Influence of water of negative oxidation-reduction potential with hydrogen saturation on kidney function in rats

Abstract

Objective. To study the effect of water load of negative redox potential with hydrogen saturation on renal function in comparison with induced diuresis with water of negative redox potential without hydrogen saturation.Material and methods. In experiments on 60 male white-nonlinear rats weighing 0.16-0.18 kg, the effect of loading with ordinary tap water (redox potential 90.4 ± 1.45 mV), water of negative redox potential without saturation with hydrogen (redox potential - 304.5 ± 4.79 mV) and water of negative redox potential with hydrogen saturation 1.0 - 1.2 ppm and redox potential -297.3 ± 5.27 mV. Used: experimental, physiological, biochemical, chemical, physicochemical, statistical research methods.Results. Under water load of negative redox potential with hydrogen saturation in comparison with induced diuresis of negative redox potential with the use of microhydrin, there was no inhibition of glomerular filtration, filtration fraction and proximal reabsorption of sodium ions, change restorative potential of urine. These changes are explained by the lack of activation of the dysregulatory mechanism of basal vascular tone of the renal cortex under conditions of water load of negative redox potential with hydrogen saturation.Conclusion. Water loading of negative redox potential with hydrogen saturation in comparison with induced diuresis of negative redox potential without hydrogen saturation causes recovery of glomerular filtration rate, filtration fraction and proximal reabsorption of sodium ions, due to the lack of activation of the mechanism of basal vascular tone of the renal cortical substance, due to the high permeability of molecular hydrogen and uniform delivery of electrons to all organs and tissues.