The wind-driven aerodynamic noise of super-high-rise building facades not only affects the experience of use inside the building but also reduces the life cycle of building facade materials to some extent. In this paper, we are inspired by the micro-groove structure of shark skin with damping and noise reduction properties and apply bionic skin to reduce the aerodynamic noise impact of super-high-rise buildings. The aerodynamic noise performance of smooth and super-high-rise building models with bionic grooves is simulated via CFD to investigate the noise reduction performance of different bionic groove patterns, such as I-shape, ∪-shape, V-shape, and ∩-shape patterns, and their corresponding acoustic noise reduction mechanisms. This study showed that the bionic shark groove skin has a certain noise reduction effect, and the I-shaped groove has the best noise reduction effect. By applying bionic skin, the aerodynamic noise of super-high-rise buildings can be effectively reduced to improve the use experience and environmental quality of the buildings and provide a new research idea and application direction for the aerodynamic noise reduction design of building facades.