Record Of History Research Articles

Safety profile of rivaroxaban in first-time users treated for venous thromboembolism in four European countries.

The European rivaroxaban post-authorization safety study evaluated bleeding risk among patients initiated on rivaroxaban or vitamin K antagonists for the treatment and secondary prevention of venous thromboembolism in routine clinical practice. Cohorts were created using electronic healthcare databases from the UK, the Netherlands, Germany and Sweden. Patients with a first prescription of rivaroxaban or vitamin K antagonist during the period from December 2011 (in the UK, January 2012) to December 2017 (in Germany, December 2016) for venous thromboembolism indication, with no record of atrial fibrillation or recent cancer history, were observed until the occurrence of each safety outcome (hospitalization for intracranial, gastrointestinal, urogenital or other bleeding), death or study end (December 2018; in Germany, December 2017). Crude incidence rates of each outcome per 100 person-years were computed. Overall, 44 737 rivaroxaban and 45 842 vitamin K antagonist patients were enrolled, mean age, 59.9-63.8 years. Incidence rates were similar between rivaroxaban and vitamin K antagonist users with some exceptions, including higher incidence rates for gastrointestinal bleeding in rivaroxaban users than in vitamin K antagonist users. Among rivaroxaban users, mortality and bleeding risk generally increased with age, renal impairment and diabetes. This study provides further data from routine clinical practice that broadly support safety profile of rivaroxaban for VTE indication and complement findings from previous randomized clinical trials.

Tectonic Evolution of the Condrey Mountain Schist: An Intact Record of Late Jurassic to Early Cretaceous Franciscan Subduction and Underplating

AbstractThe Klamath Mountains in northern California and southern Oregon are thought to record 200+ m.y. of subduction and terrane accretion, whereas the outboard Franciscan Complex records ocean‐continent subduction along the North American margin. Unraveling the Klamath Mountains' Late Jurassic history could help constrain this transition in subduction style. Key is the Mesozoic Condrey Mountain Schist (CMS), comprising, in part, a subduction complex that occupies a structural window through older, overlying central Klamath thrust sheets but with otherwise uncertain relationships to more outboard Klamath or Franciscan terranes. The CMS consists of two units (upper and lower), which could be correlated with (a) other Klamath terranes, (b) the Franciscan, or (c) neither based on regional structures and limited extant age data. Upper CMS protolith and metamorphic dates overlap with other Klamath terranes, but the lower CMS remains enigmatic. We used multiple geochronometers to constrain the timing of lower CMS deposition and metamorphism. Maximum depositional ages (MDAs) derived from detrital zircon geochronology of metasedimentary rocks are 153–135 Ma. Metamorphic ages from white mica K‐Ar and Rb‐Sr multi‐mineral isochrons from intercalated and coherently deformed metamafic lenses are 133–116 Ma. Lower CMS MDAs (<153 Ma) predominantly postdate other Klamath terrane ages, but subduction metamorphism appears to start before the earliest coherent Franciscan underplating (ca. 123 Ma). The lower CMS thus occupies a spatial and temporal position between the Klamath Mountains and Franciscan and preserves a non‐retrogressed record of the Franciscan Complex's early history (>123 Ma), otherwise only partially preserved in retrogressed Franciscan high grade blocks.

The Utilization of Ternate Oral Tradition for The Identification of Potential Disasters

Oral traditions, as an integral part of a society's belief system, not only serve as a guide for society in daily life, such as interactions between members of society and other people, and even with nature or the environment, but they also serve as recorders of history and culture, including natural events. This paper aims to describe the oral traditions of Ternate to identify potential natural disasters that hit Ternate City in particular and North Maluku in general. Therefore, the author uses the theory of myth function to embody the main research problem. The approach used in this paper is semiotics, especially in interpreting natural disasters that occurred in the past through codes contained in oral stories or legends. The research results show that the people of Ternate can only explain a few natural events in the past. Then, it is ontologically digested into myth to symbolise the cosmic-mystical realm of thought. Apart from that, the results of this reflection are related to cause-and-effect events, give rise to rules of behaviour, and become local intellectual ideals. However, records of natural phenomena or past events in myths or legends can, in theory, be linked to the truth and thus make cycles of disaster predictable. On the other hand, in a formal educational setting, this legend can be used to teach about mitigation. Legends about the mysterious origins of certain lakes are thought to include aspects of disaster or mitigation in Ternate.

Recording physiological history of cells with chemical labeling.

Recordings of the physiological history of cells provide insights into biological processes, yet obtaining such recordings is a challenge. To address this, we introduce a method to record transient cellular events for later analysis. We designed proteins that become labeled in the presence of both a specific cellular activity and a fluorescent substrate. The recording period is set by the presence of the substrate, whereas the cellular activity controls the degree of the labeling. The use of distinguishable substrates enabled the recording of successive periods of activity. We recorded protein-protein interactions, G protein-coupled receptor activation, and increases in intracellular calcium. Recordings of elevated calcium levels allowed selections of cells from heterogeneous populations for transcriptomic analysis and tracking of neuronal activities in flies and zebrafish.

Analyzing the machine Learning methods to predict Bitcoin Pricing

A cryptocurrency is a form of digital money that uses the blockchain technology and cryptography to protect the information about transactions and exchange made on the digital market. A cryptocurrency like Bitcoin consists of a big network that has many peers working on it and every peer has a record of the whole history that contains all the transactions that ever happened. Bitcoin is the most popular cryptocurrency. Bitcoin has attracted a lot of attention from individual and institutional investors. The purpose of this paper is to analyse the machine learning methods to predict Bitcoin pricing. Machine learning and its associated fields have made notable advances in recent years. Machine learning techniques is used in different areas of science particularly cryptocurrency price forecasting. Using this machine learning model, we can predict the price direction of Bitcoin. Machine learning methods have been demonstrated to be effective in predicting bitcoin prices. Few machine learning models to predict the Bitcoin price are Linear Regression, Logistic Regression, Bayesian Regression, Support Vendor Machine, Random Forest, Neural Network were discussed. Every method of machine learning has its own advantages and disadvantages, however from the literature analysis it is understood that the Artificial Neural Network and Support Vendor Machine have the highest effectiveness rate. Machine learning methods have higher prediction accuracy than parametric regression approaches.

Hepatocyte growth factor as indicator for subclinical atherosclerosis.

Background: Hepatocyte growth factor (HGF) is a pleiotropic cytokine mainly produced by mesenchymal cells. After endothelial damage by oxidized low-density lipoprotein (LDL), HGF is produced and released into the circulation in response. Due to this mechanism HGF has been proposed as possible clinical biomarker for clinical as well as subclinical atherosclerosis. Patients and methods: The conducted study is an observational, single centre, cohort study, including 171 patients with at least one cardiovascular risk factor or already established cardiovascular disease (CVD). Each patient underwent 3D plaque volumetry of the carotid and femoral arteries as well as physical examination and record of the medical history. Additionally, plasma HGF and further laboratory parameters like high sensitivity C-reactive protein and LDL-cholesterol were determined. Results: 169 patients were available for statistical analysis. In bivariate correlation, HGF showed a highly significant correlation with total plaque volume (TPV, r=0.48; p<0.001). In receiver operating characteristic (ROC) analysis for high TPV, HGF showed an area under the curve (AUC) of 0.68 (CI 95%: 0.59-0.77, p<0.001) with a sensitivity of 78% and a specificity of 52% to predict high TPV at a cut-off of 959 ng/ml. In the ROC-analysis for the presence of CVD, HGF demonstrated an AUC of 0.65 (95% CI 0.55-0.73; p=0.01) with a sensitivity of 77% and a specificity of 52%. Conclusions: Higher plasma levels of HGF are associated with higher atherosclerotic plaque volume as measured by 3D-ultrasound.

The Age and Evolution of Lunar Micro Cold Traps at the Scale of Surface Exploration

AbstractCold traps are locations on the Moon that are shielded from sunlight where volatiles such as water could accumulate and persist against sublimation for geologic timescales. We model how long it takes accumulating craters to produce and then obliterate sub‐kilometer scale cold traps. Sub‐meter cold traps are extremely ephemeral, evolving in and out of existence over less than a few thousand years; however, larger 100 m to 1 km‐scale cold traps may persevere for geologic timescales and preserve a record of the volatile history of the Moon.

Rancang Bangun Sistem Informasi Kepegawaian Berbasis Web

BUM Desa Podho Joyo Sukorejo has an integrated information system in 1 website application, starting from HR, operations, and finance. However, the staffing information system is still less effective and efficient. The purpose of this research is to comprehensively describe the design of the staffing information system implemented at BUM Desa Podho Joyo Sukorejo. The solution that can be applied to overcome this problem is to develop a website-based staffing information system. The process of designing this system is done through direct observation method to BUM Desa Podho Joyo Sukorejo to collect accurate staffing data. The author chose to apply the waterfall method, a model in the System Life Development Cycle (SDLC) that involves system analysis, design, coding, and testing in sequence. The programming language used in this system is PHP, using Bootstrap as a web design library and MySQL as a database server. After performing a series of steps, including observation, design, and system development, it can be concluded that this system can assist employee staff in carrying out real-time recording of personal data, attendance, work history, and performance evaluation that can be accessed by related parties.&#x0D;

The Multifaceted Interpretation of the Napoleon Image in European Literature

The developmental process of the Napoleonic Wars and their impact across different countries and levels find expression in popular literary creations, particularly highlighting the influence of the Napoleonic Wars on literary production. Novels, serving as keen observers of life and meticulous recorders of history, embed their narratives within a macro-historical context, employing highly flexible and multidimensional narrative tones. In doing so, these novels illuminate historical events and characters, allowing them to radiate the brilliance of their lives once again. This paper takes "The Red and the Black" and "War and Peace" as case studies, using the events and impact of the Napoleonic Wars as examples to discuss the multifaceted interpretations of the same historical events in different European literary works.

Lithofacies, petrography, and geochemistry of the Lamphun oceanic plate stratigraphy: As a record of the subduction history of Paleo-Tethys in Chiang Mai-Chiang Rai Suture Zone of Thailand

Lithofacies, petrography, and geochemistry of the Lamphun oceanic plate stratigraphy: As a record of the subduction history of Paleo-Tethys in Chiang Mai-Chiang Rai Suture Zone of Thailand

The Significance of Suffering in Purifying the Faith of Believers Based on 1 Peter 1:6-7

Suffering is a feeling or a phase in which a person or group of people feels pain, difficulties and probems. In the history of Christianity, there have been many times when Christians have been persecuted by various parties, be it from the government or the surrounding environment. History record that in 64 Ad massive persecution was aimed at Christians led by Emperor Nero. However, it is not only history that, in fact, in today’s modern era, Christianity still receives persecution, suffering or pressure from vaiorus parties. In this study the authors used a descriptive method whih is a method to provide an overview of the state of an object in the present but based on existing facts then provide analysis and interpretation. This research aims to provide an understanding that in every problem, suffering and persecution is not to weaken the Christian faith, because true Christianity that can stand the test under any circumstances. So it can be concluded that suffering brings purity of faith in God and at the same time makes us more in a relationship with God.

Long Cycle Life Rechargeable Moisture‐Enabled Electricity Cell

AbstractMoisture‐enabled electricity generation (MEG) is a prominent renewable energy harvesting technology in hydrovoltaic power generation, boasting the broadest energy harvesting spectrum. However, practical application faces limitations due to irreversible performance degradation caused by structural changes and moisture‐generated carrier (MGC) losses in Moisture‐enabled electricity (ME) materials, rendering them non‐renewable. This study introduces a rechargeable moisture‐enabled electricity cell (rMEC) based on dual ME functional layers and active metal electrodes. The rMEC demonstrates outstanding power generation performance, with a single cell providing an output voltage of 1.08 V and a power density of 5.83 µW cm−2 through redox assistance. Moreover, it can be recharged when MGCs are lost, utilizing the reversibility of the redox reaction (moisture of H2O2 solution) for self‐repair. Notebly, the rMEC maintains stable operation for over 2080 h and undergoes 100 charging/working cycles, marking the longest span life record in MEG research history. When exposed to industrial wastewater/gases with oxidation characteristics, the rMEC not only completes charging but also facilitates the reuse of toxic waste resources. The environmentally friendly rMEC, with its long cycle life, significantly overcomes the limitations of non‐renewable ME materials, serving as a paradigm for promoting iterative upgrades in MEG technology.

Learning While Doing

In Spring 2023, Dr. Wendy Soltz's Introduction to Public History class at Ball State University in Muncie, Indiana worked directly with the public by preparing for and conducting oral histories. The project was a collaboration between the Public History Program, Fort Wayne Historic Preservation, Neighborhood Planning &amp; Activation, and Parks Departments, and the Jennings Center. Students worked with Fort Wayne City staff to develop questions and learn about the project from the “client’s” point of view and to learn about the history of the center and oral history best practices. The resulting oral history recordings help to document the life of the Center and its impact on the East Central Neighborhood of Fort Wayne, Indiana. This article provides the perspectives of three students in the class and the unexpected learning that took place while doing public history.

홍무제의 공민왕 책봉 조서의 實在

This paper start with the record of the arrival of Ming's envoy in May of the 19th year of King Gongmin(1370) to officially appoint King Gongmin as the King of Goryeo, and try to find and give meaning to the record of the cefeng(冊封) of King Gongmin while keeping in mind the situation of the early formation of the Goryeo-Ming relationship. In the Goryeo history, only the existence of gaoming(誥命) appears as a document delivered when King Gongmin was appointed as King of Goryeo by Emperor Hongwu(洪武). And in the records of the Ming side, the same content of gaoming is transmitted in almost the same form of Goryeo history with only some characters changed. The problem is that the Ming records are subtly different. While Veritable Record of Ming Taizu records both the royal edict(詔書) and the gaoming to appoint King Gongmin, the actual content of the royal edict was identical to the edict to appoint King Wu of Goryeo. In other words, the royal edict sent to appoint King Wu was mistakenly recorded as the edict sent to appoint King Gongmin. As a result, it is difficult to determine with certainty whether Emperor Hongwu sent only the seal and the gaoming, or both the edict and the gaoming, when he appointed King Gongmin.&#x0D; However, this paper have found that there is a royal edict of Emperor Hongwu that is similar in overall content to the gaoming but different in text, and this paper assumes that it is the royal edict that was issued at the time of the King Gongmin's appointment. This document, which was included in the collection of Wanghui(王褘), a literary bureaucrat who served under Emperor Hongwu from the late 1350s, can be used as evidence to support the existence of a document for the cefeng of King Gongmin apart from the gaoming for the appointment of King Gongmin. In the end, it can be assumed that Emperor Hongwu sent the royal edict, gold seal, and gaoming together when he appointed King Gongmin as King of Goryeo as recorded in the Veritable Record of Ming Taizu.&#x0D; However, it is unclear why this document is only found in the collection of Wanghui and not at all in records compiled by the state, such as the Goryeo History or Veritable Record of Ming Taizu. Whether this was an intentional omission or a mistake on both sides, or whether the document was only recorded in a collection of documents and never actually delivered to Goryeo, remains to be seen. It is hoped that future advances in the study of Goryeo-Ming relations and further research will shed light on many of these questions.

2670. Sexual Health Evaluation Among People Tested for Mpox in an Urban Health System

Abstract Background The predominant mode of transmission in the 2022 mpox outbreak was sexually associated. Best practices for mpox evaluation include a sexual history, an anal and/or genital exam and STI testing. We hypothesized that the quality of clinical evaluation (QoC) for mpox varied by clinical setting. Methods A retrospective chart review was conducted on all patients in the Johns Hopkins Health System (JHHS) who tested for mpox from June 15 through December 15, 2022. Outcome measures included three QoC metrics (record of sexual history, anal and/or genital exam and concomitant STI testing). Fisher’s exact test was used to compare the frequency of QoC indicators by location of mpox testing (emergency department/urgent care [ED/UC], HIV/sexual health clinic [HIV/SH] or non-HIV/SH outpatient clinic [non-HIV/SH]). Results Of 269 patients tested for mpox, median age was 37 years, 48% were Black, 8% Latino, 71% assigned male sex at birth, 2% transgender women and 25% living with HIV (Table 1). Location of mpox testing was ED/UC (n=165), HIV/SH (n=50), or non-HIV/SH (n=54). Rates of mpox diagnosis and documentation of a sexual history, anal and/or genital exam and concomitant STI testing varied by site and were statistically significantly different (Table 2). HIV/SH had the highest rate of mpox test positivity (58%) and were most likely to meet these QoC indicators (96%, 78% and 82%, respectively) followed by ED/UC (74%, 50%, 57%, respectively) and HIV/SH clinics (68%, 32%, 30%). Conclusion In a high-volume tertiary care health system, only 50% of individuals tested for mpox had a documented anal and/or genital exam and 57% had concomitant STI testing. QoC indicators for mpox evaluation were highest in clinics where sexual health assessments are routine (HIV/sexual health), intermediate in ED/urgent care settings and lowest in non-HIV/sexual health settings. These findings support other studies that demonstrate a lack of consistent sexual health evaluation among individuals at risk for STIs. Strategies that decrease barriers to completed sexual history, exam and STI testing should be explored including audio-computer assisted patient report of sexual history, patient self-collection of STI testing and provider training. Disclosures Matthew M. Hamill, MBChB, PhD, Roche diagnostics: Honoraria Kelly Gebo, MD, MPH, Pfizer: Advisor/Consultant|Spark HealthCare: Advisor/Consultant

Medication adherence management for in-home geriatric care with a companion robot and a wearable device

Older adults are prone to forgetfulness and varying degrees of cognitive impairment, which can lead to not taking medication on time, taking the wrong medication or the wrong dose, all of which can negatively affect a person’s health and recovery from illness. Existing medication reminders, like mobile apps and pill boxes, are neither age-friendly nor designed to minimize the burden of documenting medication adherence. In this paper, we present a Medication Adherence Management System (MAMS) for elders, which is based on a companion robot and a wearable device. The MAMS addresses the key issues of safe medication management: medication reminders, medication confirmation, and medication history recording. Human subject tests were conducted to evaluate the performance, acceptability and usability of the MAMS. Results from 35 human subjects showed that the average scores of the convenience, usefulness, and adoptability of the proposed MAMS were 8.17, 8.49, and 8.23 out of 10, respectively. The System Usability Scale (SUS) scores for the MAMS, the robot, and the wearable device are 75.29, 78.60 and 76.40, respectively. We believe the MAMS has potential use in future in-home geriatric care.

Blockchain technology in Cardiovascular Medicine: a glance to the future? Results from a social media survey and future perspectives.

The leverage of digital facilities in medicine for disease diagnosis, monitoring, and medical history recording has become increasingly pivotal. However, the advancement of these technologies poses a significant challenge regarding data privacy, given the highly sensitive nature of medical information. In this context, the application of Blockchain technology, a digital system where information is stored in blocks and each block is linked to the one before, has the potential to enhance existing technologies through its exceptional security and transparency. This paradigm is of particular importance in cardiovascular medicine, where the prevalence of chronic conditions leads to the need for secure remote monitoring, secure data storage and secure medical history updating. Indeed, digital support for chronic cardiovascular pathologies is getting more and more crucial. This paper lays its rationale in three primary aims: 1) to scrutinize the existing literature for tangible applications of blockchain technology in the field of cardiology; 2) to report results from a survey aimed at gauging the reception of blockchain technology within the cardiovascular community, conducted on social media; 3) to conceptualize a web application tailored specifically to cardiovascular care based on blockchain technology. We believe that Blockchain technology may contribute to a breakthrough in healthcare digitalization, especially in the field of cardiology; in this context, we hope that the present work may be inspiring for physicians and healthcare stakeholders.

A ANALYSIS OF PREPARATIONS FOR THE IMPLEMENTATION OF ELECTRONIC MEDICAL RECORDS AT RSJ PROF HB SAANIN PADANG USING THE DOQ-IT METHOD

According to PMK No. 24 of 2022, a medical record is a document containing data on patient identity, examination, treatment, actions, and other services that have been provided to the patient. Through this policy, health service facilities are required to run an electronic patient medical history recording system. The transition process is carried out until no later than 31 December 2023. This type of research uses quantitative methods. Quantitative research methods are used to determine the picture of hospital readiness. The method used to analyze hospital readiness is DOQ-IT with indicators of organizational culture readiness, governance and leadership readiness, human resource readiness, and infrastructure readiness. Based on the results of the research that has been carried out, information can be obtained that in the aspects of human resources, organizational work culture, leadership governance, and infrastructure as a whole can be seen from the answers of 18 ready respondents (46.06%) and very ready as many as 20 people (49.87%) then with the respondent's answer not ready as many as 1 person (2.22%) the answer is very unprepared as many as 1 person (0.35%) and for the answer hesitant as many as 1 person (1.44%), it is confirmed from the informant that the preparation for the implementation of electronic medical records is ready to be implemented.

Photoirradiation‐Gated Excitation‐Dependent Room‐Temperature Phosphorescence in Through‐Space Charge Transfer Molecules

AbstractOrganic materials showing reversible changes in persistent room‐temperature phosphorescence (RTP) upon exposure to external stimuli have attracted considerable attention in recent years. One potentially groundbreaking development in this area is the introduction of the gating concept for organic persistent RTP materials. This refers to a material where a desired responsive ability only occurs when it is triggered by a specific stimulus, but it remains a formidable challenge. In this study, photoirradiation‐gated excitation‐dependent (Ex‐De) persistent RTP is achieved. A series of molecules, triphenylphosphine and carbazole derivatives connected through flexible carbon chains, are designed and prepared. Upon removal of ultraviolet (UV) irradiation, all these compounds doped polyvinyl alcohol (PVA) films exhibit obvious blue or green afterglow RTP. Among them, (2‐(9H‐[3,9′‐bicarbazol]−9‐yl)ethyl)triphenylphosphonium bromide (TPP‐2C‐Cz) doped PVA film initially exhibits blue persistent RTP after removal of 300 nm excitation but no RTP upon ceasing 365 nm irradiation. Interestingly, upon UV irradiation with a power density of 0.05 W cm−2 (UVA) for 50 min, the Ex‐De RTP behavior of TPP‐2C‐Cz doped PVA film is activated. Eventually, photoirradiation‐gated Ex‐De afterglow emission will be used for a wide range of applications, including the quantitative determination of UV irradiation dose and the permanent record of UV irradiation history, and read on‐demand.

EVALUATION AND MANAGEMENT OF POSTPARTUM HYPERTENSION IN A TERTIARY CARE HOSPITAL

Objective: The objective is to study the causative factors of postpartum hypertension (PPHTN), time taken for control of blood pressure (BP) in postpartum period and to study the anti-hypertensive drugs used in control of PPHTN. Methods: The study was conducted for 1½ years. During the study, 190 women in postpartum period with high BP were enrolled in the study. A detailed record of history and general physical examination and local examination was done as per pro forma after written informed consent. Results: Out of 190 subjects, 168 had a history of hypertension (HTN) in the antenatal period, and the rest 22 went on to develop HTN in the postpartum period. Gestational HTN and preeclampsia were the most frequent types of hypertensive disorders seen among subjects. In 42.1% of patients, PPHTN developed after 48 h and in 23.7% of cases developed within 48 h. BP normalized post-delivery in 22.6% of subjects. The majority (74.1%) of subjects took tablet labetalol post-delivery. 62.1% of patients took anti-hypertensive for more than 7 days and were discharged on treatment with advice to follow-up. 15.3% took treatment for &lt;7 days. No treatment was required by 22.6% of subjects. Conclusion: Our data identified a high prevalence of PPHTN. We found a significant correlation between the levels of severity of antepartum BP with the level of severity of postpartum BP. Monitoring of HTN is important in the postpartum period for all patients as the majority develop hypertension after 48 h.