The indications for and the results of 60 consecutive microvascular bone transfers performed at our institution during a 50-month period are reviewed. All 60 patients were followed up for at least 1 year. The overall primary union rate was 67%, and the eventual union rate was 77%. The most frequent indication for the procedure was long-bone reconstruction after limb-salvage wide local resection of a malignant tumor. We achieved the best results with limb reconstruction after resection of a malignant tumor and with recipient sites that involved the forearm or mandible. In contrast, our results were least favorable with reconstruction after resection for chronic osteomyelitis and with reconstruction of defects of the shoulder girdle. Overall, vascularized bone transfer seems to be a valuable reconstructive technique for management of clinical problems that involve massive skeletal defects.