Recent Advances In Surgery Research Articles

Characteristics and Outcomes of Patients With Unresected Early-Stage Non-Small Cell Lung Cancer

This study describes the characteristics, management, and outcomes of patients with unresected early-stage non-small cell lung cancer (NSCLC). A retrospective review was conducted to identify all patients with unresected stage I or stage II NSCLC diagnosed between 1990 and 1998. Ninety-seven patients were identified who met our criteria. The median age at diagnosis was 68 years; 78% of patients were white, 81% were male, 81% had stage I disease, and 67% had squamous cell carcinoma. Cancer-specific treatment, including chemotherapy, radiation therapy, and combined chemotherapy and radiation therapy, was administered to only 27 patients. The median survival time was 22 months for the treated group and 11 months for the untreated group. The majority of patients with unresected early-stage NSCLC do not receive cancer therapy. They should be thoroughly considered for treatment, however, especially in light of recent advances in surgery and radiation therapy, and the development of more active, less toxic chemotherapeutic agents.

Pediatric renal transplantation: anesthesia and perioperative complications.

The appropriate choice of anesthesia for patients (pts) undergoing renal transplantation (Ktx) requires minimal toxicity and accurate monitoring for pts at high risk for metabolic, cardiovascular, and respiratory perioperative complications. We evaluated the anesthetic management and postoperative follow-up in pediatric Ktx performed in the last 12 years in our institution. From 1988 to 1999, 75 ASA class II-III pts (45 males, 22 females) younger than 18 years scheduled for Ktx were studied: 49 received a graft from a cadaveric donor (CD) and 26 from a living donor (LD). All pts were treated with dialysis within 24 h before the procedure. Standard monitoring consisted of an electrocardiogram, central venous pressure, non-invasive arterial pressure, pulse oximetry, and inspiratory and expiratory gas analysis. If necessary, an arterial cannula and pediatric pulmonary catheter were introduced. Anesthesia was induced with sodium thiopental, propofol, halothane, or sevoflurane and maintained with isoflurane and/or fentanyl and droperidol in O2:N2O (FiO2 0.4%). As muscle relaxants atracurium or cisatracurium besilate were used, except in allergic pts, in whom vecuronium or rocuronium bromide was administered. Dopamine, 20% mannitol, and furosemide were used to increase diuresis. Continuous morphine and ketoralac infusions were used for postoperative pain relief. The surgical technique was the same in all cases. Complications and renal-function (RF) recovery were evaluated relating to CD and LD using the chi-square test; differences in mean anesthesia and surgical time were evaluated by Student's t-test; survival curves were calculated from the day of Ktx to death or last follow-up and estimated by the Kaplan-Meier method. Values of P below 0.05 were considered significant. Postoperative immunosuppressive therapy was based on cyclosporine together with other conventional drugs. Mean anesthesia time was 228 +/- 65 min. Mean kidney ischemia time for CD was 16.5 +/- 4 h. Four pts (3 CD, 1 LD) died within 72 h postoperatively: 3 due to cardiac failure and 1 to metabolic coma. Six pts showed cardiovascular and 3 had infective complications, all successfully treated. Three pts (2 CD, 1 LD) died within 2 to 12 months after, surgery; 10 (6 CD, 4 LD) had graft failure and are still alive on dialysis; 58 (38 CD, 20 LD) are alive in good health after a mean follow-up of 57.6 +/- 36.6 months (range 12-120 months). Fifteen of 26 pts younger than 12 years (21 CD and 5 LD) recovered RF intraoperatively (10 CD, 5 LD); 1 with CD and 1 with LD showed postoperative graft failure and 2 with CD died within 72 h postoperatively, 22 (18 CD and 4 LD) are alive in good health. This group showed no statistical difference compared to pts older than 12 years. Of 16 pts (15 CD and 1 LD) with body weight (BW) less than 25 kg, 6 showed intraoperative (5 CD, 1 LD) recovery of RF. The 3 deaths were all in CD pts, 2 within 72 h and one 2 months after surgery; only 1 LD had postoperative graft failure. Twelve pts (75%) (12 CD, 80%) are alive in good health. Compared to pts with BW of 25 kg or more, this group showed lower intraoperative recovery of RF (P < or = 0.05). No peri- and postoperative complications occurred in all 26 LD pts (100%). Recent advances in surgery, anesthesia, immunosuppression, and antimicrobial prophylaxis have made Ktx a more predictable procedure even in pediatric pts. For high-risk pts, mortality and morbidity can be controlled by accurate surgical, anesthetic, and postoperative management. Pts younger than 12 years and with BW less than 25 kg are more likely to develop peri- and postoperative complications.

Preservation of rectal function after low anterior resection with formation of a neorectum

Recent advances in surgery have enabled low rectal cancers to be resected, while at the same time restoring bowel continuity and preserving the anal sphincter. Although a permanent stoma is avoided and the operation is oncologically sound, function may be compromised. Many patients with a straight coloanal anstomosis suffer from urgency, incontinence, and bowel frequency-the so-called anterior resection syndrome. Over the last 15 years, surgical developments have aimed at improving function after restoration of bowel continuity, essentially by creating a neorectum. The best known and most widely practiced operation involves formation of a colonic J-pouch. The physiological and functional outcomes of the colonic J-pouch are discussed, along with controversies surrounding construction. Although a J-pouch improves some aspects of function, the results are not perfect. Alternatives to the colonic J-pouch are appraised, indicating future areas of development.

Recent advances in surgery for colorectal cancer

Recent advances in surgery for colorectal cancer

Cataract

Remarkable advances in the treatment of cataract have been made in recent years. Can we teach the eye well enough for these to be understood and appreciated by our students? After receiving treatment for cataract by intraocular lens implant, the author found out as much as possible about this remarkable operation. Before describing the most recent developments and latest technology, the nature of cataract is discussed together with a brief outline of older methods of treatment. The question is addressed as to whether high-school biology can or should provide sufficient knowledge for pupils to understand this relatively simple defect and appreciate the latest complex remedies. Consideration is given to the possible development of new teaching aids from surgical research materials, for example, introducing pupils to the eye through recent advances in surgery, and so starting them off with the latest applications instead of the conventional ‘naming of parts’.

Recent Advances in Surgery 5

Recent Advances in Surgery 5

BOOK REVIEWS

Australian and New Zealand Journal of SurgeryVolume 66, Issue 3 p. 197-198 BOOK REVIEWS First published: March 1996 https://doi.org/10.1111/j.1445-2197.1996.tb01160.xAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinked InRedditWechat Abstract Book reviewed in this article: Clinical Examination of the Patient. By J. S. P. Lumley and P-M. G. Bouloux Surgical Emergencies in Children: A Practical Guide. Edited by P. A. M. Raine and A. A. F. Azmy Animated Dissection of Anatomy for Medicine (ADAM). Anatomy: Regional, Functional and Applied. By M. Lee and R. Smith Recent Advances in Surgery. Edited by I. Taylor and C. D. Johnson Neurosurgery an Introductory Text. Edited by P. M. Black and E. Rossitch Jr. Volume66, Issue3March 1996Pages 197-198 RelatedInformation

Outcome of aggressive removal of cavernous sinus meningiomas.

Despite recent advances in surgery of the cavernous sinus, meningiomas in that area offer a formidable challenge. The rationale for aggressive surgical removal of cavernous sinus meningiomas is based on the presumption that the extent of removal is inversely related to the rate of recurrence. Over the past 10 years, 41 patients with histologically benign meningiomas involving the cavernous sinus underwent aggressive surgery. Total removal, as confirmed by intraoperative inspection and postoperative radiological studies, was achieved in 31 patients (76%). Twelve patients have been followed for more than 5 years; 10 underwent total tumor removal and only one of these experienced recurrence (5 years after surgery). The other two patients underwent subtotal removal and had symptomatic and radiological evidence of regrowth 3 and 4 years after surgery. Pre-existing cranial nerve deficits improved in only 14% of the patients, remained unchanged in 80%, and worsened permanently in 6%. Seven patients experienced a total of 10 new cranial nerve deficits, four of which involved the nerves subserving ocular motor function. Extraocular muscle function did not worsen in the 25 patients with a seeing eye ipsilateral to the tumor, and no instance of visual worsening occurred. Two patients died 4 months after surgery, one from severe delayed vasospasm and hypothalamic infarction and the other because of a myocardial infarction. Another patient died from a pulmonary embolus on the 9th postoperative day. There were three instances of cerebral ischemia; one was transient, lasting less than 24 hours, while two were related to injury of the middle cerebral artery and resulted in residual hemiplegia. Other complications included three cases of nonfatal pulmonary emboli, two cerebrospinal fluid leaks, and one instance each of exposure keratitis, acute hypothyroidism, and cerebral edema.

CURRENT STATUS OF RENAL TRANSPLANTATION: Patient Selection, Results, and Immunosuppression

Renal transplantation is now well accepted as the preferred mode of renal replacement therapy for patients with end-stage renal disease. Recent advances in surgery, anesthesia, immunosuppression, and antimicrobial prophylaxis have made transplantation a more predictable clinical activity. The demand for kidneys has far outstripped the available supply in the United States, and careful selection and preparation of recipients is required to maximize the effective use of this limited resource. Newer immunosuppressive agents are on the horizon that offer promise for a further reduction in allograft rejection and decrease in post-transplant complications.

Recent Advances in Surgery

Recent Advances in Surgery

Recent Advances in Surgery of the Temporal Bone and Skull Base

Remarkable advances have been made in the field of neuro-otologic and skull base surgery within the past decade. Each component of the "disease model"--prevention, diagnosis, therapy, and rehabilitation--is undergoing rapid progress. The purpose of this paper is to highlight only a few of these achievements. Each topic chosen has witnessed recent advancement in one aspect of the disease model. Neurofibromatosis (prevention) has been subjected to chromosomal mapping, allowing for genetic counseling. Intraoperative facial nerve monitoring (diagnosis) has allowed improved anatomic and functional preservation of this nerve during surgery. Embolization of glomus tumors (therapy) has rendered these difficult lesions more surgically manageable, and cochlear implantation (rehabilitation) has allowed the profoundly deaf to play a more active role in society. Each of these topics is briefly discussed as it relates to the temporal bone surgeon.

Recent advances in surgery for colon and rectal cancer

Surgery is the mainstay of therapy for colon and rectal cancer. Over the past several decades, there have been important advances both in the understanding of the biology of colon and rectal cancer and in the preoperative and operative techniques for treating this disease. Although it appears in some studies that we have made a difference in the survival rates in the treatment of colon and rectal cancer, in actual fact, this phenomenon may only be secondary to better staging and, therefore, a greater ability to prognosticate a particular patient's chance of cure. What has been learned in the past 20 to 30 years is that most colon and rectal carcinomas start as polyps of the colon and rectum. Most often , polyps are sporadic, but there are certain high-risk groups that produce polyps and, consequently, colon and rectal cancer at a much higher rate. The goal of a practicing physician is to identify these high-risk individuals and to recommend frequent screenings so as to intervene before a polyp has had a chance to become a deeply invasive cancer. These high-risk groups are best typified by familial adenomatous polyposis, which if left untreated will, in 100% of cases, lead to the death of a patient from colon or rectal cancer. Other diseases that lead to an increase in colon and rectal cancer but may not go through the usual adenoma-to-carcinoma sequence include inflammatory bowel disease such as Crohn's colitis and ulcerative colitis. Most patients with colorectal carcinoma are asymptomatic at the time of diagnosis. This phenomenon has led to efforts to screen the general population for polyps and for cancer. Screening techniques such as the detection of occult blood in the stool and endogeneous

Recent Advances in Surgery

Recent Advances in Surgery

Recent Advances in Surgery

Recent Advances in Surgery

Recent advances in surgery of the larynx and trachea.

Recent advances in surgery of the larynx and trachea have occurred in the general areas of diagnosis, pretreatment nutritional therapy, surgical technique, and reconstruction. In diagnosis the routine use of the flexible fiberoptic laryngoscope in the office and the use of computerized tomography have been valuable. The addition of enteral and parenteral nutrition therapy in selected patients with laryngeal cancer has been an advance. In the area of surgical technique, section of the recurrent nerve for the treatment of abductor laryngeal spastic dysphonia has proved successful. In the area of reconstruction the use of the epiglottic flap for repair of the larynx after near-total laryngectomy for glottic cancer and the use of the pectoralis major myocutaneous flap for one-stage pharyngoesophageal reconstruction have been significant advances. An increase in the number of patients with chronic lung disease has created a new interest in tracheal fenestration.

Recent Advances in Surgery of Lower Limb Deficiencies

A vast literature describing the treatment of lower limb deficiencies has accumulated in the past 20 years. Amputation and prosthetic replacement has come to be recognized as the major technique of limb-length restoration in these major lower-limb deficiencies. Experience has shown that early amputation can avoid major repetitive surgical procedures, and that disarticulation is the procedure of choice in the young child. A better understanding of the natural history of these major limb deficiencies has permitted the surgeon to develop a treatment program when the child is first seen, and to be able to recommended it to the parents with confidence.

Recent Advances in Surgery

Recent Advances in Surgery

Recent Advances in Surgery #9 ed. by Selwyn Taylor (review)

Recent Advances in Surgery #9 ed. by Selwyn Taylor (review)

Recent Advances in Surgery

This book, the ninth in a series, entitled Recent Advances in Surgery , is an attempt on the part of the editor to include subjects where there has been a complete change of approach, those in which the pattern of treatment has now emerged clearly and finally, I have included descriptions of new techniques which seem to me to have reasonably wide applications in surgery. Hence, subjects from portal hypertension to regional renal hypothermia to Systeme International d'Unites (SI) have been included. This noble effort has succeeded to the extent that the contributors are recognized as international authorities in their fields. However, with such a potpourri it is hard to imagine that it would be a particularly useful book for the average surgeon and unnecessary for the specialist. One is left with the conclusion that this edition should probably join the previous eight on the shelves of reference libraries where a

Book Review: Recent Advances in Surgery 9

Book Review: Recent Advances in Surgery 9