Record Information Research Articles

Suplatast tosilate reduces peripheral blood eosinophil levels in patients with eosinophilia: A real-world retrospective study

IntroductionEosinophilia is a rare disease characterized by an increase in eosinophils. Suplatast tosilate is a selective Th2 cytokine inhibitor that can reduce eosinophils. There is currently a lack of clinical studies of suplatast tosilate in the treatment of eosinophilia. Research objectiveTo explore whether suplatast tosilate can reduce blood eosinophil levels in eosinophilia and the factors that might influence the improvement. MethodsA real-world retrospective study of 20 patients with eosinophilia was conducted using electronic medical record information. The main outcome measure was the difference in peripheral blood absolute eosinophil count (AEC) and percentage (EOS%) before suplatast tosilate (baseline) and the lowest AEC during the 1-year period of suplatast tosilate treatment (post-treatment). Data on age, gender, disease duration, involved organs, and concomitant medication were collected, and subgroup analysis and linear regression analysis were performed. ResultsSubjects were predominantly male, with a mean age of 33 years and a disease duration of approximately 30 months. After treatment with suplatast tosilate, the patient's AEC (p ​= ​0.029) and EOS% (p ​= ​0.016) significantly decreased. The decline in eosinophils was more pronounced in patients who were male, age <33 years, disease duration <30 months and gastrointestinal system involvement. In addition, the shorter the course of the disease, the greater the relative decrease in eosinophils after suplatast tosilate treatment (β ​= ​−0.018, p ​< ​0.001). ConclusionsSuplatast tosilate is effective in reducing peripheral blood eosinophil levels in patients with eosinophilia. Large-scale prospective cohort studies are needed for further confirmation.

Technical challenges and benefits of photon counting detector computed tomography

X-ray detector is the essential part of a computed tomography (CT) system that controls dose efficiency and image quality. All clinical CT scanners utilized scintillating detectors up until the first clinical photon-counting-detector (PCD) system was approved in 2021. These detectors do not record information about individual photons during the two-step detection process. PCDs, on the other hand, employ a single step process that transforms X-ray radiation straight into an electrical signal. This retains information on individual photons, allowing one to count the quantity of X-rays in various energy ranges. Better spatial resolution, reduced dosages of iodinated contrast material, enhanced iodine signal, enhanced radiation dose efficiency, and the lack of electronic noise are the main benefits of PCDs. PCDs with multiple energy thresholds are able to separate detected photons into two or more energy bins, allowing for the availability of energy-resolved data for each record. In the event of dual-source CT, this permits high pitch or high temporal resolution acquisitions in addition to high spatial resolution for tasks involving material quantification or classification. PCDCT imaging of anatomy, where excellent spatial resolution provides clinical benefit, is one of the most promising uses of the technology. Inner ear, bone, small blood artery, heart, and lung imaging are among them. Photon-counting CT will become the wave of the future for workhorse CT imaging systems. An overview of the PCDCT principle, possible clinical benefits, and limitations of conventional CT is provided in this review paper, along with potential future developments for this CT imaging technology.

Magnetization Switching of Single Magnetite Nanoparticles Monitored Optically.

Magnetic nanomaterials record information as fast as picoseconds in computer memories but retain it for millions of years in ancient rocks. This exceedingly broad range of times is covered by hopping over a potential energy barrier through temperature, ultrafast optical excitation, mechanical stress, or microwaves. As switching depends on nanoparticle size, shape, orientation, and material properties, only single-nanoparticle studies can eliminate the ensemble heterogeneity. Here, we push the sensitivity of photothermal magnetic circular dichroism down to individual 20 nm magnetite nanoparticles. Single-particle magnetization curves display superparamagnetic to ferromagnetic behaviors, depending on the size, shape, and orientation. Some nanoparticles undergo thermally activated switching on time scales of milliseconds to minutes. Surprisingly, the switching barrier varies with time, leading to dynamical heterogeneity, a phenomenon familiar in protein dynamics and supercooled liquids. Our observations will help to identify the external parameters influencing magnetization switching and, eventually, to control it, an important step for many applications.

A DNA-Like blockchain model: implementing decentralized management, dynamic scheme adjustment, and data security for optimal service composition

ABSTRACT Cloud manufacturing (CM) promotes the development of small and medium-sized manufacturing enterprises (SMMEs) by integrating resources and collaboratively providing users with diversified services. However, the implementation of CM for SMMEs faces several challenges, such as the excessive centralization of enterprise management, poor dynamic adaptability of service composition, and insecurity of data information. To address these issues, this paper proposes a DNA-like blockchain model (DNABM) based on blockchain technology. The DNABM consists of a service information chain (SIC) and a manufacturing process chain (MPC). The SIC nodes (SIblocks) are formed based on the corresponding subtasks to record information about all manufacturing services that can complete the subtasks. The MPC nodes (MPblocks) are formed by selecting the most suitable services from the SIblocks. The DNABM has advantages of flexible service management, dynamically adaptable service compositions, and securely managed manufacturing enterprise data across various levels. Finally, taking the foundry industry as an example, demonstrating how the DNABM can promote the collaboration of SMMEs in CM. However, the actual implementation of the DNABM is still limited by the large number of heterogeneous tasks and services, the low utilization rate of process data, and the lack of coordination compatibility between services.

Analisis Kesiapan Implementasi Rekam Medis Elektronik Rawat Jalan di Rumah Sakit X

Changing the medical record information system from manual to electronic will make it easier to record information about patients in a practical and fast way. This change is related to the Regulation of the Minister of Health of the Republic of Indonesia, namely that all health facilities are expected to have implemented electronic medical records in accordance with the provisions no later than December 31, 2023. In this case, it is necessary to know the level of readiness of hospitals in implementing outpatient electronic medical records. The purpose of this study was to analyze to determine the readiness of implementing outpatient electronic medical records at Hospital X using the Doctor's Office Quality – Information Technology (DOQ-IT) method. The type of research used is descriptive quantitative. The research instrument is a questionnaire. Readiness analysis using the EHR Readiness Starter Assessment from DOQ-IT. The level of readiness for the implementation of outpatient electronic medical records at Tk. III Dr. R. Soeharsono Banjarmasin is very well prepared. This value is included in the very ready score range. While the level of readiness for implementation in the variable, namely, organizational work culture of 42.14 is in the very ready score range, 34.72 leadership governance is in the very ready score range, human resources is 21.19 in the very ready score range, and IT infrastructure of 15.69 is in the fairly ready range of scores.

Symbolic recording of signalling and cis-regulatory element activity to DNA.

Measurements of gene expression or signal transduction activity are conventionally performed using methods that require either the destruction or live imaging of a biological sample within the timeframe of interest. Here we demonstrate an alternative paradigm in which such biological activities are stably recorded to the genome. Enhancer-driven genomic recording of transcriptional activity in multiplex (ENGRAM) is based on the signal-dependent production of prime editing guide RNAs that mediate the insertion of signal-specific barcodes (symbols) into a genomically encoded recording unit. We show how this strategy can be used for multiplex recording of the cell-type-specific activities of dozens to hundreds of cis-regulatory elements with high fidelity, sensitivity and reproducibility. Leveraging signal transduction pathway-responsive cis-regulatory elements, we also demonstrate time- and concentration-dependent genomic recording of WNT, NF-κB and Tet-On activities. By coupling ENGRAM to sequential genome editing via DNA Typewriter1, we stably record information about the temporal dynamics of two orthogonal signalling pathways to genomic DNA. Finally we apply ENGRAM to integratively record the transient activity of nearly 100 transcription factor consensus motifs across daily windows spanning the differentiation of mouse embryonic stem cells into gastruloids, an in vitro model of early mammalian development. Although these are proof-of-concept experiments and much work remains to fully realize the possibilities, the symbolic recording of biological signals or states within cells, to the genome and over time, has broad potential to complement contemporary paradigms for how we make measurements in biological systems.

Recovery of damaged information via scrambling in indefinite causal order

Scrambling prevents the access to local information with local operators and therefore can be used to protect quantum information from damage caused by local perturbations. Even though partial quantum information can be recovered if the type of the damage is known, the initial target state cannot be completely recovered, because the obtained state is a mixture of the initial state and a maximally mixed state. Here, we demonstrate an improved scheme to recover damaged quantum information via scrambling in indefinite causal order. We show that scheme with indefinite causal order can record information of the damage and distill the initial state from the damaged state simultaneously. It allows us to retrieve initial information versus any damage. Moreover, by iterating the schemes, the initial quantum state can be completely recovered. In addition, we experimentally demonstrate our schemes on the cloud-based quantum computer, named as Quafu. Our work proposes a feasible scheme to protect whole quantum information from damage, which is also compatible with other techniques such as quantum error corrections and entanglement purification protocols. We expect that our scheme will be useful in the both quantum information recovery from the damage and systems bench-marking.

Influence of technical skill level and sport specialization on surfing injuries: A cross-sectional study

ObjectiveThis study aimed to analyze the influence of sport specialization and the level of technical skills on injury risk in male surfers. DesignDescriptive epidemiological study. SettingWeb-based surveys. Participants295 male surfers participated in the present study, of whom 25 (8.47%) were competitive surfers, and 270 (91.53%) were recreational surfers. Main outcome measureThis study consisted of a single registry. A web-based survey was used to record information on the injuries sustained during the past year. ResultsNo association was detected between the surfer's performance level and having suffered an injury during the practice (p > 0.05). Conversely, the results indicated that the higher the level of specialization, the greater the likelihood of suffering a sports-related injury (χ2 (3) = 12.9 p = 0.005; ES = 0.20). In addition, surfers who showed a medium-high self-concept of their skills (scores of 6, 7, and 8) tend not to get fewer injuries (χ2 (8) = 36.8 p < 0.001; ES = 0.35. Conclusionhigher-level specialization surfers tend to suffer more injuries than lower-specialization surfers. Nevertheless, a good self-concept of technical skills may contribute to a lower likelihood of injury.

Documentation as part of substance use rehabilitation: how workers account for the significance of documentation during interviews

PurposeThe focus of this article is in documentation in substance abuse inpatient rehabilitation. Our article scrutinizes how workers give accounts of the documentation in the inpatient substance abuse rehabilitation unit and what kind of client information the workers record.Design/methodology/approachThe study focuses on institutional interaction and practices. Our data consist of interviews with substance abuse rehabilitation professionals (N = 15). We analyzed the interviews using content analysis and the account concept in keeping with the ethnomethodological research tradition.FindingsStudy shows how workers account for the significance of documentation. Workers deemed documentation significant in four different ways: in gathering basic and rehabilitation information, in storing and transmitting information, as a tool for analysis and assessment and in supporting linguistic transparency in substance abuse rehabilitation. Workers justified the significance of documentation by the legal requirement to record information about clients. Documented information enables clear management of client information and supports substance abuse rehabilitation work in various ways. Documentation contains descriptions of the client’s situation and work performed. Additionally, documentation serves as a tool for communication among social care professional.Originality/valueThus the research show that documentation plays a significance part in the inpatient substance abuse rehabilitation and are connected to its institutional tasks and practices.

Case recording in child protection: An exploration of the evidence base and good practice

AbstractThere is a statutory duty for all practitioners to record information in child protection work in England. Case recording is a daily task for practitioners, yet an under‐researched area of practice. This continuing professional development (CPD) paper will consider the context in which case recording takes place and highlight messages from child protection reviews and enquiries before exploring learning from contemporary research. The complexities of case recording will be considered and how practitioners can reflect upon and improve their daily case recording skills. Practitioners are encouraged to keep the child's views and experiences central and consider the long‐term impact of case recording on adults who have experienced abuse and neglect in childhood.

Social determinants of health and disparities in spine surgery: a 10-year analysis of 8,565 cases using ensemble machine learning and multilayer perceptron

BACKGROUND CONTEXTThe influence of SDOH on spine surgery is poorly understood. Historically, researchers commonly focused on the isolated influences of race, insurance status, or income on healthcare outcomes. However, analysis of SDOH is becoming increasingly more nuanced as viewing social factors in aggregate rather than individually may offer more precise estimates of the impact of SDOH on healthcare delivery. PURPOSEThe aim of this study was to evaluate the effects of patient social history on length of stay (LOS) and readmission within 90 days following spine surgery using ensemble machine learning and multilayer perceptron. STUDY DESIGNRetrospective chart review. PATIENT SAMPLE8,565 elective and emergency spine surgery cases performed from 2013 to 2023 using our institution's database of longitudinally collected electronic medical record information. OUTCOMES MEASURESPatient LOS, discharge disposition, and rate of 90-day readmission. METHODSEnsemble machine learning and multilayer perceptron were employed to predict LOS and readmission within 90 days following spine surgery. All other subsequent statistical analysis was performed using SPSS version 28. To further assess correlations among variables, Pearson's correlation tests and multivariate linear regression models were constructed. Independent sample t-tests, paired sample t-tests, one-way analysis of variance (ANOVA) with post-hoc Bonferroni and Tukey corrections, and Pearson's chi-squared test were applied where appropriate for analysis of continuous and categorical variables. RESULTSBlack patients demonstrated a greater LOS compared to white patients, but race and ethnicity were not significantly associated with 90-day readmission rates. Insured patients had a shorter LOS and lower readmission rates compared to non-insured patients, as did privately insured patients compared to publicly insured patients. Patients discharged home had lower LOS and lower readmission rates, compared to patients discharged to other facilities. Marriage decreased both LOS and readmission rates, underweight patients showcased increased LOS and readmission rates, and religion was shown to impact LOS and readmission rates. When utilizing patient social history, lab values, and medical history, machine learning determined the top 5 most-important variables for prediction of LOS —along with their respective feature importances—to be insurance status (0.166), religion (0.100), ICU status (0.093), antibiotic use (0.061), and case status: elective or urgent (0.055). The top 5 most-important variables for prediction of 90-day readmission—along with their respective feature importances—were insurance status (0.177), religion (0.123), discharge location (0.096), emergency case status (0.064), and history of diabetes (0.041). CONCLUSIONSThis study highlights that SDOH is influential in determining patient length of stay, discharge disposition, and likelihood of readmission following spine surgery. Machine learning was utilized to accurately predict LOS and 90-day readmission with patient medical history, lab values, and social history, as well as social history alone.

Prevalence of Periodontal Disease Among Undergraduate Students In AL-Qadisiyah Governorate, Iraq: A Cross-Sectional Study

Periodontal disease, which involves gingivitis and periodontitis, is a common oral infection that affects the tissues that surround and support the teeth. Previously there were no epidemiological studies to assess the prevalence of periodontal disease in Al-Qadisiyah governorate generally and Al-Qadisiyah colleges and institute specifically. Therefore, an epidemiological study to determine the prevalence of periodontal diseases is essentially needed. To assess the prevalence of periodontal disease for the final year undergraduate students at all colleges and institute in Al-Qadisiyah governorate, Iraq and investigate the effect of age, gender, socioeconomic status, marital status and lifestyle factors on periodontal health status. A cross-sectional study was performed in AL-Qadisiyah colleges and institute. A total of 800 last stages students were examined using the community periodontal index for treatment needs and chosen randomly through stratified random sampling. A questionnaire was used to record information about socioeconomic status, marital status, and lifestyle, and correlated with periodontal health status. The overall prevalence rate of periodontal disease for the final year of undergraduate students in Al-Qadisiyah colleges and institute was 84.6%. Bleeding code 1 and calculus code 2 recorded approximately similar percentages (31.5%) and (31.4) respectively and only 15.4 % of students had healthy periodontium, while the percentage of shallow and deep pockets recorded 18.4 % and 3.4% respectively. Community periodontal index for treatment needs varied non-significantly among marital status in which single students had healthier periodontium (16.5%) compared to married. The statistical analysis also showed that students with very good socioeconomic status and good lifestyle had the highest percentages of healthy periodontium (50%), (22.6%) respectively. The present study shows a higher prevalence rate of bleeding and calculus among final year of undergraduate students in Al–Qadisiyah colleges and institute with a lack of knowledge about periodontal health status. Hence, there are significant associations of age, gender, marital status, socioeconomic status, and lifestyle with periodontal health conditions, also the results indicated that the majority of the students need preventive programs to reduce PDs initiation or progression.

Pemeliharaan Dan Pengamanan Arsip Keluarga Melalui Tindakan Alih Media

This Community Service activity is carried out in partnership with the target group, which consists of the mothers of students from the Play Group and Kindergarten of Cahya Hati, located in Mulyoagung Village, Dau District, Malang Regency, East Java. The purpose of this activity is to provide understanding and training to mothers in managing family archives through media conversion. The reason for choosing the target partner is that the mother is the one who manages the daily life of the family. One of them is in managing family documents. Family documents need to be archived to record information and be easily retrieved when needed. The transfer of archival media is carried out with the aim of ensuring the safety of family archives, such as from the dangers of flooding, fire, and other hazards. The community service activities were conducted using methods of lectures, discussions, and simple media transfer training, followed by the storage of family archives resulting from the media transfer actions. The result of this community service activity is that the mothers involved gained experience in transferring family archive media, and then immediately practiced it on their own family documents.

Akurasi dan Ketepatan Pengkodean Diagnosis pada Kasus Obstetric di RST Dr. Asmir DKT Salatiga

Accurate and precise diagnosis coding in obstetric cases at Dr. Asmir DKT Hospital, Salatiga, is crucial for effective medical record management. This study utilized an analytical quantitative approach with a cross-sectional method to explore the relationship between the accuracy and precision of diagnosis coding. The sample comprised 100 obstetric cases selected from inpatients during the first quarter (January – March 2024). Data analysis revealed that 68% of the 72 analyzed cases had accurate diagnosis coding, while 32% were inaccurate. Similarly, 71% of the cases were coded precisely, with 29% coded imprecisely. Chi-Square analysis indicated a significant relationship between accuracy and precision of diagnosis coding (p = 0.002). Factors influencing inaccuracies and imprecisions in coding included legibility of physician notes in medical records, inadequate understanding of the coding system (ICD-10), and completeness of medical documentation. To enhance coding quality, regular training for healthcare staff is recommended, alongside strengthening internal audit systems and developing more efficient medical record information systems.

Practical guidelines for Bayesian phylogenetic inference using Markov Chain Monte Carlo (MCMC)

Phylogenetic estimation is, and has always been, a complex endeavor. Estimating a phylogenetic tree involves evaluating many possible solutions and possible evolutionary histories that could explain a set of observed data, typically by using a model of evolution. Modern statistical methods involve not just the estimation of a tree, but also solutions to more complex models involving fossil record information and other data sources. Markov Chain Monte Carlo (MCMC) is a leading method for approximating the posterior distribution of parameters in a mathematical model. It is deployed in all Bayesian phylogenetic tree estimation software. While many researchers use MCMC in phylogenetic analyses, interpreting results and diagnosing problems with MCMC remain vexing issues to many biologists. In this manuscript, we will offer an overview of how MCMC is used in Bayesian phylogenetic inference, with a particular emphasis on complex hierarchical models, such as the fossilized birth-death (FBD) model. We will discuss strategies to diagnose common MCMC problems and troubleshoot difficult analyses, in particular convergence issues. We will show how the study design, the choice of models and priors, but also technical features of the inference tools themselves can all be adjusted to obtain the best results. Finally, we will also discuss the unique challenges created by the incorporation of fossil information in phylogenetic inference, and present tips to address them.

Antithrombotic Questionnaire Tool for Evaluation of Combined Antithrombotic Therapy in Community Pharmacies.

The objective of this paper is to assess the diagnostic value of an antithrombotic questionnaire tool compared with the hospital's medical record information tool. The hypothesis of this study was that the antithrombotic questionnaire tool could identify patients with potentially incorrect antithrombotic therapy. This cross-sectional study was conducted in eight community pharmacies in the Netherlands. A standardized questionnaire was developed as antithrombotic questionnaire tool. The pharmacist assessed whether the antithrombotic therapy was correct or potentially incorrect based on answers given by patients and based on the medical record. The primary outcome of the study was the sensitivity and specificity of the antithrombotic questionnaire tool to identify patients with potentially incorrect antithrombotic therapy. For 95 patients, the pharmacist assessed that in 81 (85%) the antithrombotic therapy was correct and in 14 (15%) potentially incorrect. Based on the medical record, 86 patients (91%) were assessed as correct and 9 (9%) as potentially incorrect. The sensitivity of the tool was 100% and the specificity 94%. This study demonstrated that the antithrombotic questionnaire tool is a suitable tool to assess whether the patient's antithrombotic therapy is potentially incorrect. It can be applied to identify patients with potentially incorrect antithrombotic therapy.

Evaluation of a Suspected Overdose Form for Timely Surveillance of Fatal Drug Overdoses, Multnomah County, OR, 2020-2021.

There is a significant delay in finalization of drug overdose deaths, and a need to more quickly identify suspected overdoses to improve public health response. The objective of our study was to describe creation of a suspect overdose form and evaluate its use. Evaluation of a suspected overdose form used to record information related to death investigation with matching to state vital records. We calculated the toxicology turnaround time for matched records, and also calculated sensitivity, specificity, positive predictive value, and negative predictive value of the form compared to vital records as the gold standard. Multnomah County, Oregon, deaths investigated by the County Medical Examiner between January 2020 and December 2021. Sensitivity of the suspected overdose form. We analyzed 2818 matched death records in total during the study period. The average turnaround time for the 1673 records with toxicology results was 101days. In 2020, sensitivity of the form was 74%, but this increased to nearly 95% in 2021. Multnomah County's suspected evaluation form provides a timelier indicator of deaths suspected to be from drug overdose, has good sensitivity to detect true overdoses, and can help guide more rapid public health and public safety response activities.

Solusi Model Pendidikan Islam Bagi Anak Berkebutuhan Khusus di Sekolah Inklusif

This research explains the study of Islamic education for children with special needs who study in inclusive schools. Inclusive schools are schools that provide inclusive education where the education system provides opportunities for students with special needs to receive educational services together with students in general. The method or approach used in this study is library research. With this method, researchers collect, read, analyze, record and process information related to the research variables of this paper. The results of this research show, Islamic education is the right of every Muslim without any reason. Islamic education has an obligation to lead students to happiness in this world and the hereafter. Children with special needs also have the same rights as God's servants on earth, they have potential that must be developed so that they can benefit themselves and the wider community. Islamic education in inclusive schools can be realized well if there is strong synergy from every supporting element, from the government, school management, teachers, parents and the surrounding community, as well as the students.

Living Conditions of Migrant Students in Brazil

The migration scenario faces different conditions, with emphasis on the context of education and its repercussions on the individual's life. Therefore, the general objective was to investigate the living conditions of migrant students in Brazil. An Integrative Literature Review was carried out, involving: elaboration of the guiding question; literature search and sampling; data collect; critical analysis of studies; discussion of results; and presentation of the integrative review. The results made it possible to select 8 studies using the inclusion and exclusion criteria. Subsequently, a framework was developed to record information based on the “Preferred Reporting Items for Systematic Reviews and Meta-Analyses” protocol. Five points were grouped: Education, Housing, Labor Market, Income and Health. Prior to this, the profile of the migrant population wascreated. Finally, the need to build policies and enforce rights to guarantee better living conditions for the migrant population was highlighted, in the fight against social inequality in the Brazilian context.

Genetic relationship between petroleum evolution and mercury mineralization: Insights from calcite U[sbnd]Pb dating, geochemical characterization, and solid bitumen TEM analysis

A spatial association between hydrocarbon reservoirs and metalliferous deposits is found worldwide. However, the genetic relationship between them is unclear. The associated fluids record information related to petroleum evolution and mineralization. Integrating UPb dating and geochemical analysis on calcite associated with either bitumen or cinnabar and transmission electron microscopy analysis of the bitumen along the mercury belt of the Xuefeng Uplift, South China, this work provides evidence supporting that hydrocarbons are critical in mercury mineralization. The UPb age for the calcite associated with either bitumen (395–402 Ma) or cinnabar (389–391 Ma) indicates that oil migration/accumulation and mercury mineralization were broadly coeval. The similar geochemical data (δ13C–δ18O and REE) on bitumen- and cinnabar-associated calcite indicate that they are cogenetic and derived from the dissolution of the limestone under low temperatures. High mercury abundance (0.20% to 0.36%) and the nanoscale mercury-bearing isolated aggregates within the solid bitumen indicate that the hydrocarbons could have functioned as a mercury carrier before mineralization. Furthermore, the similar evolution trend of the sulfur isotope composition among cinnabar, the contemporaneous seawater sulfate and gypsum, and the higher S/C atomic ratio (>0.03) of the bitumen indicate that petroleum participated in thermochemical sulfate reduction and could be a vital mechanism for mercury precipitation. After generating from the organic-rich shale, the hydrocarbons and ore-forming fluids migrated, and the hydrocarbons might have functioned as a carrier and reducing agent during mercury mineralization.