Occlusion or posture change of the face in natural scenes has typical asymmetry; however, an asymmetric face plays a key part in the lack of information available for facial expression recognition. To solve the problem of low accuracy of asymmetric facial expression recognition, this paper proposes a fusion of channel global features and a spatial local information expression recognition network called the “Channel–Spatial Integration Network” (CSINet). First, to extract the underlying detail information and deepen the network, the attention residual module with a redundant information filtering function is designed, and the backbone feature-extraction network is constituted by module stacking. Second, considering the loss of information in the local key area of face occlusion, the channel–spatial fusion structure is constructed, and the channel features and spatial features are combined to enhance the accuracy of occluded facial recognition. Finally, before the full connection layer, more local spatial information is embedded into the global channel information to capture the relationship between different channel–spatial targets, which improves the accuracy of feature expression. Experimental results on the natural scene facial expression data sets RAF-DB and FERPlus show that the recognition accuracies of the modeling approach proposed in this paper are 89.67% and 90.83%, which are 13.24% and 11.52% higher than that of the baseline network ResNet50, respectively. Compared with the latest facial expression recognition methods such as CVT, PACVT, etc., the method in this paper obtains better evaluation results of masked facial expression recognition, which provides certain theoretical and technical references for daily facial emotion analysis and human–computer interaction applications.