The pseudo-spin symmetry (PSS) provides an important angle to understand nuclear microscopic structure and the novel phenomena found in unstable nuclei. The relativistic Hartree–Fock (RHF) theory, that takes the important degrees of freedom associated with the π-meson and ρ-tensor (ρ-T) couplings into account, provides an appropriate description of the PSS restoration in realistic nuclei, particularly for the pseudo-spin (PS) doublets with high angular momenta (l˜). The investigations of the PSS within the RHF theory are recalled in this paper by focusing on the effects of the Fock terms. Aiming at common artificial shell closures appearing in previous relativistic mean-field calculations, the mechanism responsible for the PSS restoration of high-l˜ orbits is stressed, revealing the manifestation of nuclear in-medium effects on the PSS, and thus, providing qualitative guidance on modeling the in-medium balance between nuclear attractions and repulsions. Moreover, the essential role played by the ρ-T coupling, that contributes mainly via the Fock terms, is introduced as combined with the relations between the PSS and various nuclear phenomena, including the shell structure and the evolution, novel halo and bubble-like phenomena, and the superheavy magicity. As the consequences of the nuclear force in complicated nuclear many-body systems, the PSS itself and the mechanism therein can not only deepen our understanding of nuclear microscopic structure and relevant phenomena, but also provide special insight into the nature of the nuclear force, which can further enrich our knowledge of nuclear physics.