Utilizing identical sampling and analytical techniques, the morphological and chemical characteristics of a modern Vertisol (Houston Black series, central Texas) can be directly compared with an Upper Mississippian paleo-Vertisol from the Appalachian basin (Pennington Formation, east-central Tennessee). Mass-balance reconstructions suggest retention of primary pedochemical patterns in the paleo-Vertisol, including patterns of soil volume change (strain) and transport functions (translocations) of many major and trace elements. Retention of primary pedochemical patterns suggests that Vertisols constitute nearly closed systems during burial diagenesis. Chemical and mineralogical changes associated with burial diagenesis of the paleo-Vertisol include oxidation of organic carbon (OC), illitization of smectites, dehydration and recrystallization of Fe–Mn oxyhydroxides, and dolomitization of pedogenic calcite. Significant differences in the chemical behavior of gilgai microhigh and microlow pedons in modern Vertisols have implications for interpretation of geochemical data obtained from paleo-Vertisols. Overall wetter soil conditions and variable redox potential under gilgai microlows promote greater depths of leaching and mobility of redox-sensitive trace elements, including Co, Cr, Cu, Mn, Ni, and V. Gilgai microhighs behave as evaporative “wicks” that draw moisture and soluble phases towards the soil surface, resulting in precipitation of metal hydrosylate complexes and sulfates (gypsum) at the capillary fringe and shallower depths of leaching and fixation of trace elements. Paleoprecipitation estimates from paleosols, based on the depth to the top of the pedogenic carbonate horizon, should therefore utilize field, petrographic and geochemical data for characterizing maximum depths of leaching, loss or gain of exchangeable bases, and calcification, rather than relying solely upon field data.