Digital image compression is applied to reduce camera bandwidth and storage requirements, but real-time lossless compression on a high-speed high-resolution camera is a challenging task. The article presents hardware implementation of a Bayer colour filter array lossless image compression algorithm on an FPGA-based camera. The compression algorithm reduces colour and spatial redundancy and employs Golomb–Rice entropy coding. A rule limiting the maximum code length is introduced for the edge cases. The proposed algorithm is based on integer operators for efficient hardware implementation. The algorithm is first verified as a C++ model and later implemented on AMD-Xilinx Zynq UltraScale+ device using VHDL. An effective tree-like pipeline structure is proposed to concatenate codes of compressed pixel data to generate a bitstream representing data of 16 parallel pixels. The proposed parallel compression achieves up to 56% reduction in image size for high-resolution images. Pipelined implementation without any state machine ensures operating frequencies up to 320 MHz. Parallelised operation on 16 pixels effectively increases data throughput to 40 Gbit/s while keeping the total memory requirements low due to real-time processing.