4DCT images along with image processing to generate lung ventilation maps (4DCT-ventilation). 4DCT-ventilation based functional avoidance uses 4DCT-images to generate plans that avoid functional regions of the lung with the goal of reducing pulmonary toxicity for lung cancer patients. A phase II, multi-center, prospective study was completed to evaluate 4DCT-ventilation functional avoidance radiotherapy. As part of the trial, pulmonary function tests (PFTs) were acquired at baseline and 3 months following radiotherapy in order to quantitatively assess pulmonary function decline. The purpose of this study is to report the results for pre- to post-treatment PFT changes for patients treated with functional avoidance radiotherapy. <h3>Materials/Methods</h3> Patients with locally advanced lung cancer receiving curative intent radiotherapy (prescription 45-75 Gy) and curative intent chemotherapy were accrued from two institutions. Each patient had a 4DCT-ventilation image generated using 4DCT scans and image processing techniques. Favorable arc geometry and optimization techniques were used to generate functional avoidance plans based on the 4DCT-ventilation images. PFTs were obtained at baseline and 3 months (median 3.4 months) following radiotherapy and included measurements of diffusing capacity for carbon monoxide (DLCO), forced expiratory volume (FEV1), and forced vital capacity (FVC). Pre- to post-treatment PFT changes are reported as mean ± standard deviation. PFT metrics were compared for patients who did/did not experience grade 2+ pneumonitis. <h3>Results</h3> 56 patients enrolled on the study had baseline and post-treatment PFTs evaluable for analysis. The median age was 65 years, 43 (76.8%) patients had stage III disease, and 29 (51.8%) had pre-existing COPD. The mean change in DLCO, FEV1, and FVC was -11.6% ± 14.2%, -5.6% ± 16.9%, and -9.0% ± 20.1%, respectively. Mean DLCO and FEV1 change were higher for patients with grade 2+ pneumonitis than for patients with < grade 2 pneumonitis (-15.4 versus -10.8% and -14.3 versus -3.9%, respectively). <h3>Conclusion</h3> The current work is the first to quantitatively characterize PFT changes for lung cancer patients treated on a prospective functional avoidance radiotherapy study. Large review studies show mean DLCO reductions of -15.3% (range -10% to -26%) and mean FEV1 reductions of -5.5% (range -1% to -24%) for lung cancer patients treated with standard chemoradiation. In comparison to patients treated with standard thoracic chemoradiation, our data qualitatively show that functional avoidance resulted in less of a decline in DLCO and similar declines of FEV1. The presented data can help elucidate the potential pulmonary function improvement with functional avoidance radiotherapy using a quantitative, PFT-based, pulmonary function end-point.

Particle radioactivity from radon decay products and reduced pulmonary function among chronic obstructive pulmonary disease patients

BackgroundRadon (222Rn) decay products can attach to particles in the air, be inhaled, and potentially cause airway damage. Research questionIs short-term exposure to particle radioactivity (PR) attributable to radon decay products emitted from particulate matter ≤2.5 μm in diameter (PM2.5) associated with pulmonary function in chronic obstructive pulmonary disease (COPD) patients? Study design and methodsIn this cohort study, 142 elderly, predominantly male patients with COPD from Eastern Massachusetts each had up to 4 one-week long seasonal assessments of indoor (home) and ambient (central site) PR and PM2.5 over the course of a year (467 assessments). Ambient and indoor PR were measured as α-activity on archived PM2.5 filter samples. Ratios of indoor/ambient PR were calculated, with higher ratios representing PR from an indoor source of radon decay. We also considered a measure of outside air infiltration that could dilute the concentrations of indoor radon decay products, the indoor/ambient ratio of sulfur concentrations in PM2.5 filter samples. Spirometry pre- and post-bronchodilator (BD) forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC) were conducted following sampling. Generalized additive mixed models were adjusted for meteorologic variables, seasonality, and individual-level determinants of pulmonary function. We additionally adjusted for indoor PM2.5 and black carbon (BC). ResultsPR exposure metrics indicating radon decay product exposure from an indoor source were associated with a reduction in FEV1 and FVC. Patients in homes with high indoor PR (≥median) and low air infiltration (<median) compared to others had a −26.9 (95% CI: −61.4, 7.7) mL and −75.4 (95% CI: −128.6, −22.2) mL reduction in post-BD FEV1 and FVC, respectively. These associations remained similar after PM2.5 and BC adjustment. InterpretationOur findings raise concern about the harmful effects of PR exposures attributable to residential radon on pulmonary function in patients with COPD.

Spirometric Indices of Charcoal Smoke Exposed Food Grillers in Yenagoa South-South, Nigeria

Background: Pulmonary function is an important marker of the effects of air pollution on the exposed population. Mild to moderate reductions of FEV1/FVC, FEV1, FEV1%, PEF, and FEF25–75 have been associated with the exposure to biomass burning in cross-sectional studies. Some hospital-based case-control studies, confirm that people exposed to biomass smoke have high risk for developing airflow obstruction with significant reduction of FEV1 and FEV1/FVC. However, none of these studies has evaluated lung function parameters among charcoal smoke exposed food grillers. Therefore this index study took a look at spirometric indices among food grillers exposed to charcoal smoke in Yenagoa, South-South Nigeria. Methods: This was a comparative observational cross-sectional study of charcoal smoke exposed spirometric indices of food grillers compared to fruit sellers The Medical Research Council (MRC) Questionnaire was administered to participants and a “one-on-one” interview was conducted by the researcher using the questionnaires.Information obtained included socio-demographic characteristics such as age, gender, marital status and level of education. Spirometry was performed in accordance with the ATS/ERS using standard single reusable turbine spirometer (MIR Spirobank II Basic; manufactured by P &amp; A Medical Limited). Spirograms that met the ATS/ERS criteria for acceptability were used. Information obtained with the spirometer were FEV1, FVC, FEV1/FVC, PEF and FEF25-75. A portable HANA analogue weight machine was used to weigh the study participants and a flexible plastic tape measure was used to measure the heights of participants Results: A total of one hundred and sixty (160) participants made up of eighty (80) food-grillers and fruit-sellers (controls) respectively were recruited for this study. A normal lung function pattern was found in 60 (75.0%) of food-grillers and 72 (90.0%) of controls. This shows that more fruit-sellers had normal lung function pattern, and this was statistically significant (p = 0.013). Obstructive pattern was found in 16 (20.0%) of food-grillers and 6 (7.5%) of controls (p = 0.022). The mean lung function values for food-grillers compared to fruit sellers were: FEV1=2.8±0.5L vs 3.2±0.5 (72.3±5.8% predicted); FVC=3.6±0.6L vs 3.9±0.8 (76.8±6.6% predicted), FEV1/FVC=78.5±4.9 vs 85.3 ±5.3 (77.1±5.4% predicted); PEF=5.7± 1.2L/s vs 6.9 ±2.9 (81.6±7.3% predicted) and FEF25-75=2.8±0.8L/s vs 3.0 (±0.4) (80.5±15.3% predicted). The values were statistically different between food-grillers and controls (p &lt; 0.001). Conclusion: Exposure to charcoal smoke is associated with the development of lung function abnormalities and reduction in lung function parameters. Increasing exposure time to charcoal smoke increase the likelihood of lung function abnormalities.

Cross-sectional and longitudinal relationships between urinary 1-bromopropane metabolite and pulmonary function and underlying role of oxidative damage among urban adults in the Wuhan-Zhuhai cohort in China

1-bromopropane is a US Environmental Protection Agency-identified significant hazardous air pollutant with concerned adverse respiratory effect. We aimed to investigate the relationship between 1-bromopropane exposure and pulmonary function and the underlying role of oxidative damage, which all remain unknown. Pulmonary function and urinary biomarkers of 1-bromopropane exposure (N-Acetyl-S-(n-propyl)-L-cysteine, BPMA) and oxidative damage to DNA (8-hydroxy-deoxyguanosine, 8-OHdG) and lipid (8-iso-prostaglandin-F2α, 8-iso-PGF2α) were measured for 3259 Chinese urban adults from the Wuhan-Zhuhai cohort. The cross-sectional relationship of BPMA with pulmonary function and the joint relationship of BPMA and 8-OHdG or 8-iso-PGF2α with pulmonary function were investigated by linear mixed models. The mediating roles of 8-OHdG and 8-iso-PGF2α were evaluated by mediation analysis. Additionally, a panel of 138 subjects was randomly convened from the same cohort to evaluate the stability of BPMA repeatedly measured in urine samples collected over consecutive three days and intervals of one, two, and three years, and to estimate the longitudinal relationship of BPMA with pulmonary function change in three years. We found each 3-fold increase in BPMA was cross-sectionally related to FVC and FEV1 reductions by 29.88-mL and 25.67-mL, respectively (all P < 0.05). Joint relationship of BPMA and 8-OHdG rather than 8-iso-PGF2α with reduced pulmonary function was observed. Moreover, 8-OHdG significantly mediated 9.44% of the BPMA-related FVC reduction. Findings from the panel revealed a fair to excellent stability (intraclass correlation coefficient: 0.43–0.79) of BPMA in repeated urines collected over a period of three years. Besides, BPMA was longitudinally related to pulmonary function reduction in three years: compared with subjects with persistently low BPMA level, those with persistently high BPMA level had 79.08-mL/year and 49.80-mL/year declines in FVC and FEV1, respectively (all P < 0.05). Conclusively, 1-bromopropane exposure might impair pulmonary function of urban adult population, and oxidative DNA damage might be a potential mechanism underlying 1-bromopropane impairing pulmonary function especially FVC.

Effect Of Exercise-specific Mask On Respiratory Function In Athletes With And Without Exercise Induced Bronchoconstriction

PURPOSE: Heavy ventilation is a known factor in exercise induced bronchoconstriction (EIB), leading to airway hyperresponsiveness in endurance athletes over time. How an exercise-specific mask designed for heavy ventilation affects EIB status and overall respiratory function following intense exercise is not well studied. Thus, we aimed to determine the effect of an exercise-specific facemask on airway function post-exercise in athletes with and without EIB at a normal indoor temperature. METHODS: Male (n=13) and female (n=7) athletes underwent two separate graded exercise tests to fatigue on a treadmill at 20 °C (20-40 % RH) while wearing an exercise-specific mask in one test (M) and unmasked (UM) in the other. Forced vital capacity (FVC), forced expiratory volume in 1 second (FEV1), peak expiratory flow (PEF), forced expiratory flow at 25-75% (FEF25-75), and forced expiratory flow at 50% (FEF50) were measured pre and at 3,6,10,15, 20, & 30 min post-exercise. Participants with a >10% reduction in FEV1 post-exercise (EIB+), those with an FEV1 reduction not meeting the threshold for EIB+ (EIB suspect), and participants without EIB (EIB-) were compared. RESULTS: Overall (n = 20) percentage of baseline post-exercise was improved (p>0.05) in the M condition compared to the UM condition for FEV1 (92.8 vs 92.1), FVC (91.4 vs 90.6), PEF (93.3 vs 87.2), FEF25-75 (93.5 vs 88.3) and FEF50 (93.3 vs 87.7). When EIB+ (n=3) and EIB- (n=12) subjects were compared, the magnitude of the difference in the M condition was smaller than that of the UM condition for all spirometry measures except for PEF. The magnitude of these differences between EIB+ and EIB- in the UM condition was reduced the most in the M condition for FEF50 (26.6% UM vs 11.0% M) and FEF25-75 (30.0% UM vs 20.4% M). The face mask reduced the absolute drop in FEV1 post-exercise in 67% of EIB+ subjects, 40% of EIB suspect subjects, and 42% of EIB- subjects. CONCLUSIONS: Wearing an exercise-specific mask attenuates reductions in respiratory function post-exercise in EIB+ participants. However, EIB suspect and EIB- athletes may also benefit from wearing a mask designed for heavy ventilation exercise. To fully understand the protective benefits of a mask in high ventilation athletes, provocation tests with post-exercise spirometry in both M and UM conditions should be performed.

Cross-sectional and longitudinal associations of acrolein exposure with pulmonary function alteration: Assessing the potential roles of oxidative DNA damage, inflammation, and pulmonary epithelium injury in a general adult population.

Acrolein is a significant high priority hazardous air pollutant with pulmonary toxicity and the leading cause of most noncancer adverse respiratory effects among air toxics that draws great attention. Whether and how acrolein exposure impacts pulmonary function remain inconclusive. To assess the association of acrolein exposure with pulmonary function and the underlying roles of oxidative DNA damage, inflammation, and pulmonary epithelium integrity. Among 3,279 Chinese adults from the Wuhan-Zhuhai cohort, associations of urinary acrolein metabolites (N-Acetyl-S-(2-carboxyethyl)-L-cysteine, CEMA; N-Acetyl-S-(3-hydroxypropyl)-L-cysteine, 3HPMA) as credible biomarkers of acrolein exposure with pulmonary function were analyzed by linear mixed models. Joint effects of biomarkers of oxidative DNA damage (8-hydroxy-deoxyguanosine), inflammation (C-reactive protein, CRP), and pulmonary epithelium integrity (Club cell secretory protein, CC16) with acrolein metabolites on pulmonary function and the mediating roles of these biomarkers were assessed. Besides, a subgroup (N=138) was randomly recruited from the cohort to assess the stabilities of acrolein metabolites and their longitudinal associations with pulmonary function change in three years. Significant inverse dose-response relationships between acrolein metabolites and pulmonary function were found. Each 10-fold increment in CEMA, 3HPMA, or ΣUACLM (CEMA+3HPMA) was cross-sectionally related to a 68.56-, 40.98-, or 46.02-ml reduction in FVC and a 61.54-, 43.10-, or 50.14-ml reduction in FEV1, respectively (P<0.05). Furthermore, acrolein metabolites with fair to excellent stabilities were found to be longitudinally associated with pulmonary function decline in three years. Joint effects of acrolein metabolites with 8-hydroxy-deoxyguanosine, CRP, and CC16 on pulmonary function were identified. CRP significantly mediated 5.97% and 5.51% of CEMA-associated FVC and FEV1 reductions, respectively. 8-hydroxy-deoxyguanosine significantly mediated 6.78%, 6.88%, and 7.61% of CEMA-, 3HPMA-, and ΣUACLM-associated FVC reductions, respectively. Acrolein exposure of general adults was cross-sectionally and longitudinally related to pulmonary function decline, which was aggravated and/or partly mediated by oxidative DNA damage, inflammation, and pulmonary epithelium injury.

REGN1908/1909 prevented cat allergen–induced early asthmatic responses in an environmental exposure unit

The dominant allergen in cat dander, Felis domesticus allergen 1 (Fel d 1), is a persistent trigger for allergic rhinitis and asthma symptoms. We evaluated the efficacy of Fel d 1 monoclonal antibodies (REGN1908/1909) in preventing cat allergen-induced early asthmatic responses (EARs) in cat-allergic patients with mild asthma. Patients were randomized to single-dose REGN1908/1909 600 mg (n= 29) or placebo (n= 27). The FEV1 was measured for up to 4 hours in a cat allergen environmental exposure unit up to 85 days after dosing. Assessments included between-group differences in change from baseline in FEV1 area under the curve (AUC; 0-2 hours) and incidence of EAR (FEV1 reduction ≥20%). NCT03838731. Single-dose REGN1908/1909 significantly prevented reductions in FEV1 on days 8, 29, 57, and 85. Most REGN1908/1909 patients did not have an EAR by 4 hours (the last time point tested). In contrast, placebo-treated patients experienced a ≥20% mean FEV1 reduction on days 8, 29, 57, and 85 after dosing, with most experiencing an EAR within 1 hour. REGN1908/1909-treated patients tolerated 3-fold higher allergen quantities (P< .05 at all time points) versus placebo. REGN1908/1909 substantially reduced skin test reactivity to cat allergen versus placebo at all time points tested (nominal P< .001). REGN1908/1909 was generally well tolerated; no serious adverse events or deaths were reported. Single-dose REGN1908/1909 significantly prevented reductions in FEV1 in cat-allergic patients with mild asthma on cat allergen environmental exposure unit exposure at 8 days and up to 85 days after dose.

Risk assessment and dose-effect of co-exposure to benzene, toluene, ethylbenzene, xylene, and styrene (BTEXS) on pulmonary function: A cross-sectional study

Inhalation is the most frequent route and the lung is the primary damaged organ for human exposure to benzene, toluene, ethylbenzene, xylene, and styrene (BTEXS). However, there is limited information on the risk and dose-effect of the BTEXS mixture on pulmonary function, particularly the overall effect. We conducted a cross-sectional study in a petrochemical plant in southern China. Spirometry and cumulative exposure dose (CED) of BTEXS were used to measure lung function and exposure levels for 635 workers in 2020, respectively. Forced vital capacity (FVC) and forced expiratory volume in 1 s (FEV1) were tested and interpreted as percentages to predicted values [FVC or FEV1% predicted], and FEV1 to FVC ratio [FEV1/FVC (%)]. We found the reduction in FVC% predicted and the risk of lung ventilation dysfunction (LVD) and its two subtypes (mixed and restrictive ventilation dysfunction, MVD, and MVD) were significantly associated with BTEXS individuals. In addition, pulmonary function damage associated with BTEXS was modified by the smoking status and age. Generalized weighted quantile sum (gWQS) regressions were used to estimate the overall dose-effect on lung function damage induced by the BTEXS mixture. Our results show wqs, an index of weighted quartiles for BTEXS, was potentially associated with the reduction in FVC and FEV1% predicted with the coefficients [95% confidence intervals (CI)] between −1.136 (−2.202, −0.070) and −1.230 (−2.265, −0.195). Odds ratios (ORs) and 95% CIs for the wqs index of LVD, MVD, and RVD were 1.362 (1.129, 1.594), 1.323 (1.084, 1.562), and 1.394 (1.096, 1.692), respectively. Furthermore, xylene, benzene, and toluene in the BTEXS mixture potentially contribute to the development of lung function impairment. Our novel findings demonstrated the dose-response relationships between pulmonary function impairment and the BTEXS mixture and disclosed the potential key pollutants in the BTEXS mixture.

Influences of Breathing Exercises and Breathing Exercise Combined with Aerobic Exercise on Changes in Basic Spirometry Parameters in Patients with Bronchial Asthma

Scientific evidence shows that breathing or aerobic programs can improve the quality of life of asthma patients. The aim of this work was to find out the influences of breathing exercises and breathing exercises combined with aerobic exercise on changes in spirometry parameters in patients with bronchial asthma. Participants: The group consisted of 33 women with bronchial asthma—mild to moderate persistent levels of FEV1 reduction (80–50%)—with a mean age of 34.73 ± 1.53 years. They were randomly assigned to experimental group 1 (EX1), experimental group 2 (EX2) or the control group (CG). Materials and methods: Changes in spirometry parameters were evaluated over a 16-week period in the three groups: CG (placebo), EX1 (breathing exercises) and EX 2 (combination of breathing exercises with an aerobic program). To evaluate the pre-training and post-training diagnostics, we used MIR Spirobank II. The influences of the experimental and control factors were assessed using the following dependent variables: forced vital capacity (FVC), forced expiratory volume in one second (FEV1), Tiffeneau–Pinelli index (FEV1/FVC ratio), peak expiratory flow (PEF) and forced mid-expiratory flow (FEF25–75%). We used the Wilcoxon t-test and the Kruskal–Wallis test to evaluate the differences in the measured parameters. To examine the effect of our protocols, we used effect size (ES). Results: In CG we observed improvements in: FVC—(5%; p &lt; 0.05; ES = 0.437). FEV1—(7.33%; p &lt; 0.01; ES = 0.585). FEV1/FVC ratio (5.27%; p &lt; 0.01; ES = 0.570). PEF (11.22%; p &lt; 0.01; ES = 0.448). FEF25–75% (7.02%; p &lt; 0.01; ES = 0.628). In EX1 we observed improvements in: FVC (5.23%; p &lt; 0.01; ES = 0.631), FEV1 (20.67%; p &lt; 0.01; ES = 0.627), FEV1/FVC ratio (16.06%; p &lt; 0.01; ES = 0.628), PEF (13.35%; p &lt; 0.01; ES = 0.627) and FEF25–75% (13.75%; p &lt; 0.01; ES = 0.607). In EX2 we observed improvements in: FVC (9.12%; p &lt; 0.01; ES = 0.627), FEV1 (27.37%; p &lt; 0.01; ES = 0.626), FEV1/FVC ratio (15.32%; p &lt; 0.01; ES = 0.610), PEF (30.66%; p &lt; 0.01; ES = 0.626) and FEF25–75% (58.99%; p &lt; 0.01; ES = 0.626). Significant differences compared to the control group were observed in EX1 for FEV1 (p &lt; 0.05) and FEV1/FVC ratio (p &lt; 0.01); and in EX2 for FEV1 (p &lt; 0.05), FEV1/FVC ratio (p &lt; 0.01), PEF (p &lt; 0.05) and FEF (p &lt; 0.05). A significant difference between EX1 and EX2 was observed in PEF (p &lt; 0.05). Conclusions: It appears to be that combination of breathing exercises with aerobic activities is a more beneficial option for patients with bronchial asthma.