To observe the clinical efficacy of acupoint injection plus medication in treating recurrent facial dermatitis (RFD). Fifty-eight patients with RFD were randomized into a treatment group and a control group, 29 in each. The treatment group was intervened by acupoint injection with BCG-PSN plus oral administration of Fexofenadine Hydrochloride, and the control group was by Fexofenadine Hydrochloride only. The clinical efficacies were compared between the two groups, and a follow-up study was conducted to investigate the recurrence rate. The total effective rate was 96.6% in the treatment group versus 65.5% in the control group, and the difference was statistically significant (P<0.01). Of the cured and improved patients in the treatment group, the recurrence rates were 10.7%, 25.0%, and 32.1% respectively 3 months, 6 months, and 12 months after treatment, versus 31.6%, 36.8%, and 73.7% in the control group, and the differences were statistically significant (P<0.05). Acupoint injection plus medication is an effective method in treating RFD.