ABSTRACT Improving the Internal Combustion Engines (ICEs) overall thermal efficiency is crucial to reduce fuel consumption and emissions. To achieve this goal, waste heat recovery from exhaust gases remains the most promising strategy, which involves the utilization of compact heat exchangers. This study evaluates the performance of novel Monolithic Integrated Thermal Exchange Matrixes (MITEMs) designs for recovering exhaust heat from a 70 hp diesel engine, focusing on the impact of inlet/outlet cavities. Computational Fluid Dynamics simulations were employed to analyze the heat transfer rate, pressure drop, and overall thermal-hydraulic performance of different MITEM designs. The Rectangular Channels with Large Cavities (RCLC) design exhibited superior performance, enhancing the heat transfer rate by 14.7% compared to the baseline design while limiting pressure drop increase to 9.2%. The RCLC design increased local Nusselt numbers and heat transfer coefficients by up to 60%, achieving peak velocities of 98 m/s within cross-sectional planes. These findings provide valuable insights for optimizing exhaust heat recovery systems in diesel engines.