Recurrent Phenomenon Research Articles

Seed Hardening: A Way to Tolerate Against Abiotic Stress in Rainfed Areas

Pre-sowing hardening or priming of seeds is one of the best methods for altering the biochemical and physiological process of seeds for favourable condition to induce drought tolerance in emerging seedlings. The recurrent phenomenon in rainfed areas i.e. soil moisture stress immediately after sowing affects seeds germination and their establishment. Under sub-optimal environmental conditions like rainfed farming, poor seed germination followed by poor field establishment is a common phenomenon. Seed hardening enables seedlings to survive this early moisture stress. hydration of seeds for short term before planting greatly benefits stand establishment along with the uses of chemicals like potassium or sodium phosphate would give additional advantage. It is defined as the process of soaking seeds in chemical solution for specified time and then drying to induce tolerance to drought. Various seed priming/hardening techniques have been developed including hydro-priming, halo-priming, osmo-priming and hormonal priming. Micronutrient seed treatments, which include seed priming and seed coating, are an attractive and easy alternative. Seed hardening promotes early establishment provides more strengthen to plant and it became competitive against infections and diseases is related to gene regulation and expression under stress conditions. The discovery of plant hormones in the 1920s underlined the crucial role of these compounds in seed desiccation tolerance, reserve mobilization, as well as cell division and cell elongation occurring during germination. The seed hardening is considered as low cost technology and is the most important requirement for pre-monsoon sowing. Seed hardening offer an attractive option for resource poor farmers. During seed hardening, seeds are subjected to partial hydration followed by dehydration before sowing.

Rare and common manifestations of COVID-19 in children.

IntroductionIt has been almost 2 years since the first reports on cutaneous manifestations of COVID‐19. Those reported in children are different and include macular, papular, lichenoid, vesicular, urticarial, and vascular morphologies, among others. The prognosis of isolated cutaneous involvement in COVID‐19 in children is usually self‐limiting but the extreme variety of clinical presentations complicates the clinical approach.MethodsNumerous reviews have been systematically drafted and edited giving the clinicians a future direction for skin presentations during pandemics.Results and DiscussionHereby we report the rare and common manifestations of COVID‐19 in children and question the recurrence phenomena and age‐related distribution of the eruptions.

Older Persons Displaying Parkinsonian Gait: Prediction and Explanation of the Recurrent Falling Phenomenon and Its Related Poor Prognosis

Introduction: Parkinsonian gait in older persons is a major risk factor for recurrent falling. This prospective, longitudinal study (named EVAMAR-AGEX) aimed to validate the threshold value of two or more falls per year for distinguishing non-recurrent (NRF) from recurrent fallers (RF), to explore predictive factors for recurrent falling, and to identify factors which underlie the transition of patients from NRF to RF. The study took place over 2 years, with an intermediate analysis at 1 year of follow-up. Herein, we report results after 2 years of follow-up. Methods: Participants over the age of 65, diagnosed with parkinsonian gait, were followed over the course of 2 years. Induced parkinsonian syndrome and uncontrolled orthostatic hypotension were excluded. Assessments of motor, visual, and cognitive functions were carried out during visits at baseline. Between visits at 12 and 24 months of follow-up, data were collected by phone call every 2 months (falls, traumatic falls, hospitalizations, cognitive fluctuations, delirium, and mortality). Odds ratios (ORs) for a panel of predictive factors for recurrent falling were established using a Bayesian model. Results: Sixty-six of the 79 initially enrolled participants progressed to the second year of the study, with a mean age of 80.57 (SD 6.3), 56% male, presenting parkinsonian gait (53% Parkinson’s disease, 15% atypical neurodegenerative parkinsonism, 21% vascular parkinsonism, and 11% diffuse Lewy body disease). At 2 years of follow-up, 67% were RF. Univariate analysis revealed a previous history of falls to be the most significant predictive factor of recurrent falls (OR 13.16, credibility interval [CrI] [95%] 4.04–53.73), and this was reinforced at 2 years of follow-up compared to the intermediate 1-year analysis (OR 11.73, CrI [95%] 4.33–35.28). Multivariate analysis confirmed a previous history of falls (OR 13.20, CrI [95%] 3.29–72.08) and abnormal posture (OR 3.59, CrI [95%] 1.37–11.26) to be predictive factors for recurrent falling. Cognitive decline and fluctuating cognition were associated with the transition from NRF to RF (−3.5 MMSE points for participants transitioning from NRF to RF). Conclusion: Within this population of older persons presenting parkinsonian gait, a previous history of falls and abnormal posture may be used to easily identify individuals at risk of recurrent falls. Cognitive decline and fluctuations may underlie the transition of NRF to RF.

Investigation of the effect of bars on the properties of spiral galaxies: a multivariate statistical study

Subjective classification of spiral galaxies is not sufficient for studying the effect of bars on their physical characteristics. In reality the problem is to comprehend the complex correlations in a multivariate parametric space. Multivariate tools are the best ones for understanding this complex correlation. In this work an objective classification of a large set (26,089) of spiral galaxies was compiled as a value added galaxy catalogue from sdss DR 15 virtual data archive. Initially for dimensionality reduction, Independent Component Analysis is performed to determine a set of Independent Components that are linear combinations of 48 observed features (namely ionized lines, Lick indices, photometric and morphological properties). Subsequently a K-means cluster analysis is carried out on the basis of the 14 best chosen Independent Components to obtain 12 distinct homogeneous groups of spiral galaxies. Amongst these, 3 groups are the oldest ones (1.6 Gyr − 5.9 Gyr), while 5 groups fall in the medium aged category (1.4 Gyr − 1.6 Gyr), 2 groups consist of only unbarred spirals, 1 group is the youngest one and the remaining one is an outlier. In many groups there are clear indication of recurrent bar formation phenomena which is consistent with few previous simulation works. In order to study the robustness of the clusters with respect to the method of clustering, a second method of clustering by Gaussian Mixture Modeling Method (GMMBC) is applied.

When the student is the ‘problem’ and the teacher is not the solution: Teacher professional identity in an era of accountability and personalized instruction

Teachers face multiple and often conflicting demands that impact their work and, concomitantly, their professional identities. This article explores teacher professional identity by looking at ways in which teachers construct their arenas of responsibility and their perceived agency within these arenas, against the backdrop of a policy environment demanding both accountability and personalization. Unlike most studies of teacher identity, which rely predominantly upon interview data, the current study features data from teacher in-school workgroup conversations, and in particular examines the ways in which teachers in Israeli primary schools consult with one another about individual students. Recurrent phenomena that appeared in the majority of the 21 cases include: using therapeutic language to describe student ; shifting blame/responsibility to parents ; delineating areas of responsibility ; presenting themselves as empathetic to the student ; and other teachers offering details about student's schooling history or home life . Analysis of a focal case illustrates these phenomena and probes their functions. Key findings include reduction of teachers' responsibility to be commensurate with their perceived diminished agency, alongside general concern for their students' well-being. Implications for policy and practice are discussed.

What Does Disease Progression Look Like in Ulcerative Colitis, and How Might It Be Prevented?

Ulcerative colitis (UC) has been characterized by inflammation limited to the mucosa. Although sustained and durable remission has been associated with mucosal healing, the recurrent phenomenon of persistent clinical disease activity despite mucosal healing has been observed in clinical practice and across pivotal trials. Over time, UC appears to confer an increased risk of progression, defined as changes of disease phenotype; adverse transmural effects on the bowel wall; increased risk of neoplasia development; worsening colorectal function; and increased risk of colectomy, hospitalizations, and other extraintestinal comorbidities. Although the treatment paradigm for Crohn's disease has shifted toward early aggressive intervention to prevent disease progression and irreversible bowel damage, such urgency in efforts to halt disease progression in UC have been largely overlooked. This review summarizes the multiple facets of UC contributing to a modified perception of the disease as a progressive one. We propose further study of the natural history and priorities for further treatment goals that include these considerations.

Effects of second responder programs on repeat incidents of family abuse:An updated systematic review and meta-analysis.

Effects of second responder programs on repeat incidents of family abuse:An updated systematic review and meta-analysis.

Monitoring Lodging Extents of Maize Crop Using Multitemporal GF-1 Images

Maize crop lodging is a recurrent phenomenon which results in significant reduction of grain yield and quality in addition to the impediment of mechanical harvesting. The large-scale monitoring of maize crop lodging is important for production policy adjustment and agricultural insurance compensation. In this article, we derived a variety of features from multitemporal GaoFen-1 (GF-1) images before and after maize crop lodging. We screened the most sensitive features of the spectrum, texture, and vegetation index to monitor maize crop lodging. The recursive feature elimination method based on cross-validation and mutual information were compared to obtain the optimal feature combination for monitoring the lodging extents of maize crop. The random forest classifier was used to classify the lodging extents. The results showed that the most sensitive features of the spectrum, texture, and vegetation indices of lodging extents included the difference of reflectance in blue, green, and red bands, the difference of normalized difference vegetation index, the difference of ratio vegetation index, the difference of enhanced vegetation index difference, the difference of mean value of blue band, the difference of mean value of green band, and the difference of mean value of red band. The total accuracy of lodging extents classification was 87.50%, and the Kappa coefficient was 0.83 for testing samples. Based on multiple features derived from GF-1 images before and after lodging, the lodging extents of maize crop can be monitored on a large scale.

Influence of perturbation amplitude and perturbation frequency on Fermi-Pasta-Ulam-Tsingou recurrence phenomenon

Fermi-Pasta-Ulam-Tsingou recurrence (FPUT) phenomenon refers to the property of a multimode nonlinear system returning to the initial states after complex stages of evolution. The FPUT recurrence phenomenon closely links with modulation instability (MI) by employing the perturbed continuous waves as the initial condition. When the perturbation frequency is located inside the MI spectra, then the perturbed CWs are unstable and the perturbations will grow up with evolution. This nonlinear MI evolution results in the FPUT phenomenon. In this work, we explore in detail the effects of perturbation amplitude and perturbation frequency on the FPUT recurrence phenomena numerically, which has never been studied systematically, to the best of our knowledge. Using the results of our studies, we find that the perturbation amplitude can significantly affect the FPUT phenomenon. Firstly, the number of FPUT cycles is very sensitive to the perturbation amplitude. Large (small) perturbation amplitude can result in much more (much less) FPUT cycles. Secondly, very irregular (regular) FPUT wave evolution together with the corresponding spectra evolution can be observed at relatively large (small) values of perturbation amplitude, where the unequal (equal) distances are observed between adjacent maximum wave amplitudes spatially in the background of optical fibers. In contrast, the effects of perturbation frequency on the FPUT cycles are relatively minor, and the maximum FPUT cycles are observed at perturbation frequencies around the optimal modulation frequency generating the peak MI gain. However, the perturbation frequency can drastically affect the number of high-order sidebands excited at the distances of periodic maximum wave amplitude formation. We find that larger perturbation frequency leads to much fewer high-order sidebands. According to our studies, for observing FPUT conveniently and observing more FPUT cycles, the perturbation amplitude of the input signal should be as large as possible and the perturbation frequency should be around the optimum modulation frequency. We should also emphasize that the large perturbation amplitude results in irregular FPUT patterns with unequal distances between adjacent maximum wave amplitude formations spatially in the background of optical fibers, and large perturbation frequency results in much less high-order sidebands. Our results will provide very helpful information for the FPUT observation in experiment, and should arouse the interest of the readers in nonlinear physics.

PEREGRINA DA LOUCURA: IMIGRAÇÃO E RESISTÊNCIA NO CONTO “SÓ VIM TELEFONAR”, DE GABRIEL GARCÍA MÁRQUEZ

The present work is a literary analysis of the short story “I only came to use the phone”, which is part of the book named Strange Pilgrims written by Gabriel García Márquez. Through it, we analyze the Latin Americanity and pilgrimage themes, as well as how the intertwining of these factors impels María de la Luz Cervantes, the main character, to experience sorrows and misfortunes typical of the unusual which makes up the magical realism which is the literary genre that shapes the narrative. To this end, we undertake an analysis of the historical context of Latin America regarding the themes of immigration, exile, dictatorships etc., recurrent phenomena in the history of the continent and which dialogue directly with the analyzed short story, this overview allows us to clarify both why immigration is a problem in Latin America and what the giving image of the continent is.

Effects of atmospheric discharges on wind farms performance: a review study

One of the factors that influence the energy projects’ performance is the atmospheric conditions. Atmospheric discharges are a recurrent and natural phenomenon, that for the energy sector, represent a risk for the system functioning due to the possibility of damage to the equipment or indirect impacts, such as fires and transmission system shutdown, interrupting the energy supply, and causing socioenvironmental and economic impacts. This article analyzed the effects of atmospheric discharges on tall structures of energy projects performance, namely on wind farms. For that purpose, a systematic literature review was developed, and as complementary data some examples of Brazilian Environmental Impact Assessments of new wind farms projects were verified, to demonstrate the need to consider this parameter on the energy projects assessment. Thus, this review showed that better-quality information about atmospheric discharges, as main causes of the breakdowns and factors which influence the intensity and their geographical location, is important to prepare preventive maintenance plans in the short and long term. Moreover, the environmental studies of new energy projects do not consider this phenomenon as an external factor and their effects, such as the possible conflicts between the responsible enterprise and the affected population.

PERIODIC ILLNESS AS A POST-TRAUMATIC STRESS DISORDER / ՊԱՐԲԵՐԱԿԱՆ ՀԻՎԱՆԴՈՒԹՅՈՒՆԸ ՈՐՊԵՍ ՀԵՏՏՐԱՎՄԱՏԻԿ ՍԹՐԵՍԱՅԻՆ ԽԱՆԳԱՐՈՒՄ

Periodic disease, carrying ethnic character, has not been fully studied from historical and regional perspective. It is known that the descendants of people overlived the genocide mostly are suffering from this disease. The clinical picture of periodic disease is somatized disorder, which is expressed by the symptoms of post-traumatic stress disorder such as flashback recurrent phenomenon, dissipative and conversion disorders. The specific features of the patient’s personality profile during the interscholastic period prove the psychosomatic nature of the disease.

Recurrence in the dynamics of meromorphic correspondences and holomorphic semigroups

This paper studies recurrence phenomena in iterative holomorphic dynamics of certain multi-valued maps. In particular, we prove an analogue of the Poincare recurrence theorem for meromorphic correspondences with respect to certain dynamically interesting measures associated with them. Meromorphic correspondences present a significant measure-theoretic obstacle: the image of a Borel set under a meromorphic correspondence need not be Borel. We manage this issue using the Measurable Projection Theorem, which is an aspect of descriptive set theory. We also prove a result concerning invariance properties of the supports of the measures mentioned.

Pan-Genomic Sequencing Reveals Actionable CDKN2A/2B Deletions and Kataegis in Anaplastic Thyroid Carcinoma.

Simple SummaryAnaplastic thyroid carcinoma (ATC) is a tumor with exceedingly high mortality rates, and current treatment options are very limited once the disease has spread beyond the thyroid gland. Most of what we know of ATCs from a genetic standpoint is based upon previous analyses in which limited DNA segments are sequenced, and little is known about the so-called non-coding DNA regions. To identify novel genetic mechanisms of potential therapeutic use, we sequenced the entire genome of eight ATC cases and corresponding normal tissues. We found a recurrent deletion of two neighboring genes responsible for inhibiting cell division, and these findings may be of clinical interest as there are specific drugs available for tumors with this gene aberration. We also found regional aggregations of mutations in specific clusters, a phenomenon entitled “kataegis”, which in turn could be therapeutically relevant.Anaplastic thyroid carcinoma (ATC) is a lethal malignancy characterized by poor response to conventional therapies. Whole-genome sequencing (WGS) analyses of this tumor type are limited, and we therefore interrogated eight ATCs using WGS and RNA sequencing. Five out of eight cases (63%) displayed cyclin-dependent kinase inhibitor 2A (CDKN2A) abnormalities, either copy number loss (n = 4) or truncating mutations (n = 1). All four cases with loss of the CDKN2A locus (encoding p16 and p14arf) also exhibited loss of the neighboring CDKN2B gene (encoding p15ink4b), and displayed reduced CDKN2A/2B mRNA levels. Mutations in established ATC-related genes were observed, including TP53, BRAF, ARID1A, and RB1, and overrepresentation of mutations were also noted in 13 additional cancer genes. One of the more predominant mutational signatures was intimately coupled to the activity of Apolipoprotein B mRNA-editing enzyme, the catalytic polypeptide-like (APOBEC) family of cytidine deaminases implied in kataegis, a focal hypermutation phenotype, which was observed in 4/8 (50%) cases. We corroborate the roles of CDKN2A/2B in ATC development and identify kataegis as a recurrent phenomenon. Our findings pinpoint clinically relevant alterations, which may indicate response to CDK inhibitors, and focal hypermutational phenotypes that may be coupled to improved responses using immune checkpoint inhibitors.

Tibia hemimelia in a patient with CHARGE syndrome: A rare but recurrent phenomenon.

Tibia hemimelia in a patient with CHARGE syndrome: A rare but recurrent phenomenon.

Spatiotemporal Characteristics and Trends of Meteorological Droughts in the Wadi Mina Basin, Northwest Algeria

Drought has become a recurrent phenomenon in Algeria in the last few decades. Significant drought conditions were observed during the late 1980s and late 1990s. The agricultural sector and water resources have been under severe constraints from the recurrent droughts. In this study, spatial and temporal dimensions of meteorological droughts in the Wadi Mina basin (4900 km2) were investigated to assess vulnerability. The Standardized Precipitation Index (SPI) method and GIS were used to detail temporal and geographical variations in drought based on monthly records for the period 1970–2010 at 16 rainfall stations located in the Wadi Mina basin. Trends in annual SPI for stations in the basin were analyzed using the Mann–Kendall test and Sen’s slope estimator. Results showed that the SPI was able to detect historical droughts in 1982/83, 1983/84, 1989/90, 1992/93, 1993/94, 1996/97, 1998/99, 1999/00, 2004/05 and 2006/07. Wet years were observed in 1971/72, 1972/73, 1995/96, 2008/09 and 2009/10. Six out of 16 stations had significant decreasing precipitation trends (at 95% confidence), whereas no stations had significant increasing precipitation trends. Based on these findings, measures to ameliorate and mitigate the effects of droughts, especially the dominant intensity types, on the people, community and environment are suggested.

An Anti-EGFR/anti- HER2 Bispecific Antibody with Enhanced Antitumor Activity Against Acquired Gefitinib-Resistant NSCLC Cells.

Acquired resistance to epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) is a recurrent phenomenon during clinical therapy of non-small-cell lung cancer (NSCLC). Studies have shown that HER2 is a key factor contributing to drug resistance in a variety of cancers. Furthermore, we have observed that HER2 is overexpressed in PC-9 NSCLC cells with acquired gefitinib-resistance (PC-9/GR) as compared to that in PC-9 cells. We hypothesized that blocking both EGFR and HER2 may serve as a potential strategy for the treatment of NSCLC with acquired gefitinib-resistance. To target both EGFR and HER2 simultaneously, we developed a bispecific antibody HECrossMAb, which was derived from a humanized Cetuximab and Trastuzumab. The binding affinity of HECrossMAb for EGFR and HER2 was measured using an enzyme-linked immunosorbent assay. The MTT assay was used to determine the effect of HECrossMAb on the proliferation of PC-9 and PC-9/GR cells in vitro. Finally, the effect of HECrossMAb on PI3K/AKT signaling and associated transcription factors was measured using western blot analysis. Our results showed that HECrossMAb exerts enhanced cytotoxicity in both PC-9 and PC-9/GR cells by inhibiting the activation of PI3K/AKT signaling and expression of relevant transcription factors such as AEG-1, c-Myc, and c-Fos. Our results suggest that HECrossMAb may function as a potential therapeutic agent for treating NSCLC overexpressing EGFR and HER2.

Clinical and Biomechanical Progression after Ankle Joint Distraction in a Young Adolescent Patient with Haemophilia

Ankle joint distraction (AJD) has been described to be a valuable joint-sparing alternative to arthrodesis or arthroplasty; however, clinical endpoints associated to this surgical intervention are lacking. The current case report describes clinical and biomechanical outcome measures of ankle joint distraction in a 14-year-old patient with severe haemophilia A. Because of persistent and incapacitating pain and the poor response to conservative and invasive treatment options, ankle joint distraction was performed in this 14-year-old patient using an external fixator encompassing two Ilizarov full rings in the tibia and a foot ring fixed to the foot by four K-wires. State-of-the-art medical imaging and non-invasive skin marker-based 3D multi-segment foot modelling were performed in a pre- and post-operative stage. From a structural viewpoint, this AJD was a success since it improved and stabilised the osteo-cartilaginous lesions of the ankle. Biomechanical outcome measures associated with the 18-month follow-up were found to be suboptimal, showing an early plantarflexion pattern at the ankle joint during midstance and a tendency towards increased power absorption at the midfoot with peak power absorption being almost two times higher when compared to boys of the same age. From a functional viewpoint, we observed a clear reduction in the patients’ physical activities until one year after AJD. Despite these functional and structural improvements, recurrent painful phenomena, including the development of a complex regional pain syndrome (CRPS) and a stress fracture of the third metatarsal bone, were observed which are probably related with the development of recurrent subchondral oedema.

A Postoperative Phenomenon of Percutaneous Endoscopic Lumbar Discectomy: Rebound Pain.

ObjectiveAfter percutaneous endoscopic lumbar discectomy (PELD), most patients with lumbar disc herniation (LDH) experience relief from the typical symptoms of low back and leg pain. However, for a small number of patients, these symptoms are relieved immediately after surgery but aggravated soon after, and then relieved after short‐term full rest or conservative treatment. The aim of the study was to demonstrate this short‐term recurrent phenomenon, termed rebound pain.MethodsA retrospective study was conducted on 144 patients who underwent single‐segment PELD from May 2017 to June 2020. Postoperative patients were divided into a rebound pain group and a non‐rebound pain group. For the former group, general information, symptom characteristics and visual analogue score (VAS) changes in rebound pain were summarized. For both groups, postoperative efficacy was evaluated by recent VAS of low back and leg pain in the remission stage, the Oswestry disability index (ODI) and the modified MacNab criteria at the last follow‐up. Logistic regression analysis was used to identify predictors for rebound pain.ResultsThe VAS and ODI exhibited significant improvements at the last follow‐up of average 15.4 months (P < 0.001). The successful outcomes according to the modified MacNab criteria reached 94.4%. A total of 15 patients (10.4%) experienced rebound pain. The typical feature was pain that usually began within 1 month after surgery and lasted for less than 1 month. The symptoms were mainly leg pain with or without low back pain. The range of pain was equal to or less than that before surgery. The symptoms were relieved after conservative treatment. In logistic regression model, postoperative return‐to‐work time > 45 days was found as a protective factor for rebound pain (p = 0.031).ConclusionAlthough rebound pain with multiple characteristics and a short duration had no significant effect on long‐term postoperative efficacy, its high incidence often caused unnecessary concern in both patients and doctors. As a result, careful differentiation of rebound pain from other postoperative complications is needed.

Single Independent Autopolyploidization Events From Distinct Diploid Gene Pools and Residual Sexuality Support Range Expansion of Locally Adapted Tetraploid Genotypes in a South American Grass.

Polyploidy plays a major role in plant evolution. The establishment of new polyploids is often a consequence of a single or few successful polyploidization events occurring within a species’ evolutionary trajectory. New polyploid lineages can play different roles in plant diversification and go through several evolutionary stages influenced by biotic and abiotic constraints and characterized by extensive genetic changes. The study of such changes has been crucial for understanding polyploid evolution. Here, we use the multiploid-species Paspalum intermedium to study population-level genetic and morphological variation and ecological differentiation in polyploids. Using flow cytometry, amplified fragment length polymorphism (AFLP) genetic markers, environmental variables, and morphological data, we assessed variations in ploidy, reproductive modes, and the genetic composition in 35 natural populations of P. intermedium along a latitudinal gradient in South America. Our analyses show that apomictic auto-tetraploids are of multiple independent origin. While overall genetic variation was higher in diploids, both diploids and tetraploids showed significant variation within and among populations. The spatial distribution of genetic variation provides evidence for a primary origin of the contact zone between diploids and tetraploids and further supports the hypothesis of geographic displacement between cytotypes. In addition, a strong link between the ecological differentiation of cytotypes and spatial distribution of genetic variation was observed. Overall, the results indicate that polyploidization in P. intermedium is a recurrent phenomenon associated to a shift in reproductive mode and that multiple polyploid lineages from genetically divergent diploids contributed to the successful establishment of local polyploid populations and dispersal into new environments.