Event Abstract Back to Event Large zinc finger transcription factor Schnurri-3 functions in the osteochondroprogenitor cell to regulate bone mass ANJU SINGH1*, Dallas Jones2* and Laurie Glimcher3 1 NCATS-NIH, United States 2 Merck Pharmaceuticals, United States 3 Weill Cornell Medical College, United States The large zinc finger transcription factor Schnurri-3 (Shn3) was originally identified as a DNA binding protein of the heptameric recombination signal sequence for V(D)J recombination of immunoglobulin genes. Previous studies from our group have revealed an unexpected role for Shn3 in the skeletal system and have identified Shn3 as a central regulator of postnatal bone mass. Mice lacking Shn3 display severe osteosclerosis primarily due to enhanced osteoblast activity. In this study we have characterized a specific cell population in which Shn3 functions to regulate bone mass. Based on analysis of mice lacking Shn3 in osterix or collagen II expressing cells, we hypothesized that Shn3 must be functioning in the common progenitor cell for osteoblasts and chondrocytes-the osteochondroprogenitor cell. However, characterization of this cell population has been limited due to lack of definitive cell surface markers to phenotype these cells. We established a flow cytometry based high throughput screen to identify a panel of unique cell surface molecules that can be used to identify and isolate osteochondroprogenitor cells. These osteochondroprogenitor cells not only formed bone and cartilage in vitro but also in vivo when transplanted under the kidney capsule of recipient donors. Lastly, we were able to demonstrate that Shn3 functions intrinsically in the osteochondroprogenitor cells to control bone mass. Keywords: osteoprogenitor cell, Schnurri-3, Bone, osteoblast, bone stem cell Conference: 15th International Congress of Immunology (ICI), Milan, Italy, 22 Aug - 27 Aug, 2013. Presentation Type: Abstract Topic: Translational immunology and immune intervention Citation: SINGH A, Jones D and Glimcher L (2013). Large zinc finger transcription factor Schnurri-3 functions in the osteochondroprogenitor cell to regulate bone mass. Front. Immunol. Conference Abstract: 15th International Congress of Immunology (ICI). doi: 10.3389/conf.fimmu.2013.02.00563 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 22 Apr 2013; Published Online: 22 Aug 2013. * Correspondence: Dr. ANJU SINGH, NCATS-NIH, Rockville, United States, ANJU.SINGH@NIH.GOV Dr. Dallas Jones, Merck Pharmaceuticals, Boston, United States, dallas.jones@merck.com Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers ANJU SINGH Dallas Jones Laurie Glimcher Google ANJU SINGH Dallas Jones Laurie Glimcher Google Scholar ANJU SINGH Dallas Jones Laurie Glimcher PubMed ANJU SINGH Dallas Jones Laurie Glimcher Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.