Background: For efficient laser tattoo removal, photodisruption of tissue can ensure a very powerful means to shutter ink granules. At very high laser intensity level, photodisruption dominates and selective photothermolysis will have secondary effect in clearing the tattoo ink. Lower laser fluence is all what to trigger non-linear photons absorption and the generation of exploding cavitation bubbles that can tremendously hammer the ink granules.Subjects, materials, and methods: Three domestic white rabbits; each received simultaneous injections of a color pigment tattoo under general anesthesia, followed by a single session of (1064) Q.S Nd: YAG nanosecond laser pulses for tattoo removal.Results and Discussion: Spectroscopic properties of black, dark brown and red tattoo inks were studied. Near threshold laser fluence was selected to select the optimum conditions for obtaining scar-free treatment. Histological images of the biopsies, taken after thirty days of laser treatment of black, dark brown and red tattoos showed a marked reduction in pigment granules size with no appearance of hyperplasia or inflammatory cells. Coexistence of macrophages was suggested to be responsible for actively phagocytizing the laser-dispersed tattoo fragments.Conclusion: skin biopsies have demonstrated ink granules local redistribution. Photodisruption at 1064nm laser effectively targeted black and dark brown tattoo pigments by the generation of cavitation bubbles. The weaker laser light absorption of red pigments at 1064nm only showed tattoo clearance when using 532nm wavelength.