• A coating consist of MnO 2 nanoenzyme and Sr ions was fabricated on Ti implant. • MnO 2 nanoenzyme alleviated OA and O 2 deficiency at the injury site. • Sr ions released from the surface of implant promoted the growth of MSCs. • The modified Ti implant significantly accelerate bone regeneration in vivo . Bone injury and implantation operation are often accompanied by microenvironment damage of bone tissue, which seriously affects the process of osseointegration of implants, especially for titanium (Ti)-based bioinert materials. Thus, repairing or improving the microenvironment of damaged bone tissue is of great significance for bone rescue, reconstruction, and regeneration still a major medical challenge. Oxidative stress (OS) and oxygen (O 2 ) deficiency are considered to be specific physiological signals of the bone-injury microenvironment. From the above background, a coating consisting of manganese dioxide (MnO 2 ) nanoenzyme and strontium (Sr) ions was fabricated on the surface of the Ti implant via a one-step hydrothermal treatment. MnO 2 nanoenzyme presented in the coating alleviated OS and O 2 deficiency at the injury site by catalyzing the decomposition of abundant endogenous H 2 O 2 around the modified Ti implants into O 2 . In addition, Sr ions were released from the surface of the implant at a certain rate in a body-fluid environment, further promoting the adhesion, growth, and osteogenic differentiation of mesenchymal stem cells. More importantly, a Sprague Dawley rat femur model demonstrated that the modified Ti implant showed significant potential to accelerate bone tissue reconstruction in vivo . In summary, the present system provides a new idea for the treatment of bone injury and the development of new orthopedic implants.