A field experiment was conducted during late kharif season of 2018–2019 at College of Horticulture, Anantharajupeta to evaluate the effect of different organic manures and bio- fertilizers on growth and yield of senna cv. Sona. Vegetative growth parameters like plant height (87.26 cm), number of branches (17.40), dry matter production (0.867 kg m−2) and crop growth rate (15.22 g m−2 d−1) were found maximum by application of 100 per cent recommended dose of nitrogen (RDN) through urea and was found at par with the application of 100% RDN through vermicompost in combination with bio-fertilizers. Number of days required for 50% flowering, total number of leaves, leaf area (cm2), total chlorophyll content (SCMR values) and stem girth were found significantly maximum by application of 100% RDN through vermicompost in combination with biofertilizers and was found at par with 100% RDN through urea. Specific leaf weight and leaf weight ratio were found nonsignificant among the treatments. Cumulative leaf yield was found significantly highest by application of 100 per cent RDN through vermicompost in combination with bio-fertilizers. However, significantly highest leaf yield and pod yield in senna at 115 and 140 DAS was recorded by application of 100% RDN through urea and was found at par with 100% RDN through vermicompost in combination with bio-fertilizers.