Due to its economic and environmental benefits, using reclaimed asphalt pavement (RAP) and reclaimed asphalt shingles (RAS) in new hot-mix asphalt (HMA) has become an integral part of today's asphalt industry. The advantages of using RAP and RAS in HMA are not limited to economic and environmental benefits, and may result in improving a number of mix performance characteristics including rutting and resistance to moisture-induced damage. Despite aforementioned benefits, concerns over premature pavement distresses resulting from using RAP and RAS limit their usage in HMA. Furthermore, because of the lack of mechanistic performance data, use of new mixes containing RAP and RAS remains limited. Therefore, the present study was undertaken to investigate the effects of using different amounts of RAP and RAS on laboratory performance of HMA, and to generate valuable input design parameters for implementation of the mechanistic-empirical pavement design guide (M-EPDG), using local materials. Four types of base course mixes containing 0% RAP, 25% RAP, 40% RAP and 20% RAP+5% RAS, and three types of surface course mixes containing 0% RAP, 25% RAP and 20% RAP+5% RAS were tested. Laboratory tests were conducted to evaluate stiffness, low-temperature cracking, fatigue life, rut and moisture-induced damage potential of the mixes. It was found that dynamic modulus and creep compliance of the asphalt mixes increase and decrease, respectively, with an increase in the amount of RAP and/or RAS used in the mix. Fatigue life was found to increase with increasing RAP content up to 25%, and to decrease when the RAP and/or RAS content exceeded 25%, or when RAS was used in the mix. It should be noted that this conclusion was drawn based on a 15% increment in RAP content. Hamburg wheel tracking (HWT) test results showed increased resistance to rutting and moisture-induced damage, with an increase in the amount of RAP and/or RAS. However, the tensile strength ratio test results were not confirmed by HWT. The findings of this study are expected to be helpful in understanding the effects of using different amounts of RAP and RAS on the performance of asphalt mixes produced using local materials. Furthermore, valuable design input parameters, developed in this study for new mixes containing RAP and RAS, may be used for calibration of the M-EPDG input parameters, with local materials.