Recovery Of Rate Research Articles

Influence of water of negative oxidation-reduction potential with hydrogen saturation on kidney function in rats

Objective. To study the effect of water load of negative redox potential with hydrogen saturation on renal function in comparison with induced diuresis with water of negative redox potential without hydrogen saturation.Material and methods. In experiments on 60 male white-nonlinear rats weighing 0.16-0.18 kg, the effect of loading with ordinary tap water (redox potential 90.4 ± 1.45 mV), water of negative redox potential without saturation with hydrogen (redox potential - 304.5 ± 4.79 mV) and water of negative redox potential with hydrogen saturation 1.0 - 1.2 ppm and redox potential -297.3 ± 5.27 mV. Used: experimental, physiological, biochemical, chemical, physicochemical, statistical research methods.Results. Under water load of negative redox potential with hydrogen saturation in comparison with induced diuresis of negative redox potential with the use of microhydrin, there was no inhibition of glomerular filtration, filtration fraction and proximal reabsorption of sodium ions, change restorative potential of urine. These changes are explained by the lack of activation of the dysregulatory mechanism of basal vascular tone of the renal cortex under conditions of water load of negative redox potential with hydrogen saturation.Conclusion. Water loading of negative redox potential with hydrogen saturation in comparison with induced diuresis of negative redox potential without hydrogen saturation causes recovery of glomerular filtration rate, filtration fraction and proximal reabsorption of sodium ions, due to the lack of activation of the mechanism of basal vascular tone of the renal cortical substance, due to the high permeability of molecular hydrogen and uniform delivery of electrons to all organs and tissues.

Is there a relationship between heart rate recovery and blood pressure in white coat hypertension?

Aim Increasing evidence suggests that autonomic dysfunction may be involved in the etiology of white coat hypertension (WCH). The aim of this study was to evaluate cardiac autonomic function by using heart rate recovery (HRR) indices in patients with WCH classified according to their circadian rhythm type of blood pressure (BP).Material and methods This cross-sectional study included 120 participants over the age of 18 yrs, including 50 patients diagnosed with WCH and 70 healthy controls with normal in- and out-of-office BP and without any known disease. Circadian rhythm types, i.e., dippers and non-dippers, were identified using ambulatory BP monitoring. The HRR indices were calculated by subtracting the 1st-minute (HRR1), 2nd-minute (HRR2), and 3rd-minute (HRR3) heart rates from the maximal heart rate recorded during stress testing.Results The lesser decline in nighttime BP (6.4±2.14 and 13.3±2.2 mmHg, respectively; p<0.001) and the smaller mean HRR1 (25.5±3.0 and 30.3±3.1 beats / min, respectively; p<0.001) were evident in WCH non-dippers compared to WCH dippers. Linear regression analysis showed that HRR1 (β±SE=0.43±0.11; p<0.001) and diastolic BP at maximum exercise (β±SE=0.14±0.07; p=0.040) are independent risk factors for the blunted decline in nighttime BP.Conclusion Delayed recovery of heart rate after an exercise stress test is associated with non-dipper type of circadian rhythm of BP. This was more pronounced in WCH patients, and these patients are at risk of autonomic dysfunction.

The influence to the sports horses performance traits of the compound feeds from the heat-treated grain insertion in the diet

The efficiency of the horse, high sports results and the effectiveness of recovery after stress, are largely dependent on the characteristics of the organization of nutrition and diet. The comparative assessment of the performance traits and the speed of recovery after workloads in the Oryol trotterhorseis presented in this work. Six horses were each fed diets of hay and cereal grains (HG), hay and combination of cereal grains and compound feed (HGM) in a 2 x 2 Latin-square design study. The performance was assessed by heart rate (HR) indicators using a Polar M400 monitor with an H10 heart rate sensor. Recovery of the heart rate to 80 beats / min after medium work (the average heart rate to 120 beats / min) at HG and HGM horses had no statistically significant differences. Recovery of heart rate to 60 beats / min in the HGM was significantly faster (P <0.05) than in the HG. Under intense workloads (average heart rate above 120 beats / min, or at least 5% of work at a heart rate of 180 beats / min or more), the HGM showed a significant (P <0.05) faster recovery of heart rate values after work than in horses HG. In the course of the study, it was also found that the use of partial replacement of grain concentrates with specialized feeds allows us to reduce the volume of the ration and the total amount of concentrates without changing the structure of the ration.

RapidHRV: an open-source toolbox for extracting heart rate and heart rate variability.

Heart rate and heart rate variability have enabled insight into a myriad of psychophysiological phenomena. There is now an influx of research attempting using these metrics within both laboratory settings (typically derived through electrocardiography or pulse oximetry) and ecologically-rich contexts (via wearable photoplethysmography, i.e., smartwatches). However, these signals can be prone to artifacts and a low signal to noise ratio, which traditionally are detected and removed through visual inspection. Here, we developed an open-source Python package, RapidHRV, dedicated to the preprocessing, analysis, and visualization of heart rate and heart rate variability. Each of these modules can be executed with one line of code and includes automated cleaning. In simulated data, RapidHRV demonstrated excellent recovery of heart rate across most levels of noise (>=10 dB) and moderate-to-excellent recovery of heart rate variability even at relatively low signal to noise ratios (>=20 dB) and sampling rates (>=20 Hz). Validation in real datasets shows good-to-excellent recovery of heart rate and heart rate variability in electrocardiography and finger photoplethysmography recordings. Validation in wrist photoplethysmography demonstrated RapidHRV estimations were sensitive to heart rate and its variability under low motion conditions, but estimates were less stable under higher movement settings.

The features of the USSR population reproduction in 1920–1930 in the demographic stability parameters

The 1932–1933 Holodomor genocide caused a significant reduction of the population and distorted the main parameters of the country’s demographic stability. To analyze the changes in the population by the longitudinal analysis method, the survival rates are calculated for age groups of the population in the intercensal periods. Calculations based on the data of 1926 and 1939 censuses show substantial inconsistencies in the survival rate for five female age groups within the range of 33-57 years old. Despite the 1932–1933 demographic catastrophe and taking into account the natural mortality before and after the Holodomor, the number of people in these age categories changed slightly and even increased for the 43-47 category. The authors prove that migration in the intercensal period couldn’t have caused such growth, and the calculated coefficients confirm the questionable quality of the 1939 census. The paper reveals that the first stage of demographic transition should have been in 1932–1933, yet historical-political and socio-economic conditions of demographic reproduction aggravated considerably in early 1930. The recovery of the high birth rate in 1937–1938 shows that the first stage of demographic transition wasn’t finalized. Calculation of the number of women in the most active childbirth age and analysis of birth rate for 1924–1929 shows that in 1930–1933, the birth rate should have increased. The calculated indirect demographic losses account 310,000-430,000 annually for 1930, 1931, 1937, and 1938, and from 630,000 to 1 million for 1932–1936. Such insignificant volume of indirect losses substantially reduced demographic stability, in the first place of Ukrainian village. The incomplete and questionable nature of demographic data after 1932 does not allow complete reconstruction of the demographic reproduction processes in the USSR in the 1930s. Archive data on the natural movement of the population on lover administrative-territorial levels, current statistical recordings, and recordings of the civil status acts on birth and mortality, etc. can be the perspective sources of demographic information.

Equipment for pulsed gas-and-chemical regeneration of water wells

The development of new methods for the regeneration and recovery of specific flow rate of water intake wells is an urgent task. Based on many years of the experience in well operation, it has been proved that all wells eventually need to be repaired. The main reason for such work is the chemical clogging of the filter and filter zone with different chemical compounds. The average stable operation period of new wells is 2–4 years. Better cleaning of filters and filter zones in water intake wells is achieved using the combination of hydraulic, impulse and vibration attacks with subsequent or concurrent chemical treatment. At this date, none of the integrated approaches enjoys wide application due to some disadvantages. At the Belarusian National Technical University, the pulse-and-chemical regeneration equipment has been designed for water intake wells. The technology involves electrolysis-induced explosion of a hydrogen–oxygen mixture at the well mouth on ground surface, feed of the mixture to a working chamber in the well filter, filling of a chemical reagent in the filter treatment zone and explosion of the reagent medium. The equipment has successfully passed laboratory and field tests.

Impact of Sambo Techniques on Students' Physical Health during the Study in Higher Education Institutions

The article presents the results of the application of sambo techniques to the physical health of student youth in higher education institutions. During the research the following methods were used: analysis and use of data on scientific and methodological literature; pedagogical observation; anthropometry and physiometry; pedagogical experiment and methods that used statistics. The study of body mass index, life index, power index, Robinson index, the time of recovery of heart rate to baseline after 20 squats in 30 sec and, in fact, the level of physical health by the sum of points according to the method proposed by G.L. Apanasenko during the first and second stages (I-II courses of study) showed that one of the ways to improve the level of physical health of student youth is to introduce sambo sports educational classes into the curriculum. This is manifested at the end of the experiment that there was the decrease in number of experimental group (EG) of students with low and below average physical health: in the group of male students by 60%, in the group of female – 47, 4%. The number of male EG students with average and higher than average levels of physical health increased from 16.0 to 76.0%, female students - from 19.1 to 81.5%, which ensured that students were engaged in systematic physical exercises that allowed to improve their level of fitness, physical development, functional state and physical health.

ВПЛИВ ЗАНЯТЬ СПОРТОМ НА ФУНКЦІОНАЛЬНІ МОЖЛИВОСТІ СЕРЦЕВО-СУДИННОЇ СИСТЕМИ ДІВЧАТ 17-21 РОКІВ ПОДІЛЬСЬКОГО РЕГІОНУ

In this article considers the effectiveness of the impact of sports on the functionality of the cardiovascular system of girls 17-21 years old living within the Podolsk region. The function of the cardiovascular system of girls was evaluated by the ability to recover after termination of work (by the parameters of heart rate). Classes cycling and playing sports (performance of muscle work of which is connected with the mixed mode of power supply) and martial arts (performance of muscular work is associated with anaerobic (lactate) mode of power supply) contribute to improvement the functional possibilities of the cardiovascular system. This is manifested by the acceleration of recovery of heart rate after metered physical loads of 1 watts and 2 watts per 1 kg of body weight. The smallest percentage of person with a slow recovery of heart rate were detected among athletes, volleyball players and representatives of complex coordination sports. These individuals are involved in the performing of physical exercise with anaerobic (alactate) processes of metabolism.

Correction to: Analysis on correlation between the heart rate variability and the recovery of heart rate after high intensity intermittent exercise

Correction to: Analysis on correlation between the heart rate variability and the recovery of heart rate after high intensity intermittent exercise

P0647ACUTE KIDNEY INJURY SECONDARY TO SUCROSE CONTAING INTAVENOUS IMMUNOGLOBULIN

Abstract Background and Aims Intravenous immunoglobulins (IVIG) are pooled polyvalent IgG antibodies extracted from the human plasma. While the initial indications were mainly immune deficiency states and some autoimmune diseases, the usage has been widened to include several immune mediated diseases, viral infections, and organ transplant rejection. Stabilizers in IVIG may include sugars, such as sucrose, glucose, or maltose. Sucrose in IVIG preparations may cause acute kidney injury. We report the case of a renal transplant patient who developed acute kidney injury due to sucrose nephropathy following the administration of sucrose containing IVIG. Method Four months after transplantation he was referred to our Hospital for deterioration of kidney function with eGFR (by MDRD formula) of 27ml/min. Cytomegalovirus virus (CMV) PCR turned positive (3300 copies/ml). Cyclosporine levels were high (C2: 2937 ng/ml) and hence, cyclosporine dose was adjusted. Induction therapy with Injection Ganciclovir for 2 weeks, followed by therapeutic dose of oral Valganciclovir was administered for the treatment of CMV infection. Skin examination revealed annular purple patches, suspicious of Kaposi Sarcoma, on the upper limbs. Skin biopsy confirmed the diagnosis. It was planned to give total IVIG of 2 gm/ kg in four daily divided doses. After completion of the second dose, serum creatinine increased to 370 µmol/L. He was clinically asymptomatic, euvolumic, vital signs were stable, and his urine output remained normal and his urinalysis was inactive. Results The ultrasound of the transplant kidney was normal with normal resistivity index. IVIG was stopped. He was well hydrated and underwent ultrasound guided biopsy. The graft biopsy showed acute tubular injury with flattening and vacuolation of tubular epithelial cells. Mitosis indicating tubular regeneration was seen. There was mild focal interstitial inflammation (20%) with mild lymphocytic tubulitis not amounting to graft rejection. Immunohistochemistry for C4d and polyomavirus (BKV) were both negative. The features were most consistent with sucrose induced nephropathy (Figure 1). Subsequent visits showed a decrease in BKV-PCR serum level and eventually undetected serum level of BKV-PCR at follow up about a month later. Conclusion In this paper, we presented a case of a living unrelated kidney transplant recipient who developed BKV nephropathy and developed impaired kidney function. The patient also had new onset diabetes mellitus after kidney transplantation (NODAT) but was otherwise in good general health. Treatment included sucrose containing IVIG. The patient subsequently developed acute kidney injury. The outcome was favorable with recovery of filtration rate to the baseline within 21 days without the need for dialysis. We conclude that the administration of sucrose containing IVIG may lead to acute kidney injury. We recommend the use of sucrose-free IVIG whenever possible. In all cases, caution is required when administrating IVIG.

Analysis of aerobic testing in basketball referees and heart rate recovery time

Abstract The study analyzed the physical conditioning and the time of recovery of the maximum heart rate of 12 international referees being used the test of 20 meters with beep to evaluate the cardiorespiratory conditioning, with the frequency to control the recovery time of the maximum cardiac post test. The majority of the referees obtained a recovery of heart rate greater than 50% in 3 minutes, were those that reached the levels of good to excellent in the table of maximum Vo2. Even with some factors influencing their physical performance most of the referees were able to complete the aerobic test and obtained a good recovery of the heart rate, the others that failed to reach the test goal had the HR recovery in 3 minutes much lower than expected, thus highlighting the association of the maximum VO2 level between good and excellent with the recovery of the heart frequency.

Cardiac myocyte functional and biochemical changes after hypothermic preservation in vitro. Protective effects of storage solutions.

In this study, we evaluated cardiac myocyte viability and function under hypothermic conditions with four types of storage solutions, saline solution, Euro-Collins solution, University of Wisconsin solution, and MCDB 107 medium. Cardiac myocytes were isolated from neonatal rat ventricles by collagenase dispersion and cultured for 4 days with MCDB 107 medium. A total of 12.5 x 10(5) myocytes per culture dish was used and the myocytes were incubated at 4 degrees C for 6, 12, 18, and 24 hours in the various storage solutions. After each incubation time, creatine kinase and lactate dehydrogenase were measured in the storage solutions. The myocytes were then incubated for 24 hours at 37 degrees C to evaluate the recovery of the myocyte beating rate. In the MCDB 107 group (n = 7), the recovery ratio of myocyte beating rate was complete by 12 hours, then decreased to 44.8% of control (beating rate before hypothermic incubation) at 24 hours. The saline, Euro-Collins, and University of Wisconsin groups (n = 7 each) had significantly lower recovery ratios than the MCDB 107 group (at 12 hours: 61.0%, 32.2%, and 48.9%; at 18 hours: 0.0%, 5.5%, and 15.1% of control, respectively). Release of creatine kinase and lactate dehydrogenase in the MCDB 107 group gradually increased and at 24 hours was 143.2 mIU/flask and 486.2 mIU/flask, respectively. However, the saline and University of Wisconsin groups had significantly increased creatine kinase and lactate dehydrogenase values at 24 hours (creatine kinase: 334.6 and 319.6 mIU/flask; lactate dehydrogenase: 821.6 and 654.4 mIU/flask, respectively). The Euro-Collins group showed the greatest increase in both markers (creatine kinase: 1587.5, lactate dehydrogenase: 2106.9 mIU/flask). In summary, saline and University of Wisconsin solutions showed a beneficial effect on recovery of myocyte viability at 12 hours compared with Euro-Collins solution, however MCDB 107 medium had the best overall protective effect on cultured myocytes. Accordingly, alternate hypothermic storage solutions, such as cell-culture medium, may have protective characteristics that are suitable for cardiac preservation.

Analysis on correlation between the heart rate variability and the recovery of heart rate after high intensity intermittent exercise

Analysis on correlation between the heart rate variability and the recovery of heart rate after high intensity intermittent exercise

AEROBIC FITNESS AND TYPE OF RECOVERY INFLUENCE POST-EXERCISE HEART RATE RECOVERY IN YOUNG WOMEN

This study aimed to analyze both influence of aerobic fitness and active recovery in heart rate (HR) reduction after maximum exercise (i.e. maximum incremental test) in untrained young women. Seventeen women were evaluated (23.88 ± 4.85 years), divided by the medium of peak of consumption of oxygen (30.80 mL.kg-1.min-1), in higher or lower aerobic fitness obtained during a maximum incremental test performed on a cycle ergometer. The post-exercise recovery was performed actively and passively, on two randomly non-consecutive days. It was noticed that HR at 6th and from the 6th to 10th min after the passive and active recovery, respectively, was lower in the higher aerobic fitness group, beyond that, the values of %HR reduction from the 6th to 10th min at 6th min after passive and active recovery, respectively, were higher in the higher aerobic fitness group. After active recovery, HR in 8th and 9th min and %HR reduction of the 8th to 10th min were lower and higher, respectively (p<0.05) than passive recovery in the lower aerobic fitness group. In short, the aerobic fitness influenced HR reduction after maximum exercise in untrained young women, mainly, after passive recovery. Besides that, the active recovery showed benefits in HR reduction in lower aerobic fitness group.

Natural and Technogenic Mineral Formation in the Aquifer of the Amur-Tunguska Interfluves

Changes in mineralogical composition occurring in the course of preparation of drinking water in-situ are studied based on the data from the monitoring wells of the Tunguska groundwater intake. Intensive dissolution of feldspars, pyroxenes, siderite, and, to a lesser extent, quartz with the formation of secondary minerals (amorphous silica, clay minerals, and secondary siderite) occur in the aquifer of the Tunguska intake. In addition, solid products of the destruction are formed, including microfragments of minerals, which together with the primary clay, secondary minerals, and oxides and hydroxides of iron and manganese that originated in the process of intralayer oxidation of water, participate in the colmatation of cracks and the slit space of the well filters. Regeneration actions result only in a partial recovery of the specific flow rate of the wells, since the hydrochloric acid used in them leaches only the oxide–hydroxide part of the colmatant, leaving virtually unchanged its aluminosilicate component.

Analysis of the operation timing and effect of anastomosis for 388 cases of laceration of inferior lacrimal canaliculus

Objective To investigate the surgical timing of anastomosis and efficacy of U-type silicone stent implantation for the treatment of laceration of inferior lacrimal canaliculus. Methods From Jan. 2012 to Oct. 2016, the data of 388 eyes of 388 patients with laceration of inferior lacrimal canaliculus were analyzed retrospectively. Age of all cases ranged from 2 to 79 years. There were 314 males (80.9%) and 74 females. All cases underwent double lacrimal canaliculus placement silicone stent implantation under the surgical microscope. The silicone stent was placed for 3 months and followed up for 3 months after removed. Results The difference of efficacy was not statistically significant among different operation time. At the end of follow-up, the cure rate was 78.3%, the recovery of rate was 13.6%, and the inefficiency was 8.1%. Conclusion The surgical timing of anastomosis for lacrimal canaliculus laceration should be choose before the anterior eyelid tissue edema, and it is easier to find the nasal breakage of lacrimal duct. Key words: Laceration, inferior lacrimal canaliculus; Anastomosis; Surgical timing; Stent, silicone, double lacrimal canaliculus placement

Clinical analysis of continuous blood purification in the treatment of severe sepsis in infants

Objective To investigate the clinical efficacy and safety of continuous blood purification (CBP) in the treatment of severe sepsis in infants. Methods A retrospective analysis of 40 infants with severe sepsis treated with CBP was performed at PICU of Hunan Children′s Hospital from January 2014 to July 2017, and 50 infants with severe sepsis who were not treated with CBP at the same period were enrolled as control group.The indicators included blood gas analysis, lactic acid (Lac), blood glucose, electrolytes, blood routine, C-reaction protein (CRP) and procalcitonin (PCT), alanine aminotransferase (ALT) and aspartate aminotransferase (AST), total bilirubin(TB), urea nitrogen (BUN), serum creatinine (Scr) and creatine kinase isoenzyme MB (CK-MB), pediatric critical illness score (PCIS). Results (1) After 3 days of treatment, the recovery of body temperature, heart rate, respiratory rate and blood pressure in CBP group were better than those in the control group, and the differences between two groups were statistically significant(P 0.05). (5) Two cases of thrombocytopenia, 2 cases of femoral vein thrombosis, 2 cases of hypovolemic shock, and 1 case of blood coagulation in filter happened in CBP gruop, all cases had no puncture site infection. Conclusion CBP can improve the vital signs, internal environment, inflammatory reaction and organ function of infants with severe sepsis, and the effect is better than that of traditional methods.The complications of CBP in infants with severe sepsis are relatively large, so we should strictly master the indications of CBP in the treatment of severe sepsis in children. Key words: Continuous blood purification; Severe sepsis; Infants; Clinical efficacy; Safety

Renovación contextual de la distribución temporal del responder

Se ha reportado que en ciertos fenómenos (recuperación espontánea, readquisición, resurgencia y renovación contextual) es posible observar la recuperación de una respuesta previamente extinguida. La renovación contextual, se refiere a la reaparición de una respuesta extinguida que resulta de un cambio de contexto entre la fase de extinción y prueba. El propósito del presente trabajo consistió en evaluar la renovación contextual, atendiendo tanto a la distribución temporal del responder, como a la tasa de respuesta. Se encontró una recuperación de la tasa de respuesta, siendo un resultado consistente con los reportados en el área de renovación contextual. Además, se pudo identificar una renovación de la distribución temporal de respuesta. Los resultados se discuten reconociendo que la tasa y la distribución temporal constituyen dos dimensiones de la ejecución que son moduladas por los cambios de contexto.

Hygienic aspects of physical education and health of schoolchildren

Aim: to analyze the state of physical education in secondary schools of Ukraine and to observe hygienic requirements during physical education lessons. Material: the study was attended by schoolchildren (n=40, age - 12-13 years) and schoolchildren of specialized sports classes (n=40, age - 14-16 years). Studied: the level of physical health; functional state of the respiratory and cardiovascular systems; the state of energy supply of children’s organism; the influence of mobile games on the functional capabilities of the body of children. To study the effects of physical exercises on the development of the muscular system of children, excretion of creatinine with urine was studied. Results: high levels of physical and functional status of young players are noticed. These data are significantly higher than similar data from their peers from non-sports classes. In the course of systematic training and competitions, excretion of creatinine decreases at the end of the season to 0.8 g/l. These changes point to a decrease in energy resources and are consistent with a decrease in the rapid qualities of young players (as a measure of overall physical fitness). In this group of pupils, there were 2-4% lessons in the classes: mostly because of colds. In schoolchildren of ordinary schools, indicators of physical development and functional status were significantly worse. The indicators of the lung capacity were 3500-3800 ml. The distance of 30 m children ran for 5,5±0,4 seconds. The index of the brush dynamometer was 35±1,8 kg. The results of the recovery of the heart rate after the metered loading were from 2 to 3 minutes. There is a shortage of body weight in 12% of schoolchildren. There is an overweight in 1,8% of schoolchildren. Conclusions: in the structure of children’s morbidity a high level of respiratory diseases, gastrointestinal tract, and eyes is allocated. Therefore, when taking physical training, such data should be taken into account. It is also necessary to take into account the level of individual somatic health, which leads to a safe area of intense motor activity.

Tissue Blood Flow in the Digestive Organs of Rats with Acute Pancreatitis after Corvitin Administration

We have investigated the action of quercetin (in a modified form--Corvitin, BCPP, Ukraine) on the rate of blood flow in the pancreas, liver and gastric mucosa of rats with acute pancreatitis (AP) caused by administration of L-arginine. The rate of blood flow was measured by hydrogen clearance method with electrochemical his generation using Polarographs Lr-9 (Czech Republic). During the first 10 days after modelling of AP in these organs it was observed a gradual decrease compared to the intact animals in the rate of blood flow by 42% (P < 0.01) in the pancreas; by 61% (P < 0.001) in the liver and by 64% (P < 0.001) in the gastric mucosa, i.e., the most significant changes occurred in the gastric mucosa, the least--in the tissue of the pancreas. Compared with the control group of animals with modelling acute pancreatitis which during 20 days was administered only saline, application of Corvitin (5 mg/kg, 1 time per day from 11 to 20 days of experiment) in varying degrees promoted to the recovery of the rate of blood flow in all investigated organs: in the pancreas--fully, in the liver--almost entirely and in the gastric mucosa--only partially. Thus, based on obtained results Corvitin can be recommended for partial or complete correction of blood flow disturbances, which arise in the pancreas and other organs of the digestive system in AP. Corvitin can improve the functional state of these organs in the early stages of the disease and accelerate the full restoration of their functions.