Rear-end accidents, as one of the common accident types, may cause serious injuries to the driver and passengers. There are mutual coupling effects among causal features of rear-end accidents, and traditional analytical methods may lead to modeling distortion due to assumption constraints. In this study, the Light Gradient Boosting Machine (LightGBM), a machine learning algorithm, is used to model the injury severity of the following vehicle driver in a rear-end crash accident on a straight road, based on the data from the China In-depth Accident Study data. The Shapley Additive Explanations (SHAP) method was used to interpret the results of the LightGBM model and to analyze the relationship between factors and driver injury severity. The results show that location familiarity, willingness to take risks, and driving time have a significant impact on the injury severity for following vehicle drivers involved in rear-end crashes. Cloudy conditions increase a driver’s risk of being involved in a fatal or injured rear-end collision. In rain, snow, hail, and foggy conditions, have a higher propensity to cause driver fatalities in the crash event. The rear-end crash of passenger cars resulted in a higher death probability of the following vehicle driver compared to sedan and truck, and female drivers are more likely to be involved in uninjured accidents compared to males. These results are informative for preventing rear-end accidents and reducing the extent of accidental injuries.