The purpose of this paper is to assess supply chain reconfigurability in a global scenario. The paper attempts to measure comprehensive relative reconfigurability index (CRRI) in an automobile case supply chain by holistically considering fifteen enablers of reconfigurability. The present research evaluates CRRI by utilizing two distinct assessment models that calculate relative reconfigurability index (RRI). Firstly, a deterministic assessment model is developed from the total interpretive structural modeling (TISM) digraph, and secondly, an integrated assessment methodology that utilizes both the Delphi technique and the additive weighting method to calculate RRI. The uniqueness of the present research is to quantify reconfigurability in the case supply chain by a numerical index termed as CRRI. The paper analyzes the level of reconfigurability competence of the case supply chain in comparison with an ideal supply chain and thus facilitates structural flexibility. The proposed model for calculating CRRI, using two methodologies and comparing the results, is an innovative way of measuring supply chain reconfigurability. Supply chain’s preparedness to structurally change in the present business environment of uncertainty and turbulence can be evaluated and it would act as an aide in decision making pertaining to reconfigurability in supply chains.