To apply the yields in the reference materials to patient cases, a biunique conversion of the elemental composition of human tissues to a composition from the reference materials has been established. Since the measured yields do not contain any information on the lateral properties of the beam, a model for the spread caused by multiple Coulomb scattering in thick targets [3] has been implemented. The width of the beam as provided by the accelerator is taken from the accelerator beam parameters. Furthermore, an extended analytical model for the positron range distribution around the emitting isotopes has been included in the software [4]. For comparison in-beam PET measurements were used, which were acquired by means of a detector system installed at the irradiation site in the framework of the carbon therapy project at GSI Helmholtzzentrum fur Schwerionenforschung [5]. Results: Figure 1 shows the measured activity distribution (a), the conventional condensed history MC simulation (b) and the yield based simulation (c) of a patient suffering from a skull base tumor in coronary view. The iso-activity lines have a distance of 10%. The PTV is shown in pink. The yield based simulation produces a reasonable activity distribution. Compared to the conventional code, a superior accordance is observed.