Red Onion Extract Research Articles

Ameliorative Effect of Allium Cepa L. (Red Onion) Extract against Potassium Bromate Induced Intestinal Injury‏ In Rats

Potassium bromate is an oxidizing agent and one of the cheapest dough improvers in the baking and food industry. This agent is classified as carcinogenic in rats and nephrotoxic in both man and experimental animals when given orally. The red onion, Allium cepa, is used in the daily diet for taste. Compounds in onions also have various medicinal properties, such as being anticancer, antifungal, antioxidant, anti-ulcer, and anti-inflammatory. We therefore sought to investigate whether aqueous extract of red onion would be protective against injury to the intestine
 Materials and Methods: 36 Wistar male rats were divided into 6 batches. Over a 4-weeks experimental period, group I rats served as a control and group II received 100 mg/kg b.w of KBrO3 on the 24th and 27th days. Group III received red onion juice at 1ml/100 g bw every day and 100 mg/kg bw of KBrO3 on the 24th and 27th days. Group IV received 50 mg/kg bw of KBrO3 twice per week, group V received red onion juice daily at 1ml/100 g bw and 50 mg/kg bw of KBrO3 twice per week, and group VI received 30 mg/kg KBrO3 every day. The body and four organs weights, including the kidney, testis, lung and liver of all experimental rats were measured. The histopathological investigation was performed for the intestine tissues of all groups.
 Results: KBrO3-treated small intestines exhibited destruction in the villi, decreased number of goblet cells, crypt loss and cell infiltration in the epithelial lining. Treatment with extract of red onion appeared to significantly ameliorate the toxic effects of KBrO3.
 Conclusion: Our findings suggest that red onion ameliorates the extent of intestinal injury and appears to act as an antioxidant. This study supports that red onion has beneficial properties, although no direct clinical conclusions can be drawn from these data.

Antioxidant and antimicrobial activity of red onion (Allium cepa, L.) extract nanoencapsulated in native seed gums coating and its effect on shelf-life extension of beef fillet

Antioxidant and antimicrobial activity of red onion (Allium cepa, L.) extract nanoencapsulated in native seed gums coating and its effect on shelf-life extension of beef fillet

The Effect of Trichoderma and Onion Extract on the Success of Grafting in Mango Seedlings

This study aims to determine the effect of Trichoderma asperellum Tc-Clkt-01 and shallot extract and their interaction on the success of grafting mango seedlings. The factorial experiments in this study were arranged in a completely randomized design (CRD). The first factor is Trichoderma consisting of without and with Trichoderma. The second factor was the concentration of shallot extract above: 0, 15, and 30 ml.l−1. With three replications, 18 experimental units were obtained. The variables observed were: shoot appearance time (days) and shoot growth length (mm) one to four weeks after grafting. All data from the observations were analyzed using ANOVA at the 5% level; the average of each treatment was compared with controls (without Trichoderma and without red onion extract). Trichoderma sp. isolate Tc-Clkt-01 accelerated the emergence time of shoots by 26.87% and increased shoot length growth by 41.76-43.71% compared to the control. Onion extract at a concentration of 15 ml.L−1 accelerated the emergence of shoots by 10.45% and increased shoot length increase by 20.59% compared to the control. The combination of Trichoderma and shallot extract at a concentration of 30 ml.l−1 accelerated the emergence of shoots by 23.17% and increased shoot length by 32.94% compared to the control.

Rojo Duro Red Onion Extract Loaded Spray Thermogel as a Sustainable Platform for the Treatment of Oral Mucosa Lesions.

The urgent need for new green and sustainable models is ground for the current demand of innovative renewable resource based pharmaceutical products. We propose a Rojo Duro skin onion extract loaded poloxamer/chitosan spray mucoadhesive thermogel aimed at solving current limitations in oral mucosits treatment. Being among the main side effects of radio- and chemotherapy, effective treatment of buccal lesions still represents an unmet medical need. The obtained thermogel combined optimal gelling capacity, release behavior, sprayability, mucoadhesion properties, while maintaining the extract antioxidant and antimicrobial properties. The product preserved all properties when stored for 1 month as a freeze-dried powder at 4°C. This potential new product is highly translational, as it combines a recognized safety to administration/application advantages, as well as simplicity and sustainability.

Anti-Microbial Activities of Shallots (Allium cepa L.) Extract and Garlic (Allium sativum L.) Extract on the Growth of Peat Soil Bacteria

This study aims to examine the antimicrobial activity of red onion ( Allium cepa L.) and garlic ( Allium sativum L.) extracts on the growth of peat soil bacteria. This type of research is an experimental study using a Completely Randomized Design with four levels of treatment. Test for bacterial activity using the agar diffusion method with the paper disc technique. Data were analyzed statistically using One Way Anova and the Games-Howell post-hoc test at the 5% significance level. The results showed that red onion ( Allium cepa L.) and garlic ( Allium sativum L.) extracts had antimicrobial activity against the growth of tested bacteria as indicated by the presence of a clear zone as an indicator of inhibition of bacterial growth. Garlic has better antimicrobial activity seen from the diameter of the clear zone that appears in the garlic extract treatment ranging from 8-13 mm, whereas in the treatment of onions it ranges from 3–5 mm.

Optimization of microwave extraction method of phenolic compounds from red onion using response surface methodology and inhibition of lipoprotein low-density oxidation

In the present study, we have optimized by surface response methodology (BBD model) phenolic compounds recovery using microwave-assisted extraction (MAE) as an innovative technique. The extraction was carried out under different experimental conditions: ethanol/water (x1, 30–80 %), time (x2, 30–180 s), microwave power (x3, 500–900 W) and solvent to sample ratio (x4, 20:1 40:1, v/w). Total phenolics content (TPC) and antioxidant activities (AA) of onion extract were investigated on 2,2−9-azino-bis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS+), 1,1-diphenyl-2-picrylhydrazyl radical (DPPH), oxygen radical absorbance capacity (ORAC) tests, and on biological model oxidation, human low-density lipoprotein (LDL). The maximum predicted TPC under the optimal MAE conditions (70 % ethanol), 700 W microwave power, 65 s extraction time and 25 mL g–1 solvent to solid ratio), was 10.90 ± 0.88 mg GAE g–1 DW. The AA of MAE or conventional extraction (CE) extract showed similar activities to neutralize DPPH, ABTS or AAPH derived radicals. The modified Gompertz model has been successfully used to describe CDs production kinetic in LDL Cu2+-mediated oxidation. This allowed the estimation of the lag time (Tlag) and the oxidation propagation rate (Rp) with precision. LDL oxidation assay showed that red onion extract increased significantly Tlag and giving an increased protection ratio at higher concentration (2.95 μmol L−1) of 180 % and 172 % for MAE and CE methods, respectively. However, Rp and CDs production remained constant. Results showed that microwave used for extraction does not affect the composition and antioxidant properties of onion sample. Red onion may be an important source of bioactive compounds and could promote health consumers.

Red Onion Extract Attenuates Aluminum Induced Toxicity in Swiss Albino Mice

Red Onion Extract Attenuates Aluminum Induced Toxicity in Swiss Albino Mice

Perbandingan Uji Aktivitas Antibakteri Umbi Bawang Merah (Allium Cepa L) Dan Umbi Bawang Putih (Allium Sativum) Terhadap Pertumbuhan Bakteri Shigella Dysenteriae

Background :Diarrhea is one of the causes of morbidity and mortality in infants and children around the world. One of the causes of diarrhea is Shigella sp bacteria or shigellosis. Nowadays, many antibiotics resistant to the Shigella sp bacteria are one example of chloramphenicol, so it is necessary to have other alternatives such as natural ingredients. Objective: Determine the activity of the red onion (Allium cepa L) and garlic (Allium sativum), which is known to possess antibacterial phytochemical compounds against the Shigella dysenteriae bacteria. Method: This research is a laboratory experimental study to determine antibacterial activity using the Kirby-Bauer or diffusion method of discs and to determine the presence of Minimum Inhibitory Concentration (MIC) and Minimum Bacterial Concentration (MBC). The study uses five treatments i.e., onion extracts and garlic extracts with a concentration of 30%, 40%, 50%, 60%, 70%, control positive (Ciprofloxacin), and negative control (aquadest). Results: Red onion diffusion has the best antibacterial activity at concentrations 70% while garlic has the best antibacterial activity at a concentration of 70%. In this study, there were no MIC and MBC. The MIC data analyzed with the crucial test of Kruskal-Wallis (p 0.05) i.e., in onion extract p = 0.003 and in garlic P = 0.003, which means significant. The MBC Data is analyzed by crucial test (P 0.05) in the onion extract p = 0.003 and on garlic p = 0.04. Conclusion : the disc diffusion and the MBC can be concluded that garlic extract can inhibit the growth of S. dysenteriae compared to red onion extracts. onion extracts).

Comparative electrochemical and spectroscopic analysis of the inhibition effect of molybdates and boiled red onion extract on the corrosion of tin in acidic solution

The corrosion inhibition efficiency (η%) and its passivation mechanisms of tin in 0.2 M malic acid by two different types of potential inhibitors, boiled red onion skin extracts (BROE) and molybdate (MoO4 2−), were examined and compared. The influence of the two inhibitors was evaluated by using the electrochemical polarization and the electrochemical impedance spectroscopy (EIS) methods. The electrode surface coverage was analyzed employing scanning electron microscopy (SEM) and energy-dispersive X-ray spectroscopy (EDX). The electrochemical polarization curves revealed that increasing inhibitor concentration led to a significant reduction of the tin corrosion rate. The presence of BROE and molybdates produced inhibition efficiency (η%) values of 93 and 87%, respectively. Electrochemical measurements and surface analysis have shown satisfactory agreement, that both inhibitor compounds effectively inhibited tin corrosion in 0.2 M maleic acid by forming protective inhibiting deposits that hindered the active electrochemical corrosion sites on the tin surface. Comprehensive insights into the corrosion inhibition mechanism of these compounds in a 0.2-M maleic acid environment, through the suggested equivalent circuits, are also provided.

Phytochemical Screening and Antioxidant Activity Test of Red Onion (Allium ascolinicum L.) Extract Variety of Palu Valley

The red onion of Palu valley variety is a plant that is widely found in Palu area and regarded as a leading commodity in Central Sulawesi. The purpose of this study was to examine the secondary metabolite compounds contained in red onion (Allium ascolinicum L.) of Palu valley variety and its antioxidant activity. Antioxidant activity test in this study used DPPH (1,1-Diphenyl-2-Pikrilhidrazil) as a source of free radical, and vitamin C as the comparison. The antioxidant activity of red onion extract was analyzed using a UV-Vis spectrophotometer. The red onion tuber powder was extracted by maceration using ethanol solvent. Qualitative test of onion powder showed positive results on alkaloids, flavonoids, and tannin compounds. The samples and vitamin C were tested for antioxidant activity in various extract concentrations of 10, 30, 50, 70, and 90 ppm. The results showed that red onion extract of Palu valley variety presented an IC50 value of 38.548 ppm, and vitamin C presented an IC50 value of 22.646 ppm. Based on these values, the red onion (Allium ascolinicum L.) extract is categorized as a very strong class of antioxidant which can be used as a source of natural antioxidant.

Electrochemical and surface analytical characterization study of the inhibition effect of boiled red onion extract on tin corrosion in 0.2 M Maleic acid medium.

The inhibition efficiency of boiled red onion skin extracts (BROE) against tin corrosion in 0.2 M Maleic acid has been studied using electrochemical and surface analytical methods. The electrochemical polarization curves displayed the active/passive transition of the anodic behavior of the tin electrode. The electrochemical impedance measurements demonstrated the effect of increasing BORE concentration on the inhibition efficiency (η %) (to a ηmax = 94% at 300 mg/L of BORE). The inhibition mechanism is attributed to the formation of adsorbed protective layers, on the metal surface, that fit the Langmuir adsorption isotherm model. Increasing the temperature hindered the η values.

Hypocholesterolaemic effects of fermented red onion (Allium cepa L. var aggregatum) in rats (Rattus novergicus)

Red onion is known as one of spices, and it also benefits for human health evidently. Previous study that red onion has a beneficial for cardiovascular disease, including hypocholesterolaemic Red onion contains flavonoids. The extract of red onion decreased serum total cholesterol level of rats, which is mediated by quercetin. Quercetin could be increased by fermentation as one of the new methods in drug discovery, so the biological activity also increases through fermentation. This study aimed to antihypercholesterolaemic activity of red onion fermented extract. Twenty five rats were divided in 5 groups; 2 controls [negative and positive control (atorvastatin)] with treatment groups (100, 200 and 300 mg/kg bw of fermented red onion extract. Rats were given atherogenic feed until hypercholesterolaemic All groups were given an atherogenic feed until hypercholesterolaemic. Total cholesterol of rats measured on the 7th, 14th and 21st day after they rats were treated by red onion fermented extract. Data analysed by ANOVA and continued by post hoc Duncan. All doses of red onion fermented extract decreased total cholesterol level of rats and dose of 200 mg/kg showed the strongest effect. Write the expectation for future fermented red onion has potential as a new agent cardiovascular health.

The Potential Hypoglycemic Activities of Red Onion Extracts in Alloxan-Induced Hyperglycemic Mice

Objective: The present study aimed to determine the potential effect of red onion extracts on ameliorating the blood glucose levels in alloxan-induced hyperglycemic mice.Material and Methods:Hyperglicemia was induced by single intramuscular injection of 70 mg/kg body weight of alloxan monohydrate. 24 mice were randomly assigned to four groups of 6 each including alloxan control (group AC), and three alloxan groups treated with doses 25 mg/kg body weight (group AR25), 50 mg/kg body weight (group AR50), and 100 mg/ kg body weight (group AR100) of red onion extracts. The latter three groups were treated with red onion extract for two weeks. The blood glucose levels were measured using a glucometer.Results and Discussion: The different doses of red onion extracts induced the different responses of blood glucose levels in hyperglycemia mice. The main finding of the present study revealed the significant capacity to ameliorate the blood glucose levels were shown in mice treated with 100 mg/kg body weight of red onion extracts (p<0.05).Conclusion: The red onion extracts at 100 mg/kg body weight significantly ameliorated the blood glucose in alloxan-induced hyperglycemic mice.International Journal of Human and Health Sciences Vol. 04 No. 02 April’20 Page : 98-101

Red Onion (<i>Allium cepa</i> L.) Methanolic Extract Increases Extracellular Nucleotide Hydrolysis in Rat Serum

Ectonucleotidases are enzymes involved in nucleotides metabolism. The amount of circulating nucleotides may modulate distinct pathophysiological processes in the vasculature, including platelet aggregation and vascular tone. Onion (Allium cepa L.) phenolic compounds modulate enzymatic activity. The present study evaluated the total phenolic content of red onion methanolic extract, its antioxidant capacity, and its ability to interfere in nucleotides hydrolyses in rat serum. Total phenolic content was determined with the Folin-Ciocalteau reagent using gallic acid as a standard, while total flavonoid content was obtained through the aluminum chloride colorimetric method with quercetin as a standard. Antioxidant capacity was evaluated from the ability of the extract to scavenge ABTS·+ and DPPH· radicals. ATP, ADP, AMP, and p-Nph-5'-TMP hydrolyses were colorimetrically determined in response to different onion extract concentrations (0, 125, 250, 500, or 1000 μg/mL). Phenolic content of the extract was 54.35 mg GAE 100 g-1 sample, while flavonoid content was 7.22 mg quercetin g-1 sample. The IC50 value for ABTS·+ was 374.13 ± 7.52 μg/mL, while it was 440.29 ± 15.17 μg/mL for DPPH·. Red onion extract increased ADP and p-Nph-5'-TMP hydrolysis. The results confirmed that red onion contains high content of antioxidant, mainly flavonoids, and high antioxidant capacity. Additionally, biochemical studies suggest that the increased ADP breakdown may be important to regulate vascular processes. As it occurs for other enzymes, the antioxidant capacity of onion extract may neutralize reactive oxygen species (ROS) formation and favor ectonucleotidase activity and the hydrolysis of ADP, a major platelet agonist.

PENGARUH EKSTRAK TANAMAN SEBAGAI SUMBER ZPT ALAMI TERHADAP PERTUMBUHAN SETEK TANAMAN LADA (Piper nigrum L.)

The purpose of research is to view the effect some crop extract as natural growth hormon towards pepper cutting growth, conduted in Bontomanai District of Selayar Island Regeny, during March – May 2018. This experimental research used random group of environmental design by one factor treatment, without Growth hormone submersion, coconut water 50%, red onion extract 75%, moringa leaves extract 30%, sargassum seaweed extract 25%, cow urine 15%, and Growtone 12,5%. The data was analyzed based on the F (ANOVA) test and contrast test. Growth hormone Growtone using is better than compared to coconut water, red onion, moringa leaves, sargassum seaweed and cow urine in responding, peper cutting growth. Red onion extract 75% is better than moringa leaves extract and sargassum seaweed extract towards to components of pepper cuttings growth (budding period, number of buds, bud length, root volume and the percentage of living cuttings) coconut water 50% has effect on budding period of pepper cuttings and cow urine 15% has effect on leaf wide. Sargassum extract 25% has effect on number of leaves and leaf wide.

Evaluation of the Effect of Red Onion Extract Consumption in Mice (Mus musculus)

Red onion (Allium cepa) is commonly used in human diet, representing an important source of flavonoids, with argued therapeutic values in humans. In animals, the tolerance to onion varies according to species and the quantity intake, carnivores being the most sensitive. The experiment aims to identify the negative potential effects in mice after the aqueous red onion extract consumption over 56 days. Similar to some long-term studies performed on other species using aqueous or alcoholic red onion extracts, for the mice of the experimental batch were registered the hepatic and renal disturbances, paraclinically and microscopically registered, which might limit the testing of the effects of the extracts from red onion on mice.

Antibacterial Activity of Fresh Red and White Onion (Allium cepa) Extract against Some Drug Resistant Bacteria

Antibiotics resistance is currently one of the major challenges in the health care system. The antimicrobial properties of some herbs have been used in the treatment of infectious diseases as well as disinfection of surfaces. This in a way helps overcome microbial resistance arising from indiscriminate use of synthetic antimicrobial agents for similar purpose. Some antibiotic resistant bacteria- Pseudomonas aeruginosa, Staphylococus aureus and Escherichia coli isolated from cooking wares in homes were investigated using agar well diffusion and agar dilution method to test for the antibacterial activity of fresh Allium cepa (onion) extract. All were susceptible to the fresh white and red onion extract except Staphylococus aureus which was susceptible to only the white onion extract. The diameter of zones of inhibition ranged from 2 mm-35 mm. The Minimum Inhibitory Concentration (M. I. C.) and the Minimum Bacterial Concentration (M. B. C.) values of the fresh onion juices against the test bacteria were low ranging from 3.125% v/v – 25.0% v/v. This study indicates that the fresh raw extracts of Allium cepa possess significant antibacterial potency against these antibiotic resistant bacteria.

Respons Tanaman Jahe Merah (Zingiber Officinale) Terhadap Ekstrak Bawang Merah dan Pupuk Hayati Trichoderma

This study aims to determine the vegetative growth response of saplings of red ginger (Zingiber officinale) to the administration of red onion extract and Trichoderma biological fertilizer. Experiments were arranged factorially using a completely randomized design (CRD). The first factor is the concentration of red onion extract which consists of three levels, namely: 0 gr, 125 gr, and 250 gr per liter of shallot extract; the second factor is Trichoderma biological fertilizer, consisting of: without biological fertilizer and with Trichoderma biological fertilizer. Each combination of treatments was repeated 4 times, to obtain 24 experimental units. The variables observed were plant height (cm), number of leaves, increase in stem diameter (cm), stover wet weight (gr), and dry stover weight (gr) at 24-60 days after planting (DAP). Data were analyzed by variance at the level of 5% to determine the effect of treatment, to find out the differences between treatments were carried out by 5% HSD. The results showed that there was a significant interaction effect between red onion extract and Trichoderma biofertilizer on the increase of high growth of red ginger tillers at 36 and 48 DAP. Both factors and their interactions were not significant for the number of leaves, stem diameter, wet weight, and dry stover weight. The treatment of 125 gr/l shallot extract and Trichoderma biofertilizer produced the highest response of the number of leaves and stem diameter at 60 DAP.

Assessment of the waste lubricating oils management with antioxidants vegetables extracts based resources using EPR and FTIR spectroscopy techniques

Despite the advantages of bio-sourced lubricants, they are still far from replacing petroleum energy because of their poor cold flow properties and oxidation stability, so the recycling of waste lubricating oil with antioxidant vegetables extracts based energy resources remains a key management to avoid environmental pollution by millions of tons of degraded lubricating oils, and to contribute a good economic management of oil consumption which is being depleted.The regeneration of lubricating oils using vegetable oils is a method of trapping free radicals produced during lubricant degradation due to their tribological and physico-chemical property, including renewable character and biodegradability.This study aims to evaluate the effect of Chamaerops Humilis L. (EEG) and Amposta red onion (EET) antioxidants extracts on the regeneration of waste lubricating oils, using Electron Paramagnetic Resonance (EPR) and Fourier Transform Infrared spectroscopy (FTIR) techniques. These oily extracts have chosen because of their important composition of total Phenols in the form of Catechins and Gallic acid which offer them a very effective oxidation inhibition.The obtained results show that the oily naturel extract based on Chamaerops Humilis L has an oxidation inhibitor up to 82% and 60% for Amposta Red Onion extract.

Effect of Quercetin Rich Onion Extracts on Bacterial Quorum Sensing.

Quorum sensing (QS) regulates bacterial gene expression and studies suggest quercetin, a flavonol found in onion, as a QS inhibitor. There are no studies showing the anti-QS activity of plants containing quercetin in its native glycosylated forms. This study aimed to evaluate the antimicrobial and anti-QS potential of organic extracts of onion varieties and its representative phenolic compounds quercetin aglycone and quercetin 3-β-D-glucoside in the QS model bacteria Chromobacterium violaceum ATCC 12472, Pseudomonas aeruginosa PAO1, and Serratia marcescens MG1. Three phenolic extracts were obtained: red onion extract in methanol acidified with 2.5% acetic acid (RO-1), white onion extract in methanol (WO-1) and white onion extract in methanol ammonium (WO-2). Quercetin 4-O-glucoside and quercetin 3,4-O-diglucoside were identified as the predominant compounds in both onion varieties using HPLC-DAD and LC-ESI-MS/MS. However, quercetin aglycone, cyanidin 3-O-glucoside and quercetin glycoside were identified only in RO-1. The three extracts showed minimum inhibitory concentration (MIC) values equal to or above 125 μg/ml of dried extract. Violacein production was significantly reduced by RO-1 and quercetin aglycone, but not by quercetin 3-β-D-glucoside. Motility in P. aeruginosa PAO1 was inhibited by RO-1, while WO-2 inhibited S. marcescens MG1 motility only in high concentration. Quercetin aglycone and quercetin 3-β-D-glucoside were effective at inhibiting motility in P. aeruginosa PAO1 and S. marcescens MG1. Surprisingly, biofilm formation was not affected by any extracts or the quercetins tested at sub-MIC concentrations. In silico studies suggested a better interaction and placement of quercetin aglycone in the structures of the CviR protein of C. violaceum ATCC 12472 than the glycosylated compound which corroborates the better inhibitory effect of the former over violacein production. On the other hand, the two quercetins were well placed in the AHLs binding pockets of the LasR protein of P. aeruginosa PAO1. Overall onion extracts and quercetin presented antimicrobial activity, and interference on QS regulated production of violacein and swarming motility.