Recovery Of Morphine Research Articles

Morphine Recovery from a 2-Butanol Extract of Opium Poppy Meal

Morphine Recovery from a 2-Butanol Extract of Opium Poppy Meal

Extraction of Morphine from Poppy Capsules and its Recovery by Ion Exchange

An efficient method for obtaining morphine from domestically grown poppies has been developed. Morphine was completely extracted from dried poppy capsules with water-aturated isobutanol containing 0.23% ammonia. By passage of the extract through a cation exchange resin bed, practically all of the alkaloid was adsorbed. Quantitative elution of morphine from the bed was achieved with dilute aqueous alkali. Crude morphine obtained by precipitation from the neutralized and concentrated eluate could be converted to pharmaceutical grade hydrochloride without difficulty. The overall recovery of morphine was 90%.

CELLS OF NERVOUS SYSTEM IN ACUTE AND IN CHRONIC MORPHINISM

Since 1925 the department of pharmacology at the State University of Iowa has been investigating the effect of morphine on tolerant and nontolerant dogs. During the process of addiction of a large series of dogs for these investigations, three died in convulsions, two while on increasing doses and one after withdrawal of the drug. The tissues from two of the animals, prepared by routine histologic technics, were examined by one of us (E. M. MacE.), with negative results (Plant and Pierce 1 ). On reviewing the literature at that time many papers were found which dealt with the recovery of morphine from tissues, the pharmacologic effects of morphine and the various types of treatment for morphinism, but little was found on the histopathologic picture during acute or chronic morphinism. The reports that were found on the latter phase of the subject concerned chiefly single cases in human beings, without comparison with