Recent Outbreaks Research Articles

Serological and molecular analysis of Leishmania infection in a recent outbreak of visceral leishmaniasis in South Omo Zone, Ethiopia.

Ethiopia has a high burden of visceral leishmaniasis. Recently, there was a significant increase in cases in the South Omo Zone. This study aims to assess the prevalence of Leishmania donovani infection and its associated factors. A household-based cross-sectional study was carried out in January 2023 in the South Omo Zone in Ethiopia. Dried blood spot samples were collected from 382 randomly selected study participants. Direct agglutination test (DAT) and kinetoplast DNA real-time PCR tests were performed to detect L. donovani infection. Participants' sociodemographic, clinical and risk factors for L. donovani infection data were collected using questionnaires. Bivariate and multivariate logistic regressions were used to analyze the data. Febrile cases were checked for malaria with a multiplex PCR assay. Overall prevalence of L. donovani infection among the sampled population was 32.5% (n=124), of which 41.1% (n=51) was detected by PCR, 33.9% (n=42) by DAT and 25.0% (n=31) by both tests. The majority of the positives were from the Logira (28.2%; n=35) and Dilbayne (29.0%; n=36) villages. Participants residing in Logira (adjusted OR [AOR]: 5.80; 95% CI 1.85 to 18.15) and Dilbayne (AOR: 3.38; 95% CI 1.15 to 9.96) villages and owning cows (AOR: 2.31; 95% CI 1.03 to 5.15) showed an association with Leishmania infection. Plasmodium falciparum was detected in 3.4% (n=2) of 59 febrile participants. The prevalence of L. donovani infection in the South Omo Zone is high. Further research on the role of cows in the transmission cycle is needed to design the best strategy to control Leishmania infection in the South Omo Zone. Such interventions should focus on the Logira and Dilbayne villages, where most of the infections were identified.

Dielectric Heating Protocol of Three Low Moisture Flours as Affected by Moisture, Temperature and Mass at 2.45 and 5.8 GHz

ABSTRACT Present studies investigate the dielectric properties (dielectric constant and dielectric loss factor) of three low moisture flours (barley, chickpea and wheat) in the moisture content range 2%–10% (w. b.) and temperatures 10°C–60°C at 2.45 and 5.8 GHz. Measurements were taken using cavity perturbation method in conjunctions with Vector Network Analyzer. Results show that dielectric constant and loss factor increased with temperature as well as moisture content both at 2.45 and 5.8 GHz but decreased with increase in frequency. Change in mass of all flours during heating does not affect dielectric properties at both frequencies. A second order regression equation is generated to predict dielectric properties at both frequencies for entire temperature and moisture. Penetration depths of all flours decreased with increase in moisture content and temperature at 2.45 and 5.8 GHz. These studies provide valuable insights to heating protocol of flours in view of recent flours-related disease outbreaks.

Management of critically ill children with acute necrotizing encephalitis during an H1N1 outbreak in a tertiary pediatric hospital: a series of three cases and literature review.

Acute necrotizing encephalopathy (ANE) is a severe neurologic condition that is diagnosed clinically and upon specific radiologic imaging. Medical treatment of this condition is uncertain, and timing is likely very important to minimize brain damage and systemic inflammation. The present case series describes three patients suffering from ANE secondary to influenza A/H1N1 infection during a recent outbreak, treated with increasingly aggressive anti-inflammatory approach, and with significantly different outcomes.

Mpox and Lessons Learned in the Light of the Recent Outbreak: A Narrative Review.

According to the WHO, more than 90,000 cases of mpox have been reported since the 2022 worldwide outbreak, which resulted in 167 deaths, while a new outbreak in Africa since 2023 has resulted in over 18,000 cases and 617 deaths. Mpox is a zoonosis caused by the monkeypox virus, a double-stranded DNA virus belonging to the Orthopoxvirus genus, which causes smallpox-like illness. Until 2022, cases were predominately located in West and Central Africa, with only sporadic cases and outbreaks reported in other parts of the world. During the 2022 outbreak, the primary mode of transmission was sexual contact among men who have sex with men. The changing epidemiology of mpox resulted in new disease phenotypes and populations at risk, disproportionally affecting people who live with HIV. Commonly presenting as a mild, self-limiting illness, mpox can cause severe and protracted disease in people with HIV with a CD4 count < 200 cell/mm3. The global emergence of mpox that followed and intersected with COVID-19 mobilized the scientific community and healthcare stakeholders to provide accurate diagnostics, preventive vaccines and treatment to those most affected. Despite existing gaps, this rapid response helped to contain the outbreak, but challenges remain as new variants emerge. Preparedness and readiness to respond to the next outbreak is crucial in order to minimize the impact to the most vulnerable.

Blood-Feeding Patterns and Resting Behavior of Aedes aegypti from Three Health Districts of Ouagadougou City, Burkina Faso.

Recent dengue outbreaks have occurred in Ouagadougou and Bobo-Dioulasso, the two major cities of Burkina Faso. Dengue is a viral disease transmitted primarily by Aedes aegypti, a highly anthropophilic mosquito that thrives in human-transformed environments and breeds predominantly in artificial containers. In 2018, we investigated the resting and blood-feeding habits of Ae. aegypti in urban settings of Ouagadougou. In a 3-month cross-sectional study starting in August 2018, indoors and outdoors resting adult mosquitoes were collected using Prokopack aspirators in three health districts (HD). All mosquitoes were morphologically identified, and DNA was extracted from blood-fed Ae. aegypti females. A multiplex polymerase chain reaction with specific primers was used to identify the origin of the blood meal. A total of 4,256 adult Ae. aegypti mosquitoes, including 1,908 females, were collected. A preference for exophily was recorded in Bogodogo and Nongremassom, although an unexpectedly higher proportion of blood-fed females were found indoors than outdoors. Respectively, 96.09%, 91.03%, and 95.54% of the blood meals successfully analyzed in Baskuy, Bogodogo, and Nongremassom were from a single human host, with the remainder from domestic mammals as single or multiple hosts. Modeling total Ae. aegypti and blood-fed female counts showed that among other predictors, human density, outdoor environment, and house type affect their total densities. Our study revealed an exophilic tendency as well as a pronounced anthropophilic preference of Ae. aegypti adults, critical findings to consider when planning accurate entomological surveillance and effective interventions against Ae. aegypti in urban settings.

Stability and Optimality Criteria for an SVIR Epidemic Model with Numerical Simulation

The mathematical modeling of infectious diseases plays a vital role in understanding and predicting disease transmission, as underscored by recent global outbreaks; to delve deep into the dynamic of infectious disease considering latent period presciently is inevitable as it bridges the gap between realistic nature and mathematical modeling. This study extended the classical Susceptible–Infected–Recovered (SIR) model by incorporating vaccination strategies during incubation. We introduced multiple time delays to an account incubation period to capture realistic disease dynamics better. The model is formulated as a system of delay differential equations that describe the transmission dynamics of diseases such as polio or COVID-19, or diseases for which vaccination exists. Critical aspects of the study include proving the positivity of the model’s solutions, calculating the basic reproduction number (R0) using next-generation matrix theory, and identifying disease-free and endemic equilibrium points. The local stability of these equilibria is then analyzed using the Routh–Hurwitz criterion. Due to the complexity introduced by the delay components, we examine the stability by studying the roots of a fourth-degree exponential polynomial. The effects of educational campaigns and vaccination efficacy are also investigated as control measures. Furthermore, an optimization problem is formulated, based on Pontryagin’s maximum principle, to minimize the number of infections and associated intervention costs. Numerical simulations of the delay differential equations are conducted, and a modified Runge–Kutta method with delays is used to solve the optimal control problem. Finally, we present a few simulation results to illustrate the analytical findings.

A Recent Advance in the Diagnosis, Treatment, and Vaccine Development for Human Schistosomiasis.

Schistosomiasis, which affects a large number of people worldwide, is among the most overlooked parasitic diseases. The disease is mainly prevalent in sub-Saharan Africa, southeast Asian countries, and South America due to the lack of adequate sanitation. The disease is mainly associated with poor hygiene, sanitation, and contaminated water, so it is also known as a disease of poverty. Three Schistosoma species (S. mansoni, S. japonicum, and S. haematobium) cause significant human infections. Co-infections with Schistosoma and other parasites are widely common. All these parasites may cause intestinal or urogenital schistosomiasis, where the disease may be categorized into the acute, sensitized, and chronic phases. The disease is more prevalent among school children, which may cause anemia and reduce development. Chronic infections frequently cause significant liver, intestinal, and bladder damage. Women exposed to contaminated water while performing normal duties like washing clothes might acquire urogenital schistosomiasis (UGS), which can cause tissue damage and raise the risk of blood-borne disease transmission, including human immunodeficiency virus (HIV) transmission. Praziquantel (PZQ) is the World Health Organization (WHO)-prescribed treatment for individuals who are known to be infected, but it does not prevent further re-infections with larval worms. Vaccine development and new molecular-based diagnosis techniques have promised to be a reliable approach to the diagnosis and prevention of schistosomiasis. The current review emphasizes the recent advancement in the diagnosis of schistosomiasis by molecular techniques and the treatment of schistosomiasis by combined and alternative regimes of drugs. Moreover, this review has also focused on the recent outbreak of schistosomiasis, the development of vaccines, and their clinical trials.

A Red Alert for Eye Conjunctivitis in Pakistan: A Call for Action and Awareness

For the recent upsurge in the cases of conjunctivitis particularly in Punjab, Pakistan has reached an alarming level. Till September 2023, almost 395,929 cases have been reported only in Punjab because of such an endemic condition schools have been temporarily closed. About 17000 cases were reported alone in Bahawalpur nearly doubling the figures from the previous month but currently, the epicenter of the break is Lahore as the recent outbreaks have also been seen worldwide like Malaysia, Taiwan, Japan, Brazil, and India. The primary cause of the epidemic is coxsackievirusA24 confirmed through genomic analysis. Coxsackievirus A24 is a non-enveloped, positive-stranded RNA virus which produces a polyprotein that forms a structural and non-structural component. This is responsible for acute hemorrhage conjunctivitis which is a viral disease and can spread rapidly as the virus belongs to a highly contagious genotype 4. Its symptoms are redness, pain, irritation discharge from the eye, and light sensitivity with an incubation period of 24 to 48 hours. Transmission can occur through hand-to-eye and eye-to-hand contact of the infected person as well as through contaminated surfaces. As the virus has the belated to evolved rapidly preventive measures are a necessity which include prevention from touching the eyes, practicing regular hand washing, cleaning contact lenses frequently, avoiding the sharing of personal items and using protective eyewear.

Therapeutic agents for the treatment of human mpox.

The aim of this study was to summarize the current knowledge of therapeutic options for mpox (formerly known as monkeypox) in the context of recent outbreaks and the ongoing evolution of the virus. Multiple therapeutic agents, including tecovirimat, cidofovir, brincidofovir, and vaccinia immune globulin, have been used during the multicountry outbreak of mpox caused by Clade 2b monkeypox virus that began in 2022. Tecovirimat has been most extensively used, based on efficacy against mpox lethal challenge in animal models, and human safety data. Real-world observational evidence has further supported safety with minimal adverse events in large cohorts and mixed reports of reductions in time to lesion resolution. Several prospective randomized controlled trials using tecovirimat are underway with headline results from a study in the Democratic Republic of the Congo showing no difference in lesion resolution compared to placebo. Other studies including in outpatient settings are underway in Europe and the Americas. Cidofovir and brincidofovir, limited by adverse event profiles, have been less extensively studied. Vaccinia immune globulin has been used predominantly in salvage therapy for severe mpox, with no large observational series available. The 2022 multicountry outbreak of mpox marked a public health emergency. Agents approved for smallpox management were widely used for mpox, supported by animal and in-vitro evidence, and human safety data. The large number of human cases has allowed retrospective observational study of these agents and facilitated recruitment in prospective trials. The ongoing evolution of the virus may pose challenges for therapeutic interventions, necessitating rigorous randomized controlled trials to guide clinical use.

Molecular detection of lumpy skin disease virus in naturally infected cattle and buffaloes: unveiling the role of tick vectors in disease spread.

Lumpy skin disease (LSD) is a viral disease that affects cattle and buffaloes in Egypt, causing considerable economic losses in the animal sector. This study aimed to investigate the recent outbreak of LSDV in cattle and buffaloes and evaluate the potential role of the hard tick Rhipicephalus annulatus in their transmission through isolation and molecular characterization by multiplex PCR (mPCR) and real-time quantitative PCR (rt-qPCR) assays. A total of 50 skin biopsies (cattle n = 30, buffaloes n = 20), 110 nasal swabs (cattle n = 76, buffaloes n = 44), and 129 blood samples (cattle n = 84, buffaloes n = 45) were collected. In addition, 145 hard ticks of different stages were collected from cattle and buffaloes of different breeds and ages in different governorates in Egypt from November 2021 to June 2022. Multiplex PCR and real-time quantitative PCR (rt-qPCR) assays based on SYBR Green and targets (P32, VP32, G protein, and viral fusion protein) were used. We identified positive results in 17 out of 30 cattle skin biopsies (56.6%), 1 out of 7 buffalo skin scabs (14.3%), and 5 out of 45 buffalo blood samples (11.11%) using mPCR and RT-qPCR methods. We successfully isolated LSDV from hard ticks and cattle infested with ticks and exhibited characteristic signs of LSD on the chorioallantois membrane (CAM) of specific pathogen-free embryonated chicken eggs (SPF-ECE). The isolates were confirmed by multiplex PCR and RT-qPCR. The cyclic threshold (Ct) with correlation-slandered curve values of rt-qPCR ranging from 10.2 to 36.5 showed the amount of LSDV-DNA in different samples. The study's findings demonstrated the widespread circulation of LSDV in both cattle and buffaloes in Egypt and provided strong evidence that hard ticks R. annulatus play a role in the transmission of LSDV in susceptible animals.

Rapid drops of ocean temperatures in several shallow bays in Nova Scotia during a recent cold air outbreak

Abstract From February 3-5, 2023 Atlantic Canada experienced an extremecold Arctic air outbreak with high winds that set many local meteor-ological records, including wind chills as low as -47°C. The impacts of the cold air outbreak on ocean temperatures and ice formation are investigated using predictions from the Coastal Ice-Ocean Prediction System for the East Coast of Canada (CIOPS-E), developed by Environment and Climate Change Canada. Observations from moorings further inform the predictions. The analysis suggests that during the event, several shallow bays and coastal areas in Nova Scotia experienced significant, abrupt temperature decreases ranging from 1.0 to 3.9°C. Overall cooling estimated by the model was 2.3°C for nearshore locations where observations recorded an average temperature decrease of 3.0°C. On the other hand, at individual sites the difference between observed and modelled cooling was up to 2.4°C. This difference can be attributed partly to the fact that the model does not adequately resolve the coastline features of some of the nearshore mooring sites. In comparison, we also analyze another cold air outbreak that occurred on December 15-18, 2016, with wind chills as low as -37°C. The ocean temperatures changes associated with this earlier event saw decreases of 0.8 to 3.5°C, potentially contributing to an ongoing fish kill in St. Mary’s Bay (near the mouth of the Bay of Fundy) at the time. Keywords: Ocean temperature, Cold air outbreak, Ocean forecasting, Shallow bays, Nova Scotia

Commercial bacteriophage preparations for the control of Listeria monocytogenes and Shiga toxin-producing Escherichia coli in raw and pasteurized milk

Listeria monocytogenes was the etiologic agent in nearly all recent outbreaks in North America attributed to pasteurized dairy products, whereas Escherichia coli O157 infections were responsible for most of the rare, yet serious complications from outbreaks involving unpasteurized dairy. This study determined the susceptibility of selected strains of L. monocytogenes and Shiga toxin-producing E. coli (STEC) to commercial phage preparations and their ability to control these pathogens in pasteurized and raw milk during 7-day storage at 7 °C. Both phage products demonstrated high lytic efficiency against 17 strains of L. monocytogenes whereas the efficiency of E. coli phages was more variable against 11 strains of O157 and non-O157 STEC. Broth microdilution assays identified effective endpoint multiplicities of infection (MOI) ranging from log 2.53 to 5.13, which differed between strains of L. monocytogenes and phage products. Mean log MOIs of E. coli phages against STEC also varied within and between products from 0.43 to 7.05. Despite these observations, the change in counts over time of three L. monocytogenes strains exposed to phage in pasteurized milk (log MOI 6) was similar with counts ∼ 4 log CFU/mL lower than control at day 7. Results for STEC O157 varied by strain but counts were lower than control in all cases by 72 h thorough day 7. Titers on isolates of both pathogens isolated from pasteurized milk indicated that the surviving populations were less susceptible to phage. The addition of a phage preparation to raw milk did not reduce populations of either pathogen or affect the change in counts of any strain over time when compared to control. Reduced efficacy in raw milk may be attributed to reduced phage binding as titers in raw milk decreased steadily (∼2 log PFU/mL) during storage. Commercial phage products may be a promising pathogen control intervention for pasteurized dairy products, warranting further investigation.

New Insights into the Epidemiological Characteristics of Mycoplasma pneumoniae Infection before and after the COVID-19 Pandemic.

Mycoplasma pneumoniae (M. pneumoniae), a prevalent respiratory pathogen affecting children and adolescents, is known to trigger periodic global epidemics. The most recent significant outbreak commenced in the first half of 2023 and reached its peak globally during the autumn and winter months. Considering the worldwide repercussions of the COVID-19 pandemic, it has become increasingly essential to delve into the epidemiological characteristics of M. pneumoniae both before and after the pandemic. This review aims to provide a comprehensive analysis of the key features of M. pneumoniae epidemics in the pre-and post-COVID-19 contexts, including but not limited to shifts in the susceptible population, the molecular genotypes of the pathogen, the clinical manifestations, and potential new trends in drug resistance. Additionally, we will introduce the latest advancements in the diagnosis of M. pneumoniae.

A-205 Evaluating the Cost and Importance of Supply Chain Resilience in the Clinical Laboratory

Abstract Background Recent pandemics, epidemics and outbreaks continually underscore the critical importance of resilient supply chains in healthcare, particularly in clinical laboratories where timely access to supplies is essential for patient care. Supply chain disruptions, whether due to global crises or localized challenges, can significantly impact laboratory operations, leading to delayed diagnoses, compromised patient outcomes, and increased costs. It is estimated that 70%-80% of a patients’ EMR is clinical laboratory results. Despite this, supply chain resilience in clinical laboratories remains an under-addressed issue and remains a buzzword. Methods To evaluate the cost and importance of supply chain resilience in the clinical laboratory, we conducted a comprehensive review and interviews with 9 Healthcare Supply Chain experts analyzing the impact of supply chain disruptions on laboratory operations and patient care. Data was also collected from a diverse range of clinical laboratories, including hospitals, independent labs, and research institutions, spanning different geographic regions as well as a survey of 50 Laboratory experts with a 50% response rate. Key metrics assessed included: -Frequency and duration of supply chain disruptions. -Financial costs incurred due to disruptions, including expenses related to expedited shipping, alternative sourcing, and inventory management. -Impact on laboratory workflow, turnaround times, and patient care outcomes. -Strategies employed to mitigate supply chain risks and enhance resilience. Results Our review revealed findings regarding the cost and importance of supply chain resilience in the clinical laboratory: -Supply chain disruptions were frequent, with 85% of laboratories experiencing at least one significant disruption in the past year and 100% in experienced disruptions 2022. -The average duration of disruptions was 2-3 weeks, leading to substantial delays in test processing and patient care. -Financial costs associated with disruptions averaged $50,000 per laboratory per annum, including expenses for rush orders, and premium-priced alternatives. -Common strategies employed were increased inventory or safety stocks, multi-vendor sourcing, and supply chain mapping. Conclusions The findings of this study underscore the critical importance of supply chain resilience in the clinical laboratory. Supply chain disruptions are not just inconveniences; they pose significant risks to patient safety, operational efficiency, and financial sustainability. Investing in supply chain resilience is imperative for laboratories to fulfill their mission of delivering timely and accurate patient results. To continue to enhance supply chain resilience, laboratories must adopt a proactive approach, leveraging data-driven insights and collaborative partnerships. This includes diversifying supplier networks and fostering closer collaboration between laboratory and procurement teams.

Factors Affecting the Adhesion of Flour Particles to Stainless-steel Surfaces and Vacuum Dry-cleaning

Recent outbreaks and recalls linked to flour-based products have highlighted the need for improved cleaning methods in low-moisture environments. The factors affecting adhesion forces of flour particles, and the vacuum cleaning methodologies to overcome these forces, need to be better understood. The objectives of this study were to: (1) Measure electrostatic charge build-up in flour under different environmental conditions (20, 40, 60% relative humidity at room temperature), (2) quantify how powder size (US standard No. 60–80 or 80–100 mesh), electrostatic charge (charged and uncharged), and relative humidity impact the force required to remove the powder from an electropolished 304 stainless steel coupon (8 × 8 × 0.2 cm), and (3) determine the most effective vacuum nozzle angle (0, 45, 90° relative to the surface) for cleaning. Chargeability (nC) of flour samples was assessed using Faraday cup electrometry, while the surface adhesion force of the flour particles was measured using a custom-built impact tester. The surface cleanliness after vacuum treatments was assessed using ATP (adenosine triphosphate) swabs and a luminometer. Charged flour samples at 20% relative humidity (RH) exhibited a significantly higher charge compared to those at 40 and 60% RH. Within the 60–80 mesh range, charged flour showed higher adhesion rates than uncharged samples at both 20 and 40% RH. However, in the 80–100 mesh range, charged flour did not show a significant difference in adhesion when compared to uncharged samples at any RH level. Additionally, at 60% RH, surface residues measured by ATP were significantly lower for a vacuum angle of 90° than for 0° across both 60–80 mesh and 80–100 mesh size ranges of wheat flour. The vacuum cleaning treatment proved capable of overcoming the increase in adhesion from triboelectric forces; however, trace flour residues were still detected on stainless steel surfaces postvacuuming, indicating that vacuuming alone may be insufficient.

Smart β-cyclodextrin-dominated helical supramolecular dendritic assemblies improve the foliar affinity and biofilm disruption for treating alarming bacterial diseases

Recent outbreaks of alarming bacterial diseases have significantly impacted global agricultural productivity. Conventional bactericides exhibit certain limitations in efficiently impeding biofilm formation and annihilating biofilm-dispersed pathogens, and often expose to high off-target movement during foliar spraying. Here, we produce an innovative helical dendrimer-like supramolecular material (PhA28@β-CD) assembled by a bioactive small-molecule 2-chlorophenylisopropanolamine (PhA28) and β-cyclodextrin (β-CD) through host-guest recognition principle. In this system, the advisable optimization by a macrocyclic oligosaccharide—β-CD significantly enhances the water-solubility, biocompatibility, and bioavailability of PhA28. At a low-dose of 6.8 μg/mL, PhA28@β-CD discloses an outstanding biofilm disruption rate of 82.4 %, notably exceeding that of PhA28 (60.6 %), which thereby reduces the biofilm-associated virulence. Meanwhile, the self-assembled PhA28@β-CD possesses superior wetting and dispersing properties on hydrophobic leaves, leading to effective foliar deposition and prolong retention of active components. In vivo studies reveal that PhA28@β-CD exhibits superior curative (66.0 %) and protective (72.6 %) activities against citrus canker at 200 μg/mL, markedly surpassing those of the existing bactericide thiodiazole‑copper (46.8 % and 52.2 %) and single PhA28. This material also has broad-spectrum control efficiency (53.0 % ~ 59.5 %) against rice bacterial blight. This research lays the groundwork for developing carbohydrate-optimized multifunctional dendrimer-like assemblies aimed at disrupting biofilms and improving sustained bioavailability to combat bacterial diseases.

Understanding the Recent Mpox Outbreak: Are we Prepared?

Not Mandatory

Dengue outbreaks in northern Nigeria: Evaluating the recommended Takeda vaccine and future prevention strategies.

Dengue fever, caused by the dengue virus (DENV), poses a significant public health challenge globally, with Nigeria experiencing sporadic outbreaks. A clear understanding of the dengue burden has not been achieved in Nigeria, just as in other African countries. Understanding the epidemiology and burden of dengue fever is essential for effective prevention and control strategies. This paper examines the recent dengue outbreaks in northern Nigeria, particularly in Sokoto state, and evaluates the recommended Takeda dengue vaccine (TDV) along with future prevention strategies. Despite limited surveillance and underreporting, dengue fever is endemic in Nigeria (with over 5 million cases and 5000 dengue-related deaths in 2023), with recent outbreaks indicating a growing concern. The TDV, a live attenuated tetravalent vaccine, has shown promise in preventing dengue fever, but challenges such as vaccine acceptance and accessibility need to be addressed. Global urbanization contributes to the disease's spread, which is influenced by factors such as population density, cultural beliefs, water storage practices, hygiene, and water supply accessibility. Future prevention strategies must focus on government intervention, community practices, and innovative vector control measures to mitigate the spread of DENV in Nigeria. This study will serve as a valuable reference for policymakers, researchers, and clinicians in the management and control of DENV in Nigeria and Africa as a whole.

COVID 19: Political, Security and Religious Impacts on Nigerian Children

It is unfortunate that corruption and insecurity have affected all spheres of human endeavours in Nigeria. The recent outbreak of Covid-19 otherwise known as coronavirus has created a vacuum regarding its effects on the lives of the citizens in general and children in particular. The prime focus of this paper is to explore the political, security and religious impacts of Covid-19 specifically on the children. This paper analyzes the aforementioned factors of Covid-19 in connection with children as to address injustice against children in the country. This is necessary because children used to be given less attention in political decisions and many of them have been affected as a result of insecurity in different parts of the country. Hence, addressing various factors relating to Covid-19 explored in this paper may be instrumental in helping the children as minors as many international agencies have been trying to solve it. It is therefore suggested that various issues are addressed so that safety can be provided to the children by alienating the multifarious impacts of Covid-19 in the country.

COVID 19: Political, Security and Religious Impacts on Nigerian Children

It is unfortunate that corruption and insecurity have affected all spheres of human endeavours in Nigeria. The recent outbreak of Covid-19 otherwise known as coronavirus has created a vacuum regarding its effects on the lives of the citizens in general and children in particular. The prime focus of this paper is to explore the political, security and religious impacts of Covid-19 specifically on the children. This paper analyzes the aforementioned factors of Covid-19 in connection with children as to address injustice against children in the country. This is necessary because children used to be given less attention in political decisions and many of them have been affected as a result of insecurity in different parts of the country. Hence, addressing various factors relating to Covid-19 explored in this paper may be instrumental in helping the children as minors as many international agencies have been trying to solve it. It is therefore suggested that various issues are addressed so that safety can be provided to the children by alienating the multifarious impacts of Covid-19 in the country.