Recovery Of Memories Research Articles

Pre-adolescent and adolescent mice are less sensitive to the effects of acute nicotine on extinction and spontaneous recovery

Adolescence is a period of high risk for the initiation of nicotine product usage and exposure to traumatic events. In parallel, nicotine exposure has been found to age-dependently modulate acquisition of contextual fear memories; however, it is unknown if adolescent nicotine exposure alters extinction of fear related memories. Age-related differences in sensitivity to the effects of nicotine on fear extinction could increase or decrease susceptibility to anxiety disorders. In this study, we examined the effects of acute nicotine administration on extinction and spontaneous recovery of contextual fear memories in pre-adolescent (PND 23), late adolescent (PND 38), and adult (PND 53) C57B6/J mice. Mice were first trained in a background contextual fear conditioning paradigm and given an intraperitoneal injection of one of four doses of nicotine (0.045, 0.09, 0.18, or 0.36mg/kg, freebase) prior to subsequent extinction or spontaneous recovery sessions. Results indicated that all acute nicotine doses impaired extinction of contextual fear in adult mice. Late adolescent mice exhibited impaired extinction of contextual fear only following higher doses of acute nicotine, and extinction of contextual fear was unaffected by acute nicotine exposure in pre-adolescent mice. Finally, acute nicotine exposure enhanced spontaneous recovery of fear memory, but only in adult mice. Overall, our results suggest that younger mice were less sensitive to nicotine’s impairing effects on extinction of contextual fear and to nicotine’s enhancing effects on spontaneous recovery of contextual fear memory.

Photoinduced Recovery of Organic Transistor Memories with Photoactive Floating-Gate Interlayers.

Optical memories based on photoresponsive organic field-effect transistors (OFETs) are of great interest due to their unique applications, such as multibit storage memories and flexible imaging circuits. Most studies of OFET-type memories have focused on the photoresponsive active channels, but more useful functions can be additionally given to the devices by using floating gates that can absorb light. In this case, effects of photoirradiation on photoactive floating-gate layers need to be fully understood. Herein, we studied the photoinduced erasing effects of floating-gate interlayers on the electrical responses of OFET-type memories and considered the possible mechanisms. Polymer/C60 composites were inserted between pentacene and SiO2 to form photoresponsive floating-gate interlayers in transistor memory. When exposed to light, C60 generated excitons, and these photoexcited carriers contributed to the elimination of trapped charge carriers, which resulted in the recovery of OFET performance. Such memory devices exhibited bistable current states controlled with voltage-driven programming and light-driven erasure. Furthermore, these devices maintained their charge-storing properties over 10 000 s. This proof-of-concept study is expected to open up new avenues in information technology for the development of organic memories that exhibit photoinduced recovery over a wide range of wavelengths of light when combined with appropriate photoactive floating-gate materials.

Reconstruction in A Two-Person World May Be More About The Present Than The Past: Freud and The Wolf Man, an Illustration.

The psychoanalytic process of reconstruction has yet to be examined from the perspective of today's two-person psychologies. Earlier writers on the subject have implicated the analyst and his emotional involvement as influences that may distort the valid recovery of memories, while others have written that the transference and the reconstructed past are interdependent. By contrast with both views, it is suggested here that the reconstructed product itself may reflect the transference-countertransference engagement of the dyad: in some instances, and to some extent in all instances, the scene or story of the presumed past will be a version of the current analytic relationship. In certain cases consideration of the conscious and unconscious emotional entanglements of the dyad will reveal that the reconstruction says more about the analytic present than about the past. Freud's Wolf Man case provides a good illustration of this point. While a broad consensus exists that its famous primal scene reconstruction cannot be veridical, it has most often been dismissed as distorted by Freud's theoretical commitments. A closer examination of the relationship between Freud and Pankejeff reveals that the reconstruction is an accurate rendering of warded-off aspects of the dyad's way of being together. The potential clinical utility of adopting this perspective is that it encourages the analyst to reflect on his clinical reconstructions, interrogating them for clues to otherwise elusive aspects of the current clinical relationship.

Preventing the Return of Fear Using Reconsolidation Update Mechanisms Depends on the Met-Allele of the Brain Derived Neurotrophic Factor Val66Met Polymorphism.

Background:Memory reconsolidation is the direct effect of memory reactivation followed by stabilization of newly synthesized proteins. It has been well proven that neural encoding of both newly and reactivated memories requires synaptic plasticity. Brain derived neurotrophic factor (BDNF) has been extensively investigated regarding its role in the formation of synaptic plasticity and in the alteration of fear memories. However, its role in fear reconsolidation is still unclear; hence, the current study has been designed to investigate the role of the BDNF val66met polymorphism (rs6265) in fear memory reconsolidation in humans.Methods:An auditory fear-conditioning paradigm was conducted, which comprised of three stages (acquisition, reactivation, and spontaneous recovery). One day after fear acquisition, the experimental group underwent reactivation of fear memory followed by the extinction training (reminder group), whereas the control group (non-reminder group) underwent only extinction training. On day 3, both groups were subjected to spontaneous recovery of earlier learned fearful memories. The treat-elicited defensive response due to conditioned threat was measured by assessing the skin conductance response to the conditioned stimulus. All participants were genotyped for rs6265.Results:The results indicate a diminishing effect of reminder on the persistence of fear memory only in the Met-allele carriers, suggesting a moderating effect of the BDNF polymorphism in fear memory reconsolidation.Conclusions:Our findings suggest a new role for BDNF gene variation in fear memory reconsolidation in humans.

Contribuições do Método História de Vida para Estudos sobre Identidade: o exemplo do estudo sobre professoras gerentes

Recentemente, o método história de vida tem sido usado na área de Administração como uma importante estratégia metodológica nas pesquisas qualitativas. Com esse método busca-se compreender os grupos ou a coletividade a partir de trajetórias de vida individuais. Nesse sentido, o objetivo deste trabalho é discutir a contribuição do método da história de vida para a compreensão da dinâmica identitária de professoras gerentes de uma universidade pública, por meio de um exemplo proveniente de um estudo empírico. Verificou-se, a partir dos relatos de quatro professoras gerentes, que o resgate de memórias do passado e de valores, fatos, normas e acontecimentos ligados à socialização primária e organizacional das entrevistadas contribui para a compreensão da dinâmica identitária delas. Emergiram algumas categorias de análise que expressam relações entre a história de vida e a identidade como: a descontinuidade, subjetividade e a importância de “dar voz ao sujeito”; o individual e o social e as transformações sócio-históricas: uma interação dinâmica na construção de identidades; e a análise temporal na construção de identidades.

Recent advances in false memory research

In the last few years, substantial gains have been made in our understanding of human memory errors and the phenomenon of false memory, wherein individuals remember entire events that did not happen at all. Research had established that false memories can be consequential and emotional, that they can last for long periods of time, and that they are not merely the product of demand characteristics or the recovery of extant but hidden memories. These recent advances are discussed as extensions of earlier foundational research.

A model of cholinergic modulation in olfactory bulb and piriform cortex

In this work we investigate in a computational model how cholinergic inputs to the olfactory bulb (OB) and piriform cortex (PC) modulate odor representations. We use experimental data derived from different physiological studies of ACh modulation of the bulbar and cortical circuitry and the interaction between these two areas. The results presented here indicate that cholinergic modulation in the OB significantly increases contrast and synchronization in mitral cell output. Each of these effects is derived from distinct neuronal interactions, with different groups of interneurons playing different roles. Both bulbar modulation effects contribute to more stable learned representations in PC, with pyramidal networks trained with cholinergic-modulated inputs from the bulb exhibiting more robust learning than those trained with unmodulated bulbar inputs. This increased robustness is evidenced as better recovery of memories from corrupted patterns and lower-concentration inputs as well as increased memory capacity.

Low-Frequency Stimulation Depresses the Primate Anterior-Cingulate-Cortex and Prevents Spontaneous Recovery of Aversive Memories

Functional abnormalities in the dorsal-anterior-cingulate-cortex (dACC) underlie anxiety disorders and specifically post-traumatic stress disorder (PTSD). Promising and common behavioral approaches have limited effectiveness and many subjects exhibit spontaneous recovery of fear, as also evident in animal models following extinction training. Here, we use low-frequency stimulation (LFS), a protocol shown to induce long-term depression, with the aim of affecting synaptic plasticity induced by fear acquisition and extinction. We use aversive conditioning of either tone or visual stimuli paired with an aversive air-puff to the eye in a trace-conditioning paradigm. We find that LFS in the nonhuman primate (Macaca fascicularis) dACC, when combined with extinction training, was successful in preventing spontaneous recovery of the memory 24-72 h following extinction. We simultaneously record single-units and local-field-potentials across the dACC, and show that LFS gradually depressed evoked responses. Moreover, this decrease in neural excitability predicted the successful reduction of overnight spontaneous recovery on a day-by-day basis. Finally, we show that this effect occurs when using either visual or auditory modality as the conditioned stimulus, and that the reduction was specific to the conditioned modality. Our results suggest that the primate dACC is actively involved in maintaining the original aversive memory, and propose that a combination of LFS with behavioral therapy might significantly improve treatment in severe cases.

Ernst Kris

In 1956, the year before his death, Ernst Kris published a trilogy of papers on memory--"The Personal Myth," "On Some Vicissitudes of Insight in Psychoanalysis," and "The Recovery of Childhood Memories"--and was planning to publish a monograph on the subject. In his papers on memory, by juxtaposing his clinical work with adult patients and his research on very young children, Kris sketched a trajectory of the dynamic relationship between preoedipal ego development and object relations, against the backdrop of psychosexual stages and the defenses that mediate memory. Kris was firmly committed to the premise that "the development of ego functions and object relations . . . are of equal and intrinsic importance." This paper explores how Kris's papers on memory may also be read as delineating his thinking on the role of object relations in infants and young children. In his last paper, the posthumously published "Decline and Recovery in the Life of a Three-Year-Old" (1962), his interest in ego development and object relations shifts to object relations, but the role of memory remains crucial. The paper concludes with some observations about the omissions and distortions that characterize how the history of psychoanalysis is recalled, orally transmitted, and written.

Nonverbal Behaviors in the Analytic Situation: The Search for Meaning in Nonverbal Cues

Two extended clinical examples are offered to show the value of attending to nonverbal behaviors in the analytic situation. Such kinesics may be highly charged transference actualizations that lead to the recovery of early memories. The material is viewed primarily from the theoretical standpoint of separation-individuation dynamics. The author argues that nonverbal phenomena should not be viewed as inferior to verbal communications or as less central to analytic work. (PLR)

Autobiographic memory: Phenomenological aspects, personal semantic knowledge, generic events and characters (one case of pure retrograde memory recovery)

Tulving et al. [Brain Cogn 8 (1988) 3-20] proposed an operational distinction concerning memory between a semantic component consisting of general information about the individual's past and an episodic component, containing memories of specific events that can be situated in space and time. After a mild head trauma and in the context of professional troubles, patient FF displayed a pure retrograde amnesia concerning both his biographical identity and semantic memories. The patient could no longer access his memories. However, these did not seem completely lost since his answers to tests concerning historical events were better than random, his answers to a television quiz were automatic, he showed temporal transfer phenomena (ecmnesia) and since he retrieved the entirety of his memories within nine months. The patient FF illustrates the loss of retrograde autobiographic memory and the recovery of episodic memories, which requires three elements: a sense of subjective time, an autonoetic awareness (the ability to be aware of subjective time) and a "self" that can travel in subjective time.

Regaining the Lost Past

People with Alzheimer’s disease or related neurodegenerative disorders may progress from absentmindedness and difficulty learning new things to a heartbreaking state in which they forget their own past and no longer recognize the faces of people they love. Expression of p25 (a truncated form of the p35 regulatory subunit of cyclin-dependent kinase 5) is associated with various neurodegenerative disorders, and the CK-p25 Tg mouse, in which p25 expression--and thereby neuronal loss--can be conditionally regulated, is a model for these disorders. Fischer et al . found that exposing CK-p25 Tg mice to an enriched environment (after neuronal loss had occurred and learning was impaired) improved their associative and spatial learning. Moreover, environmental enrichment led to the recovery of long-term memories that had apparently been lost. Experiments in wild-type mice revealed that exposure to an enriched environment stimulated histone acetylation in the hippocampus and cortex. The histone deacetylase (HDAC) inhibitor sodium butyrate (SB) improved associative and spatial learning in wild-type and CK-p25 Tg mice (after p25 induction) and, like environmental enrichment, enhanced dendritic and synaptic growth in CK-p25 Tg mice without affecting brain atrophy or neuronal loss. Furthermore, SB enabled the recovery of lost memories. The authors conclude that their data raise the possibility that HDAC inhibitors may provide a means to enable people with neurodegenerative disorders associated with memory loss to recover lost memories. Sweatt provides thoughtful commentary, noting (as do the authors) that HDAC inhibitors may affect the acetylation status of proteins other than histones. A. Fischer, F. Sananbenesi, X. Wang, M. Dobbin, L. H. Tsai, Recovery of learning and memory is associated with chromatin remodelling. Nature 447 , 178-182 (2007). [PubMed] J. D. Sweatt, Down memory lane. Nature 447 , 151-152 (2007). [PubMed]

Recovery of learning and memory is associated with chromatin remodelling

Neurodegenerative diseases of the central nervous system are often associated with impaired learning and memory, eventually leading to dementia. An important aspect in pre-clinical research is the exploration of strategies to re-establish learning ability and access to long-term memories. By using a mouse model that allows temporally and spatially restricted induction of neuronal loss, we show here that environmental enrichment reinstated learning behaviour and re-established access to long-term memories after significant brain atrophy and neuronal loss had already occurred. Environmental enrichment correlated with chromatin modifications (increased histone-tail acetylation). Moreover, increased histone acetylation by inhibitors of histone deacetylases induced sprouting of dendrites, an increased number of synapses, and reinstated learning behaviour and access to long-term memories. These data suggest that inhibition of histone deacetylases might be a suitable therapeutic avenue for neurodegenerative diseases associated with learning and memory impairment, and raises the possibility of recovery of long-term memories in patients with dementia.

Effects of prior knowledge and expert statement on belief in recovered memories: An international perspective

We tested the hypothesis that beliefs in the purported attributes of recovered memories of child sexual abuse (CSA) are associated with knowledge of the “recovered/false memory debate”, and that such beliefs will be related to assessments of the credibility of statements made by participants in a vignette about CSA. Participants from five countries (the United States, Canada, New Zealand, the United Kingdom and Israel) responded to a questionnaire regarding beliefs about recovered memory as well as self-reported exposure to and knowledge of the debate. In addition, they assessed the credibility of statements made by a daughter (reporting recovery of memories of sexual abuse by her father), her father (denying the allegation and accusing the daughter's therapist of implanting in her false “memories” of abuse), and two experts (each supporting one of the two protagonists). We found that prior knowledge of the debate across countries was linked to beliefs in specific attributes of recovered memories and to a subset of the credibility assessments of statements made by the protagonists and their experts. For individuals, however, credibility assessments were unrelated to knowledge of the debate, but they were related to beliefs about memory recovery. Finally, credibility of the protagonists' statements was differentially associated with those made by the daughter's and the father's experts. The results suggest that whereas familiarity with the debate does not affect the credibility of the statements made by the complainant and the accused, expert testimony does, as has been found in prior research. The psycholegal implications of this conclusion are discussed.

Sleep's function in the spontaneous recovery and consolidation of memories.

Building on 2 previous studies (B. R. Ekstrand, 1967; B. R. Ekstrand, M. J. Sullivan, D. F. Parker, & J. N. West, 1971), the authors present 2 experiments that were aimed at characterizing the role of retroactive interference in sleep-associated declarative memory consolidation. Using an A-B, A-C paradigm with lists of word pairs in Experiment 1, the authors showed that sleep provides recovery from retroactive interference induced at encoding, whereas no such recovery was seen in several wake control conditions. Noninterfering word-pair lists were used in Experiment 2 (A-B, C-D). Sleeping after learning, in comparison with waking after learning, enhanced retention of both lists to a similar extent when encoding was less intense because of less list repetition and briefer word-pair presentations. With intense encoding, sleep-associated improvements were not seen for either list. In combination, the results indicate that the benefit of sleep for declarative memory consolidation is greater for weaker associations, regardless of whether weak associations result from retroactive interference or poor encoding.

Belief and experience of memory recovery

AbstractA number of large‐scale surveys have shown that many adults, particularly university students, believe that traumatic memories can be repressed and then recovered at a later point in time. How do ordinary people like students, most of whom may not have experiences of repression or recovery of traumatic events, come to believe in such phenomenon? Such belief may be associated with daily experiences of forgetting and remembering. We asked 111 undergraduates to rate how likely they would think a person (in daily life) would remember what she/he had completely forgotten, and to write down such experiences, if they had any. Also we asked them to rate 39 statements on memory including repression and recovery of memory, and traumatic memory. Overall, 71% of participants thought that it was likely that one would remember what she/he had completely forgotten; 70% of participants reported that they actually had such experiences. Although most of the episodes that students reported reflected normal forgetting and remembering in daily life, the number of episodes as well as the belief and experience of such forgetting and remembering were correlated with their belief measures on repression and recovery of traumatic memories. Belief and experience of daily memory phenomenon may have something to do with creation and/or maintenance of belief in repressed/recovered memory. Copyright © 2006 John Wiley & Sons, Ltd.

Recovered Memories

The issues surrounding repressed, recovered, or false memories have sparked one of the greatest controversies in the mental health profession in the twentieth century. We review evidence concerning the existence of the repression and recovery of autobiographical memories of traumatic events and research on the development of false autobiographical memories, how specific therapeutic procedures can lead to false memories, and individual vulnerability to resisting false memories. These findings have implications for therapeutic practice, for forensic practice, for research and training in psychology, and for public policy.

Recovery of fear memories in rats: Role of gamma-amino butyric acid (GABA) in infantile amnesia.

Infantile amnesia is a ubiquitous phenomenon, but its neural bases remain largely unknown. The authors identify a role for GABAergic transmission in suppressing retrieval of memories acquired in infancy. Eighteen-day-old rats received pairings of white noise and shock; considerable forgetting of this experience (assessed by freezing) occurred after 10 days. The memory was recovered by pretest administration of the GABAA inverse agonist FG7142 10 days, but not 2 months, after training. This effect of FG7142 generalized when a passive avoidance procedure was used. Also, FG7142 decreased fear of a latently inhibited conditioned stimulus, showing that the observed memory recovery effect was not due to a state-dependent process. It appears that GABA may be involved in infantile amnesia regardless of the emotional content of the memory.

Affect and the therapeutic action of psychoanalysis

In connection with controversial IJP articles by Stern et al. and Fonagy on the interpretation of the repressed and the recovery of past memories, the author maintains that the affect that is inherent in positive transference is at the heart of therapeutic action. Points of view put forward in the controversy (based on neurobiological knowledge) are related to Freudian metapsychology, as well as to their precursors whose scope was necessarily limited by a lack of access to more recent scientific discoveries. The author demonstrates metapsychological elements of therapeutic action inherent in the intersubjective relationship, especially identification, manifested in introjection and empathy. He describes cognitive development as spontaneously blossoming from the affective nucleus, and he explains the neuroscientic bases of this step forward. The classic (interpretative) psychoanalytic method makes up the cognitive superstructure necessary for the organisation of the mind that has sprung from the affective substructure. As a primary factor in psychic change, interpretation is limited in effectiveness to pathologies arising from the verbal phase, related to explicit memories, with no effect in the pre‐verbal phase where implicit memories are to be found. Interpretation the method used to the exclusion of all others for a century is only partial; when used in isolation it does not meet the demands of modern broad‐spectrum psychoanalysis, as the clinical material presented illustrates.

Remembering the past, anticipating a future

To provide an overview of the phenomena of recovered memories and false memories of past traumas and to provide illustrations with clinical vignettes as well as historical observations. The questions concerning the recovery of memories of trauma do not readily reduce to simple dichotomies. Whatever the terminology applied, be it repression, dissociation or forgetting, humans have a capacity to not consciously know about aspects of their traumas for extended periods of time. The nature of memory is reconstructive. Memory is not a digital recording that provides for a totally accurate replay. Multiple factors including the age at which traumas occurred, the relationships to the person responsible or the nature and extent of the traumas influence what will be accessible to memory. In regard to those patients who describe recovered memories, it is important that clinicians take an individualistic approach and remain open-minded. They should not feel pressure to validate or reject the claim; rather, they should respect and empower patients.