This paper deals with the coordinated control problem of the multiple high-speeds operating under the virtual coupling mode with special consideration of the coupled safety inter-train distance constraints and other independent constraints affecting train dynamics. Considering the inertial lag phenomenon within longitudinal dynamics, this study employs a third-order nonlinear control model to characterize train motion. To cope with the intricate running constraints explicitly, a centralized constrained model predictive (MPC) control problem is formulated for the regulation of the trains. Within the framework of sequential solving approach, a novel distributed model predictive control (DMPC) algorithm is designed based on a distributed train running information exchange mechanism. The algorithm decomposes the centralized MPC problem into a sequence of local problems, allowing for sequential computation and meeting the real-time control requirements. Notably, the algorithm mitigates solution conservatism arising from the distributed optimization mechanism by accounting for potential hypothetical control policies among a train’s topological neighbors when designing its control policy. The feasibility and effectiveness of the proposed results are rigorously confirmed through theoretical analysis and illustrated by numerical experiment results.