You have accessJournal of UrologyKidney Cancer: Basic Research & Pathophysiology I1 Apr 2016MP71-04 SINGLE NUCLEOTIDE POLYMORPHISMS ASSOCIATED WITH RECURRENCE AFTER TREATMENT OF NON-METASTATIC RENAL CELL CARCINOMA Justin Gregg, Zachary Glaser, Curran Emeruwa, Johnson Wong, Christopher Johnson, Arturo Holmes, Loren Lipworth, Peter Clark, and Todd Edwards Justin GreggJustin Gregg More articles by this author , Zachary GlaserZachary Glaser More articles by this author , Curran EmeruwaCurran Emeruwa More articles by this author , Johnson WongJohnson Wong More articles by this author , Christopher JohnsonChristopher Johnson More articles by this author , Arturo HolmesArturo Holmes More articles by this author , Loren LipworthLoren Lipworth More articles by this author , Peter ClarkPeter Clark More articles by this author , and Todd EdwardsTodd Edwards More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2016.02.1450AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES A number of factors are known to be associated with the diagnosis of renal cell carcinoma (RCC), including age, smoking, body mass index (BMI), and hypertension. Single nucleotide polymorphisms (SNPs) have previously been shown to be associated with the diagnosis and prognosis of RCC and the aforementioned risk factors. We aimed to determine if these SNPs were associated with disease recurrence after treatment of RCC. METHODS Patients at our institution who were previously genotyped as part of a multi-institutional genome-wide association study were eligible. Those who had been treated for RCC and did not have metastatic disease at time of presentation or surgery were included. SNPs of interest were chosen based on published association with established RCC risk factors and inclusion in the previously used genotyping platform (43 SNPs, total). Demographic, pathologic, and recurrence information were extracted using validated algorithms and manual review from the de-identified electronic health record. SNPs of interest were tested for their association with local or distant RCC recurrence using separate multivariable logistic regression models for each SNP adjusting for tumor size, stage, histology, Fuhrman grade, and margin status. RESULTS A total of 308 patients were included in the study. Median follow-up time was 3.5 years (STD 3.8) for the 303 patients with available data. Among these, 241/308 (78.2%) had all data points available. Forty out of 241 patients (16.6%) had disease recurrence during follow-up. Tumor characteristics included 195/241 (80.9%) clear cell RCCs, 160 (66.4%) with T1 disease, 44 (18.3%) with Fuhrman grade 1 pathology, 12 (5.0%) with positive margins, and average tumor size of 5.2cm. Of the tested variables, only tumor stage was associated with disease recurrence in all 43 multivariable models (p<0.01 for all). SNPs rs2237892-T (p=0.02) and rs12983273-T (p=0.03) were associated with recurrence (Table). CONCLUSIONS Two SNPs previously associated with BMI (rs2237892-T) or RCC survival (rs12983273-T) are associated with RCC recurrence. Further studies including larger patient populations, time-dependent analyses and additional recurrence-related covariates are warranted. © 2016FiguresReferencesRelatedDetails Volume 195Issue 4SApril 2016Page: e916 Advertisement Copyright & Permissions© 2016MetricsAuthor Information Justin Gregg More articles by this author Zachary Glaser More articles by this author Curran Emeruwa More articles by this author Johnson Wong More articles by this author Christopher Johnson More articles by this author Arturo Holmes More articles by this author Loren Lipworth More articles by this author Peter Clark More articles by this author Todd Edwards More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...