Introduction: Enhanced Recovery After Surgery (ERAS) is a multimodal perioperative program to reduce postoperative morbidity. A number of European institutions reported improvements in short-term outcomes following ERAS implementation for pancreas surgery; however there are no similar data from the US. In this study, we examined early outcomes following ERAS implementation at a major US academic institution among patients undergoing pancreaticoduodenectomy (PD) or distal pancreatectomy. Methods: Using institutional NSQIP outcomes from 2013-2017 we identified patients who underwent PD or distal pancreatectomy before and after implementation of ERAS (May 2016). Categorical variables were compared using Fischer exact test. LOS was compared using Mann-Whitney U test. Statistical significance was defined as p value < 0.05. Results: 247 patients underwent PD (164 before and 83 following ERAS) and 149 patients underwent distal pancreatectomy (111 before and 38 following ERAS). Of those undergoing PD, there was a trend towards reduced median LOS following ERAS implementation from 10 days (range 5–79 d; IQR 7) to 8 days (range 4–52 d; IQR 8)(p = 0.17). Additionally, there was a reduction in 30-day readmission rates (18.9% to 13.3%, p = 0.29). For patients undergoing distal pancreatectomy, there was no difference in median LOS (6 vs. 5d; p = 0.55). Conclusions: The early results following ERAS implementation for pancreas surgery demonstrate a reduced LOS for PD patients without increased readmission rates. Similar LOS improvements did not apply to distal pancreatectomy. Given that PD is a complex surgical procedure with persistently high morbidity, ERAS may have a more profound impact on short-term outcomes among these patients.
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