Objective: Preeclampsia-eclampsia (PE) has a worldwide incidence of 5–10%, accounting for 18% of maternal deaths.In PE albuminemia is diminished by increased capillary permeability secondary to endothelial damage and proteinuria. Reduction of colloid osmotic pressure (PCO) produces interstitial edema and a decreasing blood volume, stimulating the renin-angiotensin-aldosterone system. AIM:Was to determine if hypoalbuminemia is PE cause in a population of high risk pregnant women attended in a Gestational Hypertension Unit of the San Carlos Clinical Hospital (Madrid, Spain) and in the High Obstetric Risk Unit of the Hospital de Clinics Dr. Manuel Quintela (Montevideo, Uruguay). Design and method: Retrospective, observational, descriptive-analytical study. Pregnant women with chronic or gestational hypertension were included at the 32th week of gestation. The PCO and the Briones Index (IB: PCO / mean arterial pressure) were calculated Results: 193 pregnant women were included. 25.4% had PE, 3.6% developed HELLP. A single case of eclampsia was recorded. The demographic variables are described in Table 1. Hypoalbuminemia (plasmatic albumin < 3 g/dl) was observed in 13 patients (11 developed PE). We found that a value of albuminemia <3.3 g/dl had a RR 1.8 (95% CI:1.01–3.2, p = 0.036) for the development of PE in the analysis of multivariate regression adjustment binary logistics. These pregnant women had children with a lower birth weight, (−319 gr, p < 0.004) and a lower gestational age at birth (36.7 ± 3 vs 38 ± 2.4;p < 0.002). Patients that developed PE had lower PCO than the group without PE, (19.05mmHg vs 20.33mmHg, p < 0.004), and lower IB (0.10 ± 0.02 vs 0.12 ± 0.02; p = 0.000). This index had a better predictive capacity than albumin 0.74 (95% CI 0.64–0.81) vs 0.64 (95% CI:0.53–0.74) p = 0.044. Conclusions: There is a high incidence of PE, as expected in high-risk patients. Albuminemia <3.3 g/dl is associated with a higher risk of PE, lower birth weight and lower gestational age. The PCO and the Briones Index are very valid for the quantitative assessment of capillary leakage.