Depression in children has become a well-accepted entity today, 1–6 but its existence was denied by even experienced clinicians a generation ago. It is a disorder with diverse physical manifestations. These include disturbances of appetite, abnormalities in body weight, and multiple somatic complaints, such as headaches and vague abdominal 7 and chest pains. 8 The Diagnostic and Statistical Manual of Mental Disorders (3rd ed), (DSM-III), 9 describes the criteria for a diagnosis of major depressive disorder as follows: a dysphoric mood or pervasive loss of interest or pleasure, plus four of the following eight symptoms: (1) changes in appetite or weight, (2) sleep difficulty, (3) loss of energy, (4) psychomotor agitation or retardation, (5) loss of interest or pleasure in usual activities, (6) feelings of self-reproach or guilt, (7) complaints or evidence of diminished ability to concentrate or think, and (8) recurrent thoughts of death or suicide. Although no distinction is made among children, adolescents, and adults concerning the essential features of depressive disorders, the text of DSM-III does describe differences in associated features for different age groups. Affective disorders are classified as either primary or secondary, 10 depending on whether or not the individual had a preexisting psychiatric disorder. 11 Carlson and Cantwell 5 have recently shown that this dichotomy may also be a useful one for childhood depression. Another familiar classification employs the unipolar—bipolar dichotomy. 12,13 The endogenous-reactive classification offers a third, albeit controversial, view of categorizing depressive disorders. 11 Malmquist's 14 classification of depression has as its basis an association with organic disease, deprivation syndrome, difficulty with individuation, latency type, or adolescent types. Currently, affective disorders are considered to comprise a heterogenous group in adults. All of the preceding classification schemes have some 15–26 degree of validation behind them from family studies, natural history studies, biologic correlates, and responses to various types of treatment. In this paper, we discuss the etiology and treatment of childhood depression from both biologic and psychologic perspectives.
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