Objective To explore the relationships among psychological empower, role stressors and job burnout in nurses. Methods From February to October of 2014, by random sampling method, 420 nurses from three hospitals of Jinzhou city of Liaoning province were selected and assessed with the psychological empower questionnaires, the job burnout questionnaire, role stressors questionnaire.The data were analyzed using pearson correlation analysis and logical multiple linear regression analysis. Results The average score of job burnout was (59.58±18.30) points, the average score of psychological empower was (38.87±7.05) points. Job burnout and each dimension were negative correlated with self-determination of the psychological empower (r=-0.25--0.34, P<0.05) and self-efficacy ( r=-0.08--0.53, P<0.05). The scores of role stressors were positively correlated with the scores of emotional exhaustion(r=0.17-0.43, P<0.05)and cynicism (r=0.07-0.46, P<0.05). Multiple regression analysis showed that age(β=-0.104), education level(β=-0.237), seniority(β=-0.334), self-determination(β=-0.152), self-efficacy(β=0.127), role ambiguity(β=0.284), role overload(β=0.325) were influencing factors of nursing burnout. Conclusion Nurses role stressors and psychological empower can predict nurses’ burnout, so nurse managers can increase the level of authority to relieve psychological job burnout by reducing caregiver stress source. Key words: Nurses; Job burnout; Role stressors; Psychological empower; Mental Health