Previously proposed adaptive fuzzy sliding mode control (AFSMC) and adaptive fuzzy sliding mode observer (AFSMO) methods are mixed and extended for the case of affine systems in which the input gain matrix is state-dependent, non-diagonal and non-positive definite. The proposed Extended AFSMCO (E-AFSMCO) method is then applied for position control of a Stewart Manipulator (SM), whose parameters are strongly state-dependent and complex and not suitable for practical control purposes. A robust observer-based control method which can work with a simplified model of the plant, and at the same time can preserve the stability and performance of the overall complex system is of great need. In this study, the SM dynamic model is simplified by removing the dynamic effects of the legs and the neglected terms are considered as un-modeled dynamics, for which the upper bound of the uncertainty is progressively estimated using the proposed adaptation rules. The final controller is comprised of a fuzzy controller in parallel with a robust switching controller. The second Lyapunov theorem is used to prove the closed-loop asymptotic stability. The proposed E-AFSMCO method is verified numerically and experimentally, depicting the effectiveness of the method for real-time industrial applications.