Doctor's Recommendation Research Articles

Experiences of patients with hard-to-heal wounds: insights from a pilot survey.

To learn about the experiences of people who seek treatment for hard-to-heal wounds, we distributed a nationwide pilot survey, asking questions about the nature of their wound, how it shaped their daily lives, pathways to receiving care and experiences with treatment. The long-term objective is to quantify the journey of patients with hard-to-heal wounds to identify ideal intervention points that will lead to the best outcomes. This article summarises the findings, implications, limitations and suggestions for future research. Qualitative data were self-reported from patients with hard-to-heal wounds (open for ≥4 weeks) in a pilot chatbot survey, (Wound Expert Survey (WES)) provided online in the US on Meta platforms (Facebook and Instagram) between 2021 and 2022. The US national pilot survey attracted responses from 780 patients, 27 of whom provided a video testimonial. Some 57% of patients delayed treatment because they believed their wound would heal on its own, and only 4% saw a wound care specialist. Respondents reported the cost of care as the most frequent reason for not following all of a doctor's treatment recommendations. Queries regarding quality of life (QoL) revealed that more than half (65%) said they have negative thoughts associated with their wound at least every few days. Some 19% of respondents said their wound had an odour and, of them, 34% said odour had a major or severe negative impact on their self-confidence. Economically, nearly one-quarter of respondents said having a wound led to a drop in their total household income and 17% said their wound led to a change in their employment status. A national pilot survey of patients with hard-to-heal wounds revealed that many delay seeking professional assistance and only a small minority see a wound care specialist. Experiencing an ulcer, even for a few months, can have significant negative effects on a patient's QoL. Patients frequently had negative thoughts associated with their wound, and odour compounded these negative effects, leading to major or severe negative impacts on self-confidence. Households experienced a decline in income, due to both the direct reduction or loss of patient employment and the additional time spent by family members assisting in patient recovery. Thus, a variety of factors contribute to poor outcomes for patients with hard-to-heal wounds. To validate and extend these preliminary results, future surveys of patients with hard-to-heal wounds should focus on additional reasons patients do not seek professional help sooner. To improve health outcomes and QoL, assessment of patient socioeconomic variables should occur whenever wound closure stalls.

Algorithm Identification and Integrated with Push Service for Telemedicine System

Telemedicine systems, while overcoming physical space constraints, often lack personalized interactions. By incorporating a push service and leveraging prediction-oriented algorithms, these systems can offer an improved user experience. Such enhancements enable timely treatment options and reduce unnecessary resource usage in on-site outpatient clinics. This research work starts by creating a robust algorithm using data mining techniques. Next, it establishes the foundation for a telemedicine push service. The service includes essential modules for disease differentiation, doctor recommendations, and diagnosis predictions. To optimize these modules, a merged algorithm combining k-nearest neighbor classification, nearest neighbor recommendation, and FP-growth is needed. This work aims to enhance treatment options for patients and streamline resource usage in on-site outpatient clinics. Moreover, this work has carried out empirical research for identification of algorithm by using available data at a public Chinese telemedicine system. The results of data analysis show the follows: 1. For disease diagnosis, the KNN model (k=1) is more accurate but less efficient, SVM and LibSVM are more efficient but less accurate than the KNN model; 2. In terms of doctor recommendation, nearest neighbor recommendation performs better but is not as efficient as matrix factorization; 3. in diagnostic prediction, the combination of introducing association mining and data segmentation can play a better role. The developed algorithm and its conclusions from this study could make easier and more efficient to provide treatment options for undecided-condition patients.

A Study on Doctor Recommendation Model in Medical Guidance Services

In medical guidance services, it is of great significance to match the appropriate department and doctor by digging deeper into patients’ demands. However, accurate matching of doctors requires the ability to locate the exact department based on the text of the patients’ chief complaint, and then select the matching doctor by considering the patients’ condition, the doctor’s professionalism, and the patients’ preference. To this end, this paper proposes a department classification model on the basis of Convolutional Neural Networks (CNN) as well as Robustly optimized BERT approach (RoBERTa) with an attention mechanism. The model firstly extracts the patients’ chief complaint texts features by convolution layer, and then introduces the attention mechanism to assign different weights to different features. Subsequently, these features are fused with the features extracted by RoBERTa for classification. In addition, this paper proposes a doctor recommendation algorithm that considers both patient similarity and patient preference. Through the in-depth analysis on the patients’ condition claims, various weights are assigned to various influencing factors, and then the matching degree is calculated to achieve the accurate recommendation of doctors. The experimental results reveal that the proposed department classification model’s accuracy on the dataset is 93.4%, and the Normalized Discounted Cumulative Gain (NDCG) of the doctor recommended algorithm is 90.7%. In this way, the proposed model effectively improves patient-doctoral matching with excellent performance.

Are HPV Vaccines Well Accepted among Parents of Adolescent Girls in China? Trends, Obstacles, and Practical Implications for Further Interventions: A Five-Year Follow-Up Study.

In 2020, the WHO proposed the global strategic goal of accelerating the elimination of cervical cancer (CC). One of the key strategies is that, by 2030, 90% of girls will complete HPV vaccination by age 15. In 2017, HPV vaccines were first marketed in China. This study aimed to explore the changes in parents' knowledge about CC, HPV, HPV vaccines, and acceptance of HPV vaccination 5 years after the introduction of HPV vaccines into China. Associated factors and reasons for refusal by parents were also explored. A school-based follow-up study was conducted among parents in China from May 2018 to May 2023. Comparison using Chi-square tests was performed to measure the changes. Univariate and multivariate analyses were used to explore factors associated with HPV vaccination among teenage girls. The overall cognitive level in terms of CC- and HPV-related knowledge among parents increased, and they expressed more willingness to vaccinate their daughter (35.4% in 2018 vs. 56.6% in 2023). The HPV vaccination rate among teenage girls remained at a low level (4.4% in 2018, 9.8% in 2023). The main obstacles reported by parents were limited knowledge (42.0%), scarcity of the HPV vaccine (29.2%), waiting until their daughter was older (27.5%), safety concerns (14.7%), high cost (9.0%), and effectiveness concerns (4.6%). Parents who are elderly, local residents, have received HPV vaccines themselves, have had experience of vaccinating their children with influenza vaccines, and have a higher knowledge level of CC, HPV and HPV vaccines are more likely to vaccinate their children with HPV vaccines. Although we observed an increment in parents' knowledge level in terms of CC, HPV, HPV vaccines, and HPV vaccine uptake over the past 5 years, the HPV vaccine coverage among girls still falls short of the WHO's 2030 target. Comprehensive intervention strategies, including tailored health education among adolescents and their parents, doctor recommendations, and providing financial subsidies or free HPV vaccines are needed in China.

RATIONAL AND IRRATIONAL USE OF ANTIDEPRESSANTS IN THE REGION OF TETOVO

The main purpose of this study is to analyze and evaluate the attitudes and practices of using antidepressants, herbal products for the treatment of depression, as well as raising awareness about the use of antidepressants among respondents in Tetovo and the surrounding area. The target population randomly selected for the study was females and males aged 18 to 57 years. The study was conducted through the survey process with the Google Questionnaire platform. The vast majority of respondents used antidepressant with a doctor's recommendation with a figure of 71%, where the majority of antidepressant users were female, while 29% used antidepressant without a doctor's recommendation. As pharmaceutical preparations most often used benzodiazepines for the treatment of depression which since these results as a recommendation should be taken to raise awareness of the population for the treatment of depression and not only for its simultaneous treatment. Regarding the period of use of antidepressants without a doctor's recommendation according to the patient's need is very large from the study done and measures should be taken to raise awareness among the population not to use at all without a doctor's recommendation and if used follow the instructions given by the doctor. The number of users of herbal products is very small and disturbing as most individuals choose to use benzodiazepines to manage their distressing symptoms and from this we can recommend raising awareness by pharmacists to patients when purchasing products and done a clarification on the use of herbal products as an alternative. From the study, the majority of respondents think that the use of antidepressants as needed has been effective and that they are aware of the side effects of use, which should result in a massive awareness of the population including doctors, pharmacists and patients about the use of antidepressants.

Use of Dietary Supplements among Polish Children with Inflammatory Bowel Disease: A Two-Center Pilot Study.

Inflammatory bowel disease (IBD) includes Crohn's disease (CD) and ulcerative colitis (UC). These diseases are characterized by inflammation, which may be a consequence of changes in the intestinal microbiota and lead to mineral and vitamin deficiencies. The aims of this study were to determine the level of dietary supplement intake in children with IBD and to determine the influence of factors such as sex, nutritional status, diet, and other comorbidities on supplement intake. The study was conducted from May 2022 to September 2023 and was a prospective study. The group of children with IBD that ultimately qualified for the study numbered 96, and the control group numbered 30. The children who participated in the study were aged 4-18 years. Most parents of children with IBD (81.4%) declared that they use supplementation for their children, while 75% of parents of children without IBD declared giving their children nutritional supplements. Vitamins in both groups were most often given to children as dietary supplements (p = 0.018), including vitamin D. Depending on the diet used, the intake of vitamin B6 (p = 0.018), vitamin E (p = 0.040) and iron (p = 0.006) was significantly different among children with IBD. Statistical significance (p = 0.021) was observed for supplementation use and disease stage among children with IBD. For 80.2% of parents of children with IBD, the main reason for using supplements was a doctor's recommendation. In the control group, 43.3% of parents indicated that the main reason for using supplements was to correct nutritional deficiencies. Supplementation was common in both groups, but attention should be paid to other current diseases in children with IBD and to nutritional status. In our opinion, educating parents about supplementation is important, especially among parents of children with IBD.

Novel Approach to Personalized Physician Recommendations Using Semantic Features and Response Metrics: Model Evaluation Study.

The rapid growth of web-based medical services has highlighted the significance of smart triage systems in helping patients find the most appropriate physicians. However, traditional triage methods often rely on department recommendations and are insufficient to accurately match patients' textual questions with physicians' specialties. Therefore, there is an urgent need to develop algorithms for recommending physicians. This study aims to develop and validate a patient-physician hybrid recommendation (PPHR) model with response metrics for better triage performance. A total of 646,383 web-based medical consultation records from the Internet Hospital of the First Affiliated Hospital of Xiamen University were collected. Semantic features representing patients and physicians were developed to identify the set of most similar questions and semantically expand the pool of recommended physician candidates, respectively. The physicians' response rate feature was designed to improve candidate rankings. These 3 characteristics combine to create the PPHR model. Overall, 5 physicians participated in the evaluation of the efficiency of the PPHR model through multiple metrics and questionnaires as well as the performance of Sentence Bidirectional Encoder Representations from Transformers and Doc2Vec in text embedding. The PPHR model reaches the best recommendation performance when the number of recommended physicians is 14. At this point, the model has an F1-score of 76.25%, a proportion of high-quality services of 41.05%, and a rating of 3.90. After removing physicians' characteristics and response rates from the PPHR model, the F1-score decreased by 12.05%, the proportion of high-quality services fell by 10.87%, the average hit ratio dropped by 1.06%, and the rating declined by 11.43%. According to whether those 5 physicians were recommended by the PPHR model, Sentence Bidirectional Encoder Representations from Transformers achieved an average hit ratio of 88.6%, while Doc2Vec achieved an average hit ratio of 53.4%. The PPHR model uses semantic features and response metrics to enable patients to accurately find the physician who best suits their needs.

Evaluation of AI-Driven LabTest Checker for Diagnostic Accuracy and Safety: Prospective Cohort Study.

In recent years, the implementation of artificial intelligence (AI) in health care is progressively transforming medical fields, with the use of clinical decision support systems (CDSSs) as a notable application. Laboratory tests are vital for accurate diagnoses, but their increasing reliance presents challenges. The need for effective strategies for managing laboratory test interpretation is evident from the millions of monthly searches on test results' significance. As the potential role of CDSSs in laboratory diagnostics gains significance, however, more research is needed to explore this area. The primary objective of our study was to assess the accuracy and safety of LabTest Checker (LTC), a CDSS designed to support medical diagnoses by analyzing both laboratory test results and patients' medical histories. This cohort study embraced a prospective data collection approach. A total of 101 patients aged ≥18 years, in stable condition, and requiring comprehensive diagnosis were enrolled. A panel of blood laboratory tests was conducted for each participant. Participants used LTC for test result interpretation. The accuracy and safety of the tool were assessed by comparing AI-generated suggestions to experienced doctor (consultant) recommendations, which are considered the gold standard. The system achieved a 74.3% accuracy and 100% sensitivity for emergency safety and 92.3% sensitivity for urgent cases. It potentially reduced unnecessary medical visits by 41.6% (42/101) and achieved an 82.9% accuracy in identifying underlying pathologies. This study underscores the transformative potential of AI-based CDSSs in laboratory diagnostics, contributing to enhanced patient care, efficient health care systems, and improved medical outcomes. LTC's performance evaluation highlights the advancements in AI's role in laboratory medicine.

A Review on Consumer Patterns and Behaviours’ Towards Generic Medicines

Generic medicines have become an important topic in healthcare due to their potential to reduce costs while providing equivalent treatment to branded drugs. This review article investigates consumer patterns and behaviors related to generic medicines, focusing on awareness, purchasing factors, and satisfaction levels. The research employs a systematic literature review methodology, analyzing peer-reviewed journals, government reports, and industry studies on generic medicines and consumer behavior. Various statistical techniques, such as percentage analysis, chi-square tests, factor analysis, Garrett ranking, and Likert scales, are used to summarize demographic profiles, examine relationships, identify influencing factors, prioritize purchase constraints, and measure satisfaction levels. Key findings reveal that consumer awareness of generic medicines varies widely, influenced by factors such as age, education, and exposure to information from healthcare providers. Government initiatives like India's Pradhan Mantri Jan Aushadhi Yojana aim to increase access to affordable generics, yet awareness remains limited in some areas. Price is a major motivator for purchasing generics, but other factors like perceived quality, doctor recommendations, availability, and prior experience also play significant roles. Generally, consumers express positive experiences with generics, citing effectiveness, cost savings, and quality. However, some consumers and healthcare providers harbor concerns about the safety and efficacy of generics compared to branded versions. This review underscores the need for ongoing efforts to enhance consumer confidence in generics through education and awareness campaigns, ensuring the success of initiatives aimed at making essential medicines affordable and accessible to all.

Degree of compliance with doctors recommendations and its effect on compensation of the disease among children and adolescents with congenital adrenal hyperplasia

Degree of compliance with doctors recommendations and its effect on compensation of the disease among children and adolescents with congenital adrenal hyperplasia

How do recommendations influence patient satisfaction? Evidence from an online health community

PurposeThis study aims to explore whether seeking recommendations for doctors from offline word-of-mouth or online reviews influences patient satisfaction after treatment, and how the source of recommendation affects this effect.Design/methodology/approachUsing a unique dataset of more than three million reviews from a popular Chinese online health community, this study used the coarsened exact matching method and built fixed-effect models to conduct empirical analysis.FindingsThe results suggest that selecting doctors according to recommendations can improve patient satisfaction and mitigate their dissatisfaction when encountering service failures. However, online recommendations were found to be less effective than offline sources in improving patient satisfaction.Originality/valueThis study provides important insights into patient satisfaction and doctor-patient relationships by revealing the antecedents of satisfaction and the potential for improving this relationship. It also contributes to the understanding of how recommendations in the healthcare context can improve patient satisfaction and alleviate the negative impact of service failures.

Assessment and management of allergic rhinitis: A review and evidence-informed approach for family medicine.

Allergic rhinitis is an inflammatory disorder affecting nasal mucosa in response to al-lergen exposure and is commonly assessed and managed in family medicine. In this article, we review new international guidelines on the diagnosis and management of allergic rhinitis and generate evidence-informed recommendations for family medicine doctors.

Infection Prevention and Control in the Emergency Department Unit in King Khalid Hospital, Hail City, Saudi Arabia

Context: The emergency department presents unique challenges to infection control and prevention. Infection control (IC) activities include the identification of infectious disease processes, surveillance, and epidemiologic investigation, preventing/controlling the transmission of infectious agents/healthcare-associated infections, employee/occupational health, management and communication, education and research, managing the environment of care, and cleaning, sterilization, disinfection, and asepsis. Aim: Assess infection prevention and control practices in the emergency department in King Khalid Hospital, Hail City, Saudi Arabia. Methods: A quantitative, descriptive correlational study design was used to conduct the study in the emergency department (ED) unit at King Khalid Hospital (KKH), Hail City, Saudi Arabia. All available nurses working in the emergency department KKH at the time of data collection. A self-administered structured questionnaire was utilized to collect data in the current study. Results: 71.7% (n=76) of the participants were between 25 and 35 years old, 24.5% (n=26) were between 36-45 years old, and only 3.8% (n=4) were over 45 years old. 79.2% of the nurses reported that there is a curriculum or program for IC training for doctors and nurses, 71.7% mentioned that they have recommendations for IC training link doctors and nurses, 84.8% reported that IC issues are parts of the examination and evaluation in basic training for nurses, and there are policies and procedures elaborating infection control interventions. Besides, 82.1% of the nurses reported infection control policies and guidelines in their units, and 83% and 82.7% stated that there is a list of reportable infectious agents available in their unit and accessible to all staff, and there is an active infection control team, respectively. Conclusion: Overall, this study indicated that nurses reported a high level of infection prevention and control practices in the ED of King Khalid Hospital. There was no statistically significant association between nurses' knowledge of infection prevention and control practices and their demographic characteristics. Implementing regular training and educational programs for nurses, focusing on updating knowledge and skills in IPC practices, was recommended.

Doctors’ voices generate support for abortion care: Results from a nationally representative survey

ObjectiveWe tested abortion messaging to develop evidence-based communication recommendations for doctors who provide abortion care. Study DesignWe conducted an on-line survey in a nationally representative sample of 1,215 people, using NORC’s Amerispeak® Panel. We surveyed participants before and after viewing two brief videos featuring doctors who provide abortion care speaking about their work. Doctors’ comments were grounded in strategic communications and applied psychology research and emphasized caregiving roles, avoided political-sounding punditry, and acknowledged abortion’s complexities. We assessed participants’ characterizations of doctors who provide abortion care, how these characterizations impact support for abortion restrictions and overall views on abortion legality. We analyzed pre-post data using descriptive statistics, t-tests and multivariable regression. ResultsPost-messaging more participants endorsed positive descriptors of doctors who provide abortion care (p<0.001,t=8.99); fewer endorsed negative descriptors (p<0.001,t=10.32). Increased post-messaging endorsement of positive descriptors predicted declines in support for abortion restrictions (AOR = 1.69,p<0.01); decreased endorsement of negative descriptors did not. After messaging, 37% of respondents said their views of doctors who provide abortion care made them less likely to support abortion restrictions, compared to 14% before (p<0.001,t=-6.9). After messaging there was more overall support for legal, accessible abortion and less for abortion being mostly illegal (46%→48% and 24%→22%,p<0.001;t=-4.11). ConclusionsWhen doctors who provide abortion care use messaging recommendations that include speaking about abortion’s complexities and avoiding political-sounding punditry, they generate more support for legal abortion and less for restrictions. ImplicationsThe voices of doctors who provide abortion care shape abortion public opinion. When doctors speak from caregiving perspectives, avoid punditry, and acknowledge abortion’s complexities they generate more support for legal abortion and less for restrictions. However, audiences may not be aware a priori that ideas of doctors shape their views.

Epidemic and infection control measures in charitable institutions for children in the 19th — early 20th century (based on the materials from Saint-Petersburg)

Based on the documents stored in archives, here we present the analysis of the evolution of forms of the epidemic and infection control measures in charitable institutions for children in Saint-Petersburg with the deve-lopment of medicine, the introduction of sanitary and hygienic standards, and guidelines based on the acquired experience. The causes of mass infection of the pupils have been identified, which were associated with the lack of well-established daily hygienic practices for pupils, their close contact within the institution, and the presence of visiting caregivers in orphanages who had extensive contacts outside. At the state level, until the end of the 19th century, there were no uniform sanitary norms and rules, as well as specialized schemes for their identification and con-trol. As the analysis shows, this resulted in the fact that the trustee boards of orphanages and doctors assigned to them were forced, sometimes with the help of police, to independently introduce restrictive measures at the ad-ministrative level, determine treatment methods and manage all emerging issues aimed at preserving health of the pupils, while often not having sufficient professional knowledge and experience for this. The documents sug-gest that due to the lack of established diagnostic system, the treatment methods practically did not differ for vari-ous infectious diseases, and the recommendations of doctors for a long time mainly consisted of changing the diet, purifying the air, isolating patients, and burning possessions of sick children. Considering religious education in all charitable institutions, lents and fast days were supposed to be observed, which required the approval of the clergy, who, although as a rule did not create serious obstacles, but granted individual and limited permits. In the beginning of the 19th century, smallpox vaccination began, and such practices gradually expanded thanks to the state and benefactors, but due to the lack of support from church, as well as conservatism and superstition of a significant proportion of parents, they did not become widespread and routine.

Interwencja antynikotynowa a e-papierosy i podgrzewacze tytoniu – o czym należy pamiętać? Rekomendacje dla lekarzy praktyków mających bezpośredni kontakt z pacjentem uzależnionym od nikotyny w zakresie interwencji antynikotynowej

Interwencja antynikotynowa a e-papierosy i podgrzewacze tytoniu – o czym należy pamiętać? Rekomendacje dla lekarzy praktyków mających bezpośredni kontakt z pacjentem uzależnionym od nikotyny w zakresie interwencji antynikotynowej

Interpretation of Chinese guideline for the clinical management of patients with ruptured intracranial aneurysms (2024)

Aneurysmal subarachnoid hemorrhage (aSAH) is a life-threatening neurological emergency with high mortality, and even patients receiving optimal medical care may develop long-term disability, which seriously affects their quality of life and increases the heavy medical burden on society and families. To provide comprehensive clinical management advice, the Society of Neurosurgery of the Chinese Medical Association, the Society of the Chinese Stroke Association of the National Medical Center for Neurological Diseases, and the National Clinical Research Center for Neurological Diseases jointly formulate "Chinese Guidelines for the Clinical Management of Patients With Ruptured Intracranial Aneurysms in 2024". The evidence sources are divided into the Chinese population and other populations, using a modular format to provide recommendations, summaries of relevant opinions, and future research directions on epidemiology, clinical imaging diagnosis, prognosis evaluation, treatment strategies and choices, anesthesia management, perioperative care, and recommendations for the management of aSAH in special populations. It provides practical clinical guidance and recommendations for doctors and related professionals.

Investigation of real-life drug intake behaviour in older adults and geriatric patients in Northern Germany – A biopharmaceutical perspective

Dosing conditions (type and amount of accompanying fluid, the type of food, the time of administration, and dosage form modifications such as crushing tablets) are critical and affect the performance of oral dosage forms in the gastrointestinal tract and thus bioavailability. Because older adults are the primary users of medications and are more susceptible to adverse effects, it is important to understand how they take their medications in order to reduce risks and increase benefits of the pharmacotherapy. The aim of the study was to investigate the real-life drug intake behaviour in geriatric patients and older adults and discuss their influence on drug absorption after oral administration. The data from two settings home vs. hospital and genders women vs. men were presented. A questionnaire study was performed among people aged at least 65 years from two settings (hospital vs. home), recruited mostly from community pharmacies and a regional hospital in Mecklenburg – Western Pomerania. The obtained data demonstrates that older adults and geriatric patients take their medications in the same way regardless of the setting and gender. There were no significant differences. Interviewed participants were mostly adherent to the doctor's recommendations and mostly took their medications in the same way every day. Medications are most commonly taken with a small (100 mL) or large (200 mL) glass of noncarbonated water, after food (during or after breakfast 64 % of intakes in the morning and during or after dinner 81 % of intakes in the evening). Meal usually consisted of bread, either with jam or honey (breakfast), or ham and cheese (dinner). All reported dosage form modifications were made to tablets. In almost all cases it was splitting the tablet, which was performed due to doctor's indication.

RELATIONSHIP BETWEEN NEUTROPHILTO HIGH-DENSITY LIPOPROTEIN CHOLESTEROL AND THE SEVERITY OF CORONARY STENOSIS IN PATIENT WITH CORONARY ARTERY DISEASE

Objective: Coronary artery disease (CAD) is a common cardiovascular disease related to atherosclerotic plaque formation. The Neutrophil to HDL-C ratio (NHR) reflects the inflammation process and dyslipidemia, affecting the atherosclerosis pathophysiology. This study aims to evaluate the relationship between NHR and the severity of coronary stenosis in CAD patients. Design and method: A prospective study with in-hospital follow-up in all patients admitted to Cardiology Center - Hue Central Hospital, whose were diagnosed with coronary artery disease between April 2023 and February 2024 were enrolled. The diagnostic criteria of CAD according to the recommendation of the Vietnam National Heart Association 2022. All patients received a comprehensive clinical examination and laboratory tests: complete blood count, high-sensitive Troponin-T, Total Cholesterol, HDL-Cholesterol, 12-leads EKG, transthoracic echocardiogram. All patients were undergone coronary angiography with doctor recommendation or self-requirement. Patients with history of coronary artery interventions, either balloon or stenting, or patient with history of coronary artery bypass graft were excluded from the study. Patients with acute or chronic infection state, end-stage kidney failure, end-stage renal disease, severe heart failure, severe valvular diseases and hematology diseases, patients being used corticosteroid therapy were also excluded. Results: Mean age was 67.12 ± 11.39 years, 58.5% male. The mean NHR increased according to Gensini score subgroups (p &lt; 0,01). Compared to the group with unincreased hs-Troponin (4.38 ± 1.56), the group with increased hs-Troponin showed a significantly higher mean NHR (6.14 ± 3.17) (p &lt; 0.01). There was a moderate correlation between NHR and Gensini score with r = 0.343, p&lt;0.01. NHR demonstrated moderate ability to predict patients with significant narrowing of coronary branches with the AUC= 0.727. With the NHR at 5.324, NHR has 54.2% in sensitivity and 83.3% of specificity in predicting of the significant coronary artery stenosis. Conclusions: Our study demonstrated there was a moderate correlation between Neutrophil to HDL-C ratio (NHR) and Gensini score. Neutrophil to HDL-C ratio (NHR) demonstrated moderate ability to predict patients with significant narrowing of coronary branches.

Multifactorial analysis of willingness to undergo subcutaneous allergen immunotherapy in pediatric patients.

To explore factors influencing the acceptance of allergen immunotherapy (AIT) for the treatment of allergic respiratory diseases by pediatric patients and their families. A total of 406 children (210 males and 196 females) attending the pediatric outpatient clinics and wards of the Renji Hospital, Shanghai Jiao Tong University School of Medicine from June 2020 to April 2022. Those who met the criteria for the AIT treatment, were included in the survey. An online 20-item questionnaire was developed. Data on patient's general characteristics, allergic disease status, family history of allergies, general family information, parental knowledge of allergic diseases, and whether the AIT treatment was recommended by a physician, were collected. The patients were divided into two groups according to their willingness to receive AIT: a reluctant or neutral group (n = 182), and a willing group (n = 224). A univariate analysis of the willingness to undergo AIT was done to detect parameters that significantly differed between the groups, and the identified factors were used as independent variables in the multifactorial logistic regression analysis. The severity of allergic disease, presence of drug allergy, occurrence of severe allergic reactions, mother's education, distance from home to the hospital, parental knowledge of allergic diseases, and whether the doctor recommended AIT were all statistically different between the groups (p < 0.05). Multifactorial logistic regression analysis showed that the degree of allergic rhinitis (AR), or asthma (AS), parental knowledge of allergic diseases, and doctor's recommendation of AIT were the factors that influenced the willingness of pediatric patients to receive AIT. The severity of AR and AS, parental knowledge of allergic diseases, and doctor's recommendation influenced the willingness of pediatric patients to receive AIT.