Sesame (Sesamum indicum L.) is an important cash crop and plays a vital role in many people's livelihoods in Ethiopia. However, its production is low due to many constraints, and low soil fertility is among the major. The previous fertilizer recommendation was a blanket recommendation regardless of the soil fertility status. Hence, the objective of this review is to synthesize the different recommendations and forward to the sesame growing areas. R statistical software and Python programming language used to analyze the chemical and physical soil properties, association among the chemical and physical soil properties and association with soil depth. The organic carbon, total N (Nitrogen), available P (Phosphorus), S (Sulfur) and Zn (Zinc) are below optimum value while K is sufficient in the soil and moderately alkaline soil. The soil particle size is dominantly clay (58.5%). The clay particle size and pH increased while the sand and silt particle sizes, organic carbon, total N, available P and S decreased as the soil depth increased. 204,558.8 ton of sesame stack residue are burned every year, and from this, 7360.03 ton of NPK is lost every year in Western Tigray. The recommended N, P and S for sesame are: (i) 64 and 41kgha -1N for low N content areas and for medium N content areas respectively; 46 and 23kgha -1 P2O5 for low and medium P content areas; (iii) 60 and 30kgha -1S for low medium S content areas may be recommended to boost sesame production.
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