Background: Today, job burnout is a familiar term among intensive care nursing staff, causing serious emotional, psychological, physical and social problems for those who suffer from it. Job Burnout leads to job dissatisfaction, low organizational commitment, and absenteeism from work. Coping has been viewed as a stabilizing factor that may assist in managing demands include attempts to master the environment or to minimize, avoid, tolerate, or accept stressful conditions through using coping strategies. Aim of the study: Identify Burnout and Coping Strategies among Nursing Staff in Intensive Care Units at Mansoura University Hospitals. Subjects and Methods: a descriptive design was utilized. The sample consisted of 316 nursing staff who have either diploma or baccalaureate degree with at least one year experience. Two tools were used for data collection first; Maslach Burnout Inventory that included 22 questions and, second Ways of Coping Questionnaire sheet (WOCQ) it consists of 66 items. Conclusion: both burnout and coping strategies among nursing staff in intensive care units at Mansoura University Hospitals were in moderate level. There was statistical significant difference between burnout and coping strategies. That means the more burnout experienced, the more coping strategies will used. Recommendation: it is recommended that work redesign plans as well as early assessment and intervention may be helpful in the reduction of job burnout in nursing staff working in Mansoura university hospitals.